BackExaminar por departamento (eus.) "Kimika organikoa I"
Now showing items 21-40 of 209
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Antileishmanial Effect of 1,5- and 1,8-Substituted Fused Naphthyridines
; ; Palacios Gambra, Francisco Javier
; ; ; ; ; Alonso Pérez, Concepción Estibaliz ; (MDPI, 2023-12-22)
In the absence of a vaccine, there is a need to find new drugs for the treatment of neglected tropical diseases, such as leishmaniasis, that can overcome the many drawbacks of those currently used. These disadvantages ... -
Antitumor magnetic hyperthermia induced by RGD-functionalized Fe3O4 nanoparticles, in an experimental model of colorectal liver metastases
Arriortua, Oihane; ; Herrero de la Parte, Borja ; ; ; Plazaola Muguruza, Fernando ; ; Aizpurua Iparraguirre, Jesús María ; ; ; ; ; ; (Beilstein-Institut, 2016-10-28)
This work reports important advances in the study of magnetic nanoparticles (MNPs) related to their application in different research fields such as magnetic hyperthermia. Nanotherapy based on targeted nanoparticles could ... -
Application of 1,3-Dipolar Reactions between Azomethine Ylides and Alkenes to the Synthesis of Catalysts and Biologically Active Compounds
; Arrieta Ayestaran, Ana Jesús; Cossío Mora, Fernando Pedro (Wiley, 2018-11-25)
The (3+2) cycloaddition between azomethine ylides and alkenes is an efficient, convergent and stereocontrolled method for the synthesis of unnatural pyrrolidine and proline scaffolds. In this review, the application of ... -
Aromaticity: Quo Vadis
; ; ; ; ; ; ; ; Cossío Mora, Fernando Pedro; ; ; ; (Royal Society of Chemistry, 2023)
Aromaticity is one of the most deeply rooted concepts in chemistry. But why, if two-thirds of existing compounds can be classified as aromatic, is there no consensus on what aromaticity is? s−, p−, d−, spherical, Möbius, ... -
Asymmetric a-functionalization of cyclid ketones promoted by bronsted base/H-bond catalysts.
(2019-11-18)En esta tesis doctoral se han desarrollado nuevas metodologías para la -funcionalización regio- y estereoselectiva de cetonas cíclicas. Para ello se han empleado catalizadores con carácter bifuncional base de Brønsted/dador ... -
Asymmetric a-functionatlization of barbituric acids via bronsted base catalysis.
(2019-01-18)El objetivo de esta tesis ha sido lograr la ¿-desimetrización de amidas por medio de la organocatálisis.Este estudio ha sido enfocado a dos subconjuntos de amidas: derivados del ácido barbitúrico y ¿-iminoamidas, debido a ... -
Asymmetric catalytic approach to a-functionalized amides.
(2020-02-28)En la presente Tesis Doctoral, se han desarrollado dos nuevos pronucleófilos para reacciones catalíticas promovidas por bases de Brønsted (BB) quirales bifuncionales.Por un lado se ha demostrado la utilidad de las ... -
Asymmetric Mannich reactions of (S)-N-tert-butylsulfinyl-3,3,3-trifluoroacetaldimines with yne nucleophiles
Li, Ziyi; Wang, Li; Huang, Yunqi; Mei, Haibo; Konno, Hiroyuki; Moriwaki, Hiroki; Soloshonok, Vadym Anatolievch; Han, Jianlin (Beilstein-Institut, 2020-10-29)
In the present work, arylethynes were studied as new C-nucleophiles in the asymmetric Mannich addition reactions with (S)-N-tert-butylsulfinyl-3,3,3-trifluoroacetaldimine. The reactions were conducted under operationally ... -
Asymmetric Michael Addition in Synthesis of β-Substituted GABA Derivatives
Han, Jianlin; ; Fustero, Santos ; ; Soloshonok, Vadym Anatolievch ; Sorochinsky, Alexander (MDPI, 2022)
γ-Aminobutyric acid (GABA) represents one of the most prolific structural units widely used in the design of modern pharmaceuticals. For example, β-substituted GABA derivatives are found in numerous neurological drugs, ... -
Asymmetric Synthesis of N-Fmoc-(S)-7-aza-tryptophan via Alkylation of Chiral Nucleophilic Glycine Equivalent
Zou, Yupiao; Takeda, Ryosuke; Han, Jianlin; Konno, Hiroyuki; Moriwaki, Hiroki; Abe, Hidenori; Izawa, Kunisuke; Soloshonok, Vadym Anatolievch (Wiley, 2021-06-07)
Ni(II)-complexes, derived from glycine Schiff bases with chiral tridentate ligands, have been used as powerful tools for the synthesis of structurally diverse tailor-made amino acids. In this manuscript, asymmetric alkylation ... -
Asymmetric Synthesis of Tailor-Made Amino Acids Using Chiral Ni(II) Complexes of Schiff Bases. An Update of the Recent Literature
Zou, Yupiao; Han, Jianlin; Saghyan, Ashot S.; Mkrtchyan, Anna F.; Konno, Hiroyuki; Moriwaki, Hiroki; Izawa, Kunisuke; Soloshonok, Vadym Anatolievch (MDPI, 2020-06-12)
