Browsing by Author "pomposo, jose a."
Now showing items 1-20 of 29
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A method to estimate the size of single-chain nanoparticles under severe crowding conditions
Asenjo Sanz, Isabel; Verde Sesto, Ester; Pomposo Alonso, José Adolfo (Royal Society of Chemistry, 2022-01-05)[EN] Single-chain nanoparticles (SCNPs) result from the folding of isolated polymer chains via intramolecular interactions. Currently, there is no theory able to rationalize the astonishing conformational behaviour of SCNPs ... -
Advances in Click Chemistry for Single-Chain Nanoparticle Construction
Single-chain polymeric nanoparticles are artificial folded soft nano-objects of ultra-small size which have recently gained prominence in nanoscience and nanotechnology due to their exceptional and sometimes unique properties. ... -
Advances in Fluorescent Single-Chain Nanoparticles
Fluorophore molecules can be monitored by fluorescence spectroscopy and microscopy, which are highly useful and widely used techniques in cell biology, biochemistry, and medicine (e.g., biomarker analysis, immunoassays, ... -
Advances in Single-Chain Nanoparticles for Catalysis Applications
Enzymes are the most efficient catalysts known for working in an aqueous environment near room temperature. The folding of individual polymer chains to functional single-chain nanoparticles (SCNPs) offers many opportunities ... -
Advances in the Multi-Orthogonal Folding of Single Polymer Chains into Single-Chain Nanoparticles
Blázquez Martín, Agustín; Verde Sesto, Ester; Moreno Segurado, Angel José; Arbe Méndez, María Aranzazu; Colmenero de León, Juan ; Pomposo Alonso, José Adolfo (MDPI, 2021-01-18)The folding of certain proteins (e.g., enzymes) into perfectly defined 3D conformations via multi-orthogonal interactions is critical to their function. Concerning synthetic polymers chains, the “folding” of individual ... -
Advances in the Phototriggered Synthesis of Single-Chain Polymer Nanoparticles
Clean use of photons from light to activate chemical reactions offers many possibilities in different fields, from chemistry and biology to materials science and medicine. This review article describes the advances carried ... -
Collective Motions and Mechanical Response of a Bulk of Single-Chain Nano-Particles Synthesized by Click-Chemistry
Maiz, Jon; Verde Sesto, Ester; Asenjo Sanz, Isabel; Fouquet, Peter; Porcar, Lionel; Pomposo Alonso, José Adolfo ; Malo de Molina, Paula; Arbe Méndez, María Aranzazu; Colmenero de León, Juan (MDPI, 2020-12-25)We investigate the effect of intra-molecular cross-links on the properties of polymer bulks. To do this, we apply a combination of thermal, rheological, diffraction, and neutron spin echo experiments covering the inter-molecular ... -
Controlling the stereospecific bonding motif of Au-thiolate links
Colazzo, Luciano; Mohammed, Mohammed S. G.; Gallardo, Aurelio; Abd El-Fattah, Z. M.; Pomposo Alonso, José Adolfo ; Jelinek, Pavel; García de Oteyza Feldermann, Dimas (Royal Society of Chemistry, 2019-09-07)Over the last decades, organosulfur compounds at the interface of noble metals have proved to be extremely versatile systems for both fundamental and applied research. However, the anchoring of thiols to gold remained an ... -
Disentangling Component Dynamics in an All-Polymer Nanocomposite Based on Single-Chain Nanoparticles by Quasielastic Neutron Scattering
Maiz, Jon; Verde Sesto, Ester; Asenjo Sanz, Isabel; Mangin-Thro, Lucile; Frick, Bernhard; Pomposo Alonso, José Adolfo ; Arbe Méndez, María Aranzazu; Colmenero de León, Juan (American Chemical Society, 2022-02)[EN] We have investigated an all-polymer nanocomposite (NC) consisting of single-chain nanoparticles (SCNPs) immersed in a matrix of linear chains of their precursors (25/75% composition in weight). The SCNPs were previously ... -
Dynamic Processes and Mechanisms Involved in Relaxations of Single-Chain Nano-Particle Melts
Maiz, Jon; Verde Sesto, Ester; Asenjo Sanz, Isabel; Malo de Molina, Paula; Frick, Bernhard; Pomposo Alonso, José Adolfo ; Arbe Méndez, María Aranzazu; Colmenero de León, Juan (MDPI, 2021-07-14)We present a combined study by quasielastic neutron scattering (QENS), dielectric and mechanical spectroscopy, calorimetry and wide-angle X-ray diffraction on single-chain nano-particles (SCNPs), using the corresponding ... -
