BackBrowsing by Author "Caballero Camino, Francisco Javier"
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Design, chemical synthesis and biological evaluation of new synthetic conjugates of ursodeoxycholic acid for the inhibition of cystogenesis in experimental models of polycystic liver disease.
Caballero Camino, Francisco Javier
(2019-11-05)
Antecedentes y objetivos: Las enfermedades hepáticas poliquísticas (PLD) son un grupo heterogéneo de trastornos genéticos hereditarios caracterizados por el desarrollo progresivo de múltiples quistes biliares llenos de ... -
Inhibition of NAE-dependent protein hyper-NEDDylation in cystic cholangiocytes halts cystogenesis in experimental models of polycystic liver disease
; ; Caballero Camino, Francisco Javier; ; Rodrigues, Pedro M.; Perugorria Montiel, María Jesús; ; ; Martínez Chantar, María Luz ; ; Bujanda Fernández de Pierola, Luis ; Drenth, Joost P. H.; Bañales Asurmendi, Jesús María (Sage, 2021-09)
Background Polycystic liver diseases (PLDs) are genetic inherited disorders characterized by the progressive growth of numerous intrahepatic biliary cysts, which are the main cause of morbidity. Previous studies revealed ... -
Synthetic Conjugates of Ursodeoxycholic Acid Inhibit Cystogenesis in Experimental Models of Polycystic Liver Disease
Caballero Camino, Francisco Javier; Rivilla de la Cruz, Iván ; Herráez Aguilar, Elisa; Briz Sánchez, Oscar; Santos Laso, Álvaro; ; ; Rodrigues, Pedro M.; Muñoz Garrido, Patricia; Jin, Sujeong; Peixoto, Estanislao; Richard, Seth; Gradilone, Sergio A.; Perugorria Montiel, María Jesús; Esteller, Manel; Bujanda Fernández de Pierola, Luis ; Marin, José J. G.; Bañales Asurmendi, Jesús María ; Cossío Mora, Fernando Pedro (Wiley, 2020-09-22)
Background and Aims Polycystic liver diseases (PLDs) are genetic disorders characterized by progressive development of symptomatic biliary cysts. Current surgical and pharmacological approaches are ineffective, and liver ... -
Targeting NAE1-mediated protein hyper-NEDDylation halts cholangiocarcinogenesis and impacts on tumor-stroma crosstalk in experimental models.
; ; ; ; Cadamuro, Massimiliano; ; ; Caballero Camino, Francisco Javier ; ; ; ; ; Martínez Chantar, María Luz ; Ávila, Matías A. ; ; CALVISI, Diego Francesco ; ; ; Castro, Rui ; ; ; Bujanda Fernández de Pierola, Luis ; ; Perugorria, Maria Jesus ; Bañales Asurmendi, Jesús María (Elsevier, 2022-07)
[EN] BACKGROUND & AIMS: Cholangiocarcinoma (CCA) comprises a heterogeneous group of malignant tumors associated with dismal prognosis. Alterations in post-translational modifications (PTMs), including NEDDylation, result ... -
Targeting UBC9-Mediated Protein Hyper-SUMOylation in Cystic Cholangiocytes Halts Polycystic Liver Disease in Experimental Models
; ; Caballero Camino, Francisco Javier; ; ; ; ; ; Martínez Chantar, María Luz ; ; ; ; ; Bujanda Fernández de Pierola, Luis ; ; Bañales Asurmendi, Jesús María (Elsevier, 2021-02)
BACKGROUND & AIMS: Polycystic liver diseases (PLDs) are genetic disorders characterized by progressive development of multiple fluid-filled biliary cysts. Most PLD-causative genes participate in protein biogenesis and/or ...