Browsing by Author "BADIOLA, IKER"
Now showing items 1-20 of 20
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9. motako subtilisina/kexina proproteina konbertasaren (PCSK9) inhibizioaren eragina koloneko minbizi-zelula ametan (MZA)
Gómez-Coronado Martín, Rafael (2021-12-22)[EUS] Minbizi-zelula amak (MZA) minbizi askoren erresistentziaren eta berragerpenen atzean daudela uste da, eta beraz, horiek aztertzea ezinbestekoa da etorkizunean tratamendu eraginkorrak sortzeko. Munduan minbiziak ... -
Altered expression of fibroblast activation protein-α (FAP) in colorectal adenoma-carcinoma sequence and in lymph node and liver metastases
Solano Iturri, Jon Danel; Beitia Loinaz, Maider; Errarte Yarza, Peio; Calvete Candenas, Julio; Etxezarraga Zuluaga, María Carmen; Loizate Totoricagüena, Alberto; Echevarría Orella, Enrique; Badiola Echaburu, Iker
; Larrinaga Embeita, Gorka
(Impact Journals, 2020-06-15)
Colorectal cancer (CRC) is a major health problem in elderly people because of its high incidence and high mortality rate. Despite early screening programs, more than half of CRC patients are diagnosed at advanced stages. ... -
An Integrative Omics Approach Reveals Involvement of BRCA1 in Hepatic Metastatic Progression of Colorectal Cancer
Gerovska, Daniela; Larrinaga Embeita, Gorka; Solano Iturri, Jon Danel; Márquez Clavijo, Joana
; García Gallastegui, Patricia
; Khatib, Abdel Majid; Poschmann, Gereon; Stühler, Kai; Armesto, María; Lawrie, Charles; Badiola Echaburu, Iker
; Araúzo Bravo, Marcos J. (MDPI, 2020-08-22)
(1) Background & Aims: The roles of different cells in the tumor microenvironment (TME) are critical to the metastatic process. The phenotypic transformation of the liver cells is one of the most important stages of the ... -
Análisis de la proteína de activación de fibroblastos a (FAP) en el carcinoma colorrectal
Solano Iturri, Jon Danel (2019-11-30)Los fibroblastos asociados al cáncer son uno de los componentes mayoritarios del microambiente tumoral. La expresión de uno de sus marcadores, la Proteína de Activación de Fibroblastos ¿ (FAP) recientemente se ha vinculado ... -
Association among University Students’ Motivation, Resilience, Perceived Competence, and Classroom Climate from the Perspective of Self-Determination Theory
Sánchez de Miguel, Manuel Norberto; Orkaizagirre Gomara, Aintzane; Izagirre Otaegi, Andrea; Badiola Echaburu, Iker
; Ortiz de Elguea Díaz, Francisco Javier
; Gómez Gastiasoro, Ainara; Ferriz Valero, Alberto; Goudas, Marios (MDPI, 2023-01-30)
Self-determination theory (SDT) suggests that motivation can interact with resilience and perceived competence. The climate-related characteristics of the classroom can influence student motivation. This study aimed to ... -
Development, Application and Evaluation of an Active Learning Methodology for Health Science Students, Oriented towards Equity and Cultural Diversity in the Treatment and Care of Geriatric Patients
Sánchez de Miguel, Manuel Norberto; Orkaizagirre Gomara, Aintzane; Izagirre Otaegi, Andrea; Ortiz de Elguea Díaz, Francisco Javier
; Badiola Echaburu, Iker
; Gómez Gastiasoro, Ainara (MDPI, 2022-11-06)
The increased aging of populations and rises in immigration have prompted the design of new methodologies and instruments for fostering the invisible care of geriatric patients among health science students in accordance ... -
Estudio comparativo entre tumor primario y metastásico de la trimetilación de la Histona H3 en el modelo in vivo de metástasis hepática de cáncer colorrectal murino.