Efficient Synthesis of Single-Chain Polymer Nanoparticles via Amide Formation
Single-chain technology (SCT) allows the transformation of individual polymer chains to folded/collapsed unimolecular soft nanoparticles. In this work we contribute to the enlargement of the SCT toolbox by demonstrating ... -
Glass-Transition Dynamics of Mixtures of Linear Poly(Vinyl Methyl Ether) with Single-Chain Polymer Nanoparticles: Evidence of a New Type of Nanocomposite Materials
Robles Hernández, Beatriz; González Burgos, Marina; Pomposo Alonso, José Adolfo ; Colmenero de León, Juan ; Alegría Loinaz, Iñaki (MDPI, 2019-03-21)Single-chain polymer nanoparticles (SCNPs) obtained through chain collapse by intramolecular cross-linking are attracting increasing interest as components of all-polymer nanocomposites, among other applications. We present ... -
Gold Nanoclusters Synthesized within Single-Chain Nanoparticles as Catalytic Nanoreactors in Water
Pinacho Olaciregui, Jokin; Verde Sesto, Ester; Taton, Daniel; Pomposo Alonso, José Adolfo (MDPI, 2024-01-30)Metalloenzymes are able to catalyze complex biochemical reactions in cellular (aqueous) media with high efficiency. In recent years, a variety of metal-containing single-chain nanoparticles (SCNPs) have been synthesized ... -
Homogenization of Mutually Immiscible Polymers Using Nanoscale Effects: A Theoretical Study
Montes, Sarah; Etxeberria Lizarraga, Agustín ; Rodríguez, Javier; Pomposo Alonso, José Adolfo (Hindawi Publishing Corporation, 2008)A theoretical study to investigate homogenization of mutually immiscible polymers using nanoscale effects has been performed. Specifically, the miscibility behavior of all-polymer nanocomposites composed of linear-polystyrene ... -
Intra- vs Intermolecular Cross-Links in Poly(methyl methacrylate) Networks Containing Enamine Bonds
Sharifi, Soheil; Asenjo Sanz, Isabel; Pomposo Alonso, José Adolfo ; Alegría Loinaz, Angel María (American Chemical Society, 2022)The molecular dynamics of a copolymer composed of methyl methacrylate (MMA) and (2-acetoacetoxy)ethyl methacrylate (AEMA) monomers and the influence on it of intra-to intermolecular cross-links of AEMA units with ethylenediamine ... -
Metal-Free Polymethyl Methacrylate (PMMA) Nanoparticles by Enamine "Click" Chemistry at Room Temperature
"Click" chemistry has become an efficient avenue to unimolecular polymeric nanoparticles through the self-crosslinking of individual polymer chains containing appropriate functional groups. Herein we report the synthesis ... -
Metamorphosis of a Commodity Plastic like PVC to Efficient Catalytic Single-Chain Nanoparticles
Blázquez Martín, Agustín; Verde Sesto, Ester; Arbe Méndez, María Aranzazu; Pomposo Alonso, José Adolfo (Wiley, 2023-11)We perform the conversion of a commodity plastic of common use in pipes, window frames, medical devices, flexible hoses, etc. like polyvinyl chloride (PVC) to single-chain nanoparticles (SCNPs). SCNPs are versatile, ... -
Neat Protein Single-Chain Nanoparticles from Partially Denatured BSA
Malo de Molina, Paula; Le, Thu Phuong; Iturrospe Ibarra, Amaia; Gasser, Urs; Arbe Méndez, María Aranzazu; Colmenero de León, Juan ; Pomposo Alonso, José Adolfo (American Chemical Society, 2022)The main challenge for the preparation of protein single-chain nanoparticles (SCNPs) is the natural complexity of these macromolecules. Herein, we report the suitable conditions to produce "neat" bovine serum albumin (BSA) ... -
New synthetic routes, topologies and physical properties of single-chain nanoparticles.
Rubio Cervilla, Jon (2019-04-03)Esta tesis presenta un trabajo exhaustivo en torno a las nanopartículas poliméricas unimoleculares (SCNPs, por sus siglas en inglés). La combinación de técnicas de síntesis de polímeros de vanguardia y técnicas de ... -
Novel synthesis routes of bioinspired nanoparticles and bio-based films
Latorre Sánchez, Alejandro (2017-06-30)La nanotecnología es un campo en continuo auge dedicada al estudio de objetos comprendidos entre unos pocos nanómetros y los 100 nanómetros. Debido a la gran relevancia de este tema, una parte de esta tesis se centra en ...