Tailor-made amino acids are indispensable structural components of modern medicinal chemistry and drug design. Consequently, stereo-controlled preparation of amino acids is the area of high research activity. Over last ... -
Asymmetric Synthesis of Tetrasubstituted α-Aminophosphonic Acid Derivatives
Maestro Burzaco, Aitor; ; López Francés, Adrián; Martínez de Marigorta Izaga, Edorta ; Palacios Gambra, Francisco Javier ; Vicario Hernando, Javier (MDPI, 2021-05-27)
Due to their structural similarity with natural α-amino acids, α-aminophosphonic acid derivatives are known biologically active molecules. In view of the relevance of tetrasubstituted carbons in nature and medicine and the ... -
Ba+2 ion trapping using organic submonolayer for ultra-low background neutrinoless double beta detector
; Cossío Mora, Fernando Pedro; (Nature, 2022-12)
If neutrinos are their own antiparticles the otherwise-forbidden nuclear reaction known as neutrinoless double beta decay can occur. The very long lifetime expected for these exceptional events makes its detection a daunting ... -
Beta-Hydroxyimino Phosphorus Derivatives. An Efficient Tool in Organic Synthesis
Santos Ruiz, Jesús Manuel de los; Vicario Hernando, Javier; Alonso Pérez, Concepción Estibaliz ; Palacios Gambra, Francisco Javier (Bentham Science Publishers, 2011)
[EN] The purpose of this review article is to illustrate synthetic aspects of functionalized phosphorus derivatives containing an oximo moiety at the beta-position. First section will be focused on the synthesis of phosphine ... -
Bicolour fluorescent molecular sensor for cations: design and experimental validation
; Rivilla de la Cruz, Iván; ; ; Cossío Mora, Fernando Pedro (Royal Society of Chemistry, 2021-07-02)
Molecular entities whose fluorescence spectra are different when they bind metal cations are termed bicolour fluorescent molecular sensors. The basic design criteria of this kind of compound are presented and the different ... -
Biological Evaluation of Both Enantiomers of Fluoro-Thalidomide Using Human Myeloma Cell Line H929 and Others
Tokunaga, Etsuko; Akiyama, Hidehiko; Soloshonok, Vadym Anatolievch; Inoue, Yuki; Hara, Hideaki; Shibata, Norio (Public Library Science, 2017-08-01)
Over the last few years, thalidomide has become one of the most important anti-tumour drugs for the treatment of relapsed-refractory multiple myeloma. However, besides its undesirable teratogenic side effect, its configurational ... -
Boosting background suppression in the NEXT experiment through Richardson-Lucy deconvolution
The NEXT collaboration; Almazán, H.; Aparicio Gil, Borja; Aranburu Leiva, Ane Izaskun; Benlloch-Rodríguez, J.M.; Cossío Mora, Fernando Pedro; Ferrario, P.; Generowicz, J.; Gómez Cadenas, Juan J.; Herrero, P.; Martínez-Vara, M.; Monrabal, Francesc; Oblak, E.; Odriozola Gimeno, Mikel; Ripoll, L.; Rivilla de la Cruz, Iván ; Rogero Blanco, Celia; Romeo, B.; Romo-Luque, C.; Santos, F.P.; Dos Santos, J.M.F.; Sorel, M.; Stanford, C.; Teixeira, J.M.R.; Thapa, P.; Toledo, J.F.; Torrent, J.; Usón, A.; Veloso, J.F.C.A.; Vuong, T.T.; Webb, R.; White, J.T.; Woodruff, K.; Yahlali, N. (Springer, 2021-07-21)
Next-generation neutrinoless double beta decay experiments aim for half-life sensitivities of similar to 10(27) yr, requiring suppressing backgrounds to < 1 count/tonne/yr. For this, any extra background rejection handle, ... -
Bronsted base catalysed asymmetric C-C Bond-Forming reactions with unsaturated ketones.
(2019-12-13)En esta tesis doctoral se han desarrollado nuevas metodologías para la funcionalización organocatalítica asimétrica de cetonas insaturadas empleando catalizadores bifuncionales de tipo Base de Brønsted/dador de enlace de ... -
Brønsted Base Catalyzed One-Pot Synthesis od Stereodefined Six-Member Carbocycles Featuring Transient Trienolates and a Key Intramolecular 1,6-Addition
(Wiley-VCH, 2019-07-31)Acatalyst-driven one-pot reaction sequence is developed for the enantio- and diastereoselective synthesis of tetrasubstituted cyclohexenes from simple unsaturated ketones or thioesters.The method involves atertiary ... -
Brønsted Base-Catalyzed Enantioselective α-Functionalization of Carbonyl Compounds Involving π-Extended Enolates
(Wiley, 2023-11)Chiral Brønsted base (BB) catalyzed asymmetric transformations constitute an important tool for synthesis. A meaningful fraction of these transformations proceeds through transiently generated enolate intermediates, which ...