Schaub Clerigué, Ariane (2014-06-24)Los mecanismos epigenéticos, entre los que está implicada la modificación covalente de histonas, son esenciales para el mantenimiento estable de la actividad génica en las células. Estos mecanismos también están ... -
Furin Prodomain ppFurin Enhances Ca2+ Entry Through Orai and TRPC6 Channels’ Activation in Breast Cancer Cells
López, Jose J.; Siegfried, Geraldine; Cantonero, Carlos; Soulet, Fabienne; Descarpentrie, Jean; Smani, Tarik; Badiola Echaburu, Iker; Pernot, Simon; Evrard, Serge; Rosado, Juan A.; Khatib, Abdel-Majid (MDPI, 2021-04-01)
The intracellular calcium concentration ([Ca2+]i) modulation plays a key role in the regulation of cellular growth and survival in normal cells and failure of [Ca2+]i homeostasis is involved in tumor initiation and ... -
GeromiRs Are Downregulated in the Tumor Microenvironment during Colon Cancer Colonization of the Liver in a Murine Metastasis Model
Gerovska, Daniela; García Gallastegui, Patricia; Crende Arruabarrena, Olatz
; Márquez Clavijo, Joana
; Larrinaga Embeita, Gorka
; Unzurrunzaga, Maite; Araúzo Bravo, Marcos J.; Badiola Echaburu, Iker
(MDPI, 2021-05-01)
Cancer is a phenomenon broadly related to ageing in various ways such as cell cycle deregulation, metabolic defects or telomerases dysfunction as principal processes. Although the tumor cell is the main actor in cancer ... -
Giza kolon eta ondesteko minbizidun zelulalerroetatik eratorritako ama-zeluletan PCSK9 proteinaren inhibizioak duen eragina
Urdangarin Ollo, Maddi (2021-12-03)[EUS] Minbiziak 2020. urtean 10 milioi heriotza inguru eragin zituen, horietatik guztietatik 935.000 zegozkion kolon eta ondesteko minbiziari. Oro har, kirurgia, kimioterapia edota erradioterapia gisako sendabideen bidez ... -
Is There Such a Thing as a Genuine Cancer Stem Cell Marker? Perspectives from the Gut, the Brain and the Dental Pulp
Crende Arruabarrena, Olatz; García Gallastegui, Patricia
; Luzuriaga González, Jon
; Badiola Echaburu, Iker
; De la Hoz Torres, Carmen; Unda Rodríguez, Fernando José
; Ibarretxe Bilbao, Gaskon
; Pineda Martí, José Ramón
(MDPI, 2020-11-27)
The conversion of healthy stem cells into cancer stem cells (CSCs) is believed to underlie tumor relapse after surgical removal and fuel tumor growth and invasiveness. CSCs often arise from the malignant transformation of ... -
PCSK9 proteinaren adierazpena minbizi ama zeluletan giza pazienteen kolon eta ondesteko minbizi biopsietan
Fontal Moa, Naroa (2021-12-03)[EUS] Kolon eta ondesteko minbiziak intzidentzia handia du mundu mailan, hirugarren minbizi ohikoena izanik. Gainera, minbizi mota honek tumore errepikariak eta metastasiak sortzeko joera du, portzentaje handi baten. Gero ... -
Proteina konbertasen adierazpena minbizi-zelula parental eta minbizi-zelula ametan (CSC)
Oiartzabal Narbarte, Irati (2018-04-18)[EUS] Minbizia hilkortasun oso handiko gaitza da, 2015. urtean 8,8 milioi hildako eragin zituen. Nahiz eta tratamendu bortitz eta luzeak aplikatu, askotan denbora baten ostean gaixotasunaren errekurrentzia gertatzen da, ... -
Role of Furin in Colon Cancer Stem Cells Malignant Phenotype and Expression of LGR5 and NANOG in KRAS and BRAF-Mutated Colon Tumors
Descarpentrie, Jean; Araúzo Bravo, Marcos J.; He, Zongsheng; François, Alexia; González, Álvaro; García Gallastegui, Patricia; Badiola Echaburu, Iker
; Evrard, Serge; Pernot, Simon; Creemers, John W. M.; Khatib, Abdel-Majid (MDPI, 2022-02-25)
Proprotein convertases or PCs are known to regulate the malignant phenotype of colon cancer cells by different mechanisms, but their effects on cancer stem cells (CSCs) have been less widely investigated. Here, we report ... -
Role of VEGFC C-terminal fragment in colorectal cancer with metastatic capacity.
En el siglo XXI, el cáncer se ha convertido en la segunda causa de muerte en todo el mundo. Esta enfermedad es el resultado de un conjunto de mutaciones, provocando que las células crezcan, se dividan y se propaguen sin ... -
shinyCurves, a shiny web application to analyse multisource qPCR amplification data: a COVID‑19 case study
Olaechea Lázaro, Sonia; García Santisteban, Iraia; Pineda Martí, José Ramón
; Badiola Echaburu, Iker
; Alonso Alegre, Santos
; Bilbao Catalá, José Ramón
; Fernández Jiménez, Nora
(BMC, 2021-10-03)
[EN]Background Quantitative, reverse transcription PCR (qRT-PCR) is currently the gold-standard for SARS-CoV-2 detection and it is also used for detection of other virus. Manual data analysis of a small number of qRT-PCR ... -
Silencing of Sinusoidal DDR1 Reduces Murine Liver Metastasis by Colon Carcinoma
Romayor Arredondo, Irene; Badiola Echaburu, Iker
; Benedicto García, Aitor; Márquez Clavijo, Joana
; Herrero Alonso, Alba; Arteta Ruiz, Beatriz
; Olaso Montero, Elvira (Nature, 2020-10-27)
Liver metastasis depends on the collagenous microenvironment generated by hepatic sinusoidal cells (SCs). DDR1 is an atypical collagen receptor linked to tumor progression, but whether SCs express DDR1 and its implication ... -
Stem and Cancer Stem Cell Identities, Cellular Markers, Niche Environment and Response to Treatments to Unravel New Therapeutic Targets
Adult stem cells are a partially quiescent cell population responsible for natural cell renewal and are found in many different regions of the body, including the brain, teeth, bones, muscles, skin, and diverse epithelia, ... -
Testicular Germ Cell Tumours and Proprotein Convertases
Velado Egusquiza, Aitziber; Gómez Santos, Laura; Badiola Echaburu, Iker
; Sáez Crespo, Francisco José
; Alonso Arana, Edurne
(MDPI, 2022-03-23)
Testicular Germ Cell Tumours (TGCT) are widely considered a “curable cancer” due to their exceptionally high survival rate, even if it is reduced by many years after the diagnosis due to metastases and relapses. The most ... -
What Are the Roles of Proprotein Convertases in the Immune Escape of Tumors?
Mehranzadeh, Elham; Crende Arruabarrena, Olatz; Badiola Echaburu, Iker
; García Gallastegui, Patricia
(MDPI, 2022-12-19)
Protein convertases (PCs) play a significant role in post-translational procedures by transforming inactive precursor proteins into their active forms. The role of PCs is crucial for cellular homeostasis because they are ...