BackBrowsing by Author "Goni, Felix M"
Now showing items 1-20 of 49
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A Computational Module Assembled from Different Protease Family Motifs Identifies PI PLC from Bacillus cereus as a Putative Prolyl Peptidase with a Serine Protease Scaffold
; ; ; ; ; ; ; Goñi Urcelay, Félix María
; (Public Library Science, 2013-08)
Proteolytic enzymes have evolved several mechanisms to cleave peptide bonds. These distinct types have been systematically categorized in the MEROPS database. While a BLAST search on these proteases identifies homologous ... -
A fluorogenic cyclic peptide for imaging and quantification of drug-induced apoptosis
Barth, Nicole D.; Subirós Funosas, Ramón; Mendive Tapia, Lorena; Duffin, Rodger; Shields, Mario A.; Cartwright, Jennifer A.; Troeira Henriques, Sónia; Sot, Jesús; Goñi Urcelay, Félix María; Lavilla, Rodolfo; Marwick, John A.; Vermeren, Sonja; Rossi, Adriano G.; Egeblad, Mikala; Dransfield, Ian; Vendrell, Marc (Nature, 2020-08-12)
Programmed cell death or apoptosis is a central biological process that is dysregulated in many diseases, including inflammatory conditions and cancer. The detection and quantification of apoptotic cells in vivo is hampered ... -
Accumulated Bending Energy Elicits Neutral Sphingomyelinase Activity in Human Red Blood Cells
López Jiménez, David; ; ; ; ; ; ; ; Goñi Urcelay, Félix María ; Alonso Izquierdo, Alicia (Elservier, 2012-05-02)
[EN] We propose that accumulated membrane bending energy elicits a neutral sphingomyelinase (SMase) activity in human erythrocytes. Membrane bending was achieved by osmotic or chemical processes, and SMase activity was ... -
Adenylate Cyclase Toxin promotes bacterial internalisation into non phagocytic cells
; ; ; ; González Bullón, David; Arluzea de Jauregizar, Jon Andoni ; Goñi Urcelay, Félix María ; Arechaga Martínez, Juan Miguel ; (Nature Publishing Group, 2015-09-08)
Bordetella pertussis causes whooping cough, a respiratory infectious disease that is the fifth largest cause of vaccine-preventable death in infants. Though historically considered an extracellular pathogen, this bacterium ... -
Arachidyl Amido Cholanoic Acid Improves Liver Glucose and Lipid Homeostasis in Nonalcoholic Steatohepatitis Via AMPK and mTOR Regulation
Fernández Ramos, David; Lopitz Otsoa, Fernando; De la Cruz Villar, Laura; Bilbao García, Jon; Pagano, Martina; Mosca, Laura; Bizkarguenaga, Maider; ; ; Iruarrizaga Lejarreta, Marta; Sot, Jesús; Tsvirkun, Darya; Van Liempd, Sebastiaan Martijn; Goñi Urcelay, Félix María; Alonso, Cristina; Martínez Chantar, María Luz ; ; Hayardeny, Liat; Lu, Shelly C.; Mato, José M. (Baishideng, 2020-09-14)
BACKGROUND Arachidyl amido cholanoic acid (Aramchol) is a potent downregulator of hepatic stearoyl-CoA desaturase 1 (SCD1) protein expression that reduces liver triglycerides and fibrosis in animal models of steatohepatitis. ... -
Autophagy protein LC3C binding to phospholipid and interaction with lipid membranes
; ; ; ; ; ; Montes Burgos, Lidia Ruth; ; Goñi Urcelay, Félix María ; Alonso Izquierdo, Alicia (Elsevier, 2022-05-23)
Autophagy is a process in which parts of the eukaryotic cell are selectively degraded in the lysosome. The materials to be catabolized are first surrounded by a double-membrane structure, the autophagosome. Autophagosome ... -
Biophysical properties of sphingolipid-deficient cell membranes
Gutiérrez Monasterio, Bingen (2021-09-30)
Esta tesis pretende explorar la función de los esfingolípidos en el crecimiento celular y en la composición y las propiedades físicas de las membranas. Para ello se han utilizado células que poseen una síntesis limitada ... -
Birth and Early Steps of the Organization of Biophysics in Spain
Goñi Urcelay, Félix María (MDPI, 2022-11-19)
In the 1960s, Biophysics was an unheard of scientific field in Spain, and even outside Spain, the distinction between Biophysics and Molecular Biology was not clear at the time. This paper describes briefly the developments ... -
C24:0 and C24:1 sphingolipids in cholesterol-containing, five- and six-component lipid membranes
; García Arribas, Aritz; ; Goñi Urcelay, Félix María ; Alonso Izquierdo, Alicia (Nature, 2020-08-24)
The biophysical properties of sphingolipids containing lignoceric (C24:0) or nervonic (C24:1) fatty acyl residues have been studied in multicomponent lipid bilayers containing cholesterol (Chol), by means of confocal ... -
Ceramide-enriched membrane domains in red blood cells and the mechanism of sphingomyelinase-induced hot-cold haemolysis
Montes Burgos, Lidia Ruth; López Jiménez, David ; Sot, Jesus ; Bagatolli, Luis ; ; ; ; ; Goñi Urcelay, Félix María ; Alonso Izquierdo, Alicia (American Chemical Society, 2008-10-28)
Hot-cold hemolysis is the phenomenon whereby red blood cells, preincubated at 37 °C in the presence of certain agents, undergo rapid hemolysis when transferred to 4 °C. The mechanism of this phenomenon is not understood. ... -
Cerebro, lipidómica y alzheimer: estudio de biomarcadores y neuroimagen en personas sanas.
Iriondo Juaristi, Ane (2020-07-16)
El objetivo general de esta tesis es ampliar el conocimiento sobre la fisiopatología de la EA e investigar la posible interrelación existente entre tres hechos biológicos cerebrales que podrían estar involucrados en los ... -
Changes in Membrane Organization upon Spontaneous Insertion of 2‑Hydroxylated Unsaturated Fatty Acids in the Lipid Bilayer
; Ibarguren, Maitane; ; López Jiménez, David ; ; ; Goñi Urcelay, Félix María ; Escriba, Pablo (American Chemical Society, 2014-02-03)
Recent research regarding 2-hydroxylated fatty acids (2OHFAs) showed clear evidence of their benefits in the treatment of cancer, inflammation, and neurodegenerative disorders such as Alzheimer’s disease. Monolayer ... -
CHO/LY-B Cell Growth under Limiting Sphingolipid Supply: Correlation between Lipid Composition and Biophysical Properties of Sphingolipid-Restricted Cell Membranes
Gutiérrez Monasterio, Bingen; Jiménez Rojo, Noemi; García Arribas, Aritz ; Riezman, Howard; Goñi Urcelay, Félix María ; Alonso Izquierdo, Alicia (Wiley, 2021-06)
Sphingolipids (SL) are ubiquitous in mammalian cell membranes, yet there is little data on the behavior of cells under SL- restriction conditions. LY- B cells derive from a CHO linein whichserine palmitoyl transferase ... -
Determinación estructural de virus con envuelta lipída mediante crio-microscopía electrónica.
(2020-02-10)Viruses are parasitic biological agents that in the virion state contain differentmorphologies and assembly organisations. In some virions, a lipid membrane of cellularorigin is a structural component of the infectious ... -
DNA y herencia: Problemas éticos y aplicaciones médico-legales
Goñi Urcelay, Félix María (Instituto Vasco de Criminología, 1992-12)
Exposición de los aspectos positivos y negativos de los recientes avances de la biología, con especial referencia a los aspectos médico-legales. -
Effect of ATG12–ATG5-ATG16L1 autophagy E3-like complex on the ability of LC3/GABARAP proteins to induce vesicle tethering and fusion
; ; ; ; ; ; ; ; Montes Burgos, Lidia Ruth; Goñi Urcelay, Félix María ; Alonso Izquierdo, Alicia (Springer, 2023-02)
In macroautophagy, the autophagosome (AP) engulfs portions of cytoplasm to allow their lysosomal degradation. AP formation in humans requires the concerted action of the ATG12 and LC3/GABARAP conjugation systems. The ... -
Effects of a N-Maleimide-derivatized Phosphatidylethanolamine on the Architecture and Properties of Lipid Bilayers
; ; De la Arada Echevarría, Igor; ; ; Goñi Urcelay, Félix María ; Alonso Izquierdo, Alicia ; Montes Burgos, Lidia Ruth (MDPI, 2023-11-21)
<i>N</i>-maleimide-derivatized phospholipids are often used to facilitate protein anchoring to membranes. In autophagy studies, this is applied to the covalent binding of Atg8, an autophagy protein, to a phosphatidylethanolamine ... -
Erythrocyte Membrane Nanomechanical Rigidity Is Decreased in Obese Patients
Sot, Jesús; García Arribas, Aritz; Abad García, Beatriz; Arranz, Sara; Portune, Kevin; Andrade, Fernando; Martín Nieto, Alicia; Velasco, Olaia; Arana, Eunate; Tueros, Itziar; Ferreri, Carla; Gaztambide Sáenz, María Sonia; Goñi Urcelay, Félix María ; Castaño González, Luis Antonio ; Alonso Izquierdo, Alicia (MDPI, 2022-02-08)
This work intends to describe the physical properties of red blood cell (RBC) membranes in obese adults. The hypothesis driving this research is that obesity, in addition to increasing the amount of body fat, will also ... -
Esfingolipidoak eta kolesterola, egitura lipidoak baino gehiago
Gutiérrez Monasterio, Bingen; García Arribas, Aritz ; Alonso Izquierdo, Alicia ; Goñi Urcelay, Félix María (Servicio Editorial de la Universidad del País Vasco/Euskal Herriko Unibertsitatearen Argitalpen Zerbitzua, 2019)
Sphingolipids contain in their polar heads chemical groups allowing them to establish a complex network of H-bonds through different –OH and –NH–groups with other lipids in the bilayer. In the recent years the specific ... -
Estudios del efecto de la radiación ionizante sobre la permeabilidad de membranas modelo
(2016-04-27)La membrana biológica es una barrera hidrofóbica semipermeable de naturaleza compleja, cuya estructura consiste en una doble capa de moléculas de lípidos en la cual las proteínas están insertadas. Existen diferentes modelos ...