Examinar por departamento (cas.) "Química orgánica II"
Now showing items 41-60 of 99
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Kinetic Resolution of Secondary Allyl Boronates and Their Application in the Synthesis of Homoallylic Amines
(Wiley-VCH, 2018-09-02)Highly enantioenriched, chromatographically-stable secondary allyl boronates featuring a 1,1,2,2-tetraethyl-1,2-ethanediol fragment (Epin) were obtained by kinetic resolution of their racemic mixtures. The Epin group at ... -
Lithium and Palladium mediated cyclization reactions towards the stereocontrolled synthesis of (hetero)benzo-fused indolizidines
(2016-03-18)The research work described in this thesis is focused on the use of lithium and palladium mediated cyclization reactions for the stereocontrolled synthesis of (hetero)benzo-fused indolizidines through carbon-carbon bond ... -
MCDCalc: Markov Chain Molecular Descriptors Calculator for Medicinal Chemistry
(Bentham Science, 2020)Cheminformatics models are able to predict different outputs (activity, property, chemical reactivity) in single molecules or complex molecular systems (catalyzed organic synthesis, metabolic reactions, nanoparticles, ... -
Mechanistic Insights in the Mode of Action of Bifunctional Pyrrolidine-Squaramide-derived Organocatalysts
(Wiley-VCH, 2016)The modes of catalytic action of three squaramide-derived bifunctional organocatalysts have been investigated using DFT methods. The [5+2] cycloaddition between oxidopyrilium ylides and enals has been used as model ... -
Metal-Organic Frameworks and Zeolite Materials As Active Fillers for Lithium-Ion Battery Solid Polymer Electrolytes
(Royal Society Of Chemistry, 2021-06-21)The efforts to decarbonize the economies, with particular focus on renewable energies, must be accompanied by the development of more efficient and environmentally friendlier energy storage systems. In this context, all ... -
Michael initiated organocatalytic cascade reactions
(2016-07-20)The methodologies based on Michael initiated cascade reactions represent avery useful synthetic strategy for the formation of complex compounds, startingfrom simple substrates and using straightforward procedures. In this ... -
Molecular docking, SAR analysis and biophysical approaches in the study of the antibacterial activity of ceramides isolated from Cissus incisa
(Elsevier, 2021-02-18)The developing of antibacterial resistance is becoming in crisis. In this sense, natural products play a fundamental role in the discovery of antibacterial agents with diverse mechanisms of action. Phytochemical investigation ... -
Molecular Recognition in C-Type Lectins: The Cases of DC- SIGN, Langerin, MGL, and L-Sectin
(2020-11-02)Carbohydrates play a pivotal role in intercellular communication processes. In particular, glycan antigens are key for sustaining homeostasis, helping leukocytes to distinguish damaged tissues and invading pathogens from ... -
Mono and Di-Fucosylated Glycans of the Parasitic Worm S. Mansoniare Recognized Differently by the Innate Immune Receptor DC-SIGN
(Wiley, 2020-12-01)The parasitic worm,Schistosoma mansoni, expresses unusual fucosylated glycans in a stage-dependent manner that can be recognized by the human innate immune receptor DC-SIGN, thereby shaping host immune responses. We have ... -
Nanoemulsions as drug carriers: preclinical evaluation of pulmonary delivered drug-loaded nanocapsules
(2020-10-30)En esta tesis doctoral, se ha utilizado la administración pulmonar y las técnicas de imagen molecular in vivo con el objetivo final de explorar la idoneidad de polímeros y NPs poliméricas basadas en dextrano para estabilizar ... -
Naphthyl-Containing Organophosphonate Derivatives of Keggin-Type Polyoxotungstates
(MDPI, 2016-06)New organophosphonate derivatives of monovacant Keggin-type polyoxotungstates that contain naphthyl groups have been synthesized and characterized in both solid state and solution. Single-crystal structural analysis shows ... -
Net-Net Auto Machine Learning (AutoML) Prediction of Complex Ecosystems
(Nature Publishing, 2018-08-17)Biological Ecosystem Networks (BENs) are webs of biological species (nodes) establishing trophic relationships (links). Experimental confirmation of all possible links is difficult and generates a huge volume of information. ... -
Net-Net AutoML Selection of Artificial Neural Network Topology for Brain Connectome Prediction
(MDPI, 2020-02-14)Brain Connectome Networks (BCNs) are defined by brain cortex regions (nodes) interacting with others by electrophysiological co-activation (edges). The experimental prediction of new interactions in BCNs represents a ... -
NMR and molecular recognition of compounds related to the immune system.
(2019-03-25)Glycans are among the most varied and complex molecules in biological systems. The glycosylation process is the most complex and widespread modification of proteins and lipids, with an unsurpassed capacity to generate a ... -
NMR studies of the interactions of glycan antigens with monoclonal antibodies.
(2020-06-29)Carbohydrates are one of the most variable and complex molecules of biological systems. They are usually located at the cell membrane, mainly as glycoconjugates, glycoproteins or glycolipids and play an important role in ... -
Novel asymmetric transformations under covalent organocatalysis
(2018-10-26)La aminocatálisis se ha convertido en un área de gran interés especialmente para el desarrollo de reacciones químicas estereocontroladas. Esta metodología implica la condensación de aminas primarias o secundarias quirales ... -
Novel carboxylate-based glycolipids: TLR4 antagonism, MD-2 binding and self-assembly properties
(Nature Publishing, 2019-01-29)New monosaccharide-based lipid A analogues were rationally designed through MD-2 docking studies. A panel of compounds with two carboxylate groups as phosphates bioisosteres, was synthesized with the same glucosamine-bis-succinyl ... -
Novel Dextran-Supported Biological Probes Decorated with Disaccharide Entities for Investigating the Carbohydrate-Protein Interactions of Gal-3.
(Wiley, 2018-11-30)The quest for novel natural-like biomolecular probes that can be used to gain information on biological recognition events is of topical interest to several scientific areas. In particular, the recognition of carbohydrates ... -
Novel Stereoselective Transformations under Lewis Base Catalysis
(2020-07-17)Dada la necesidad de las empresas farmacéuticas de comercializar compuestos enantioméricamente puros, la síntesis de moléculas enantiopuras ha atraído mucho interés en los últimos años. La síntesis asimétrica y en concreto, ... -
Novel strategies for the preparation of 13N-labelled compounds: Synthesis of 13N-labelled Aromatic azides, triazoles and tetrazoles
(2017-06-01)La Tomografía por Emisión de Positrones (PET) es una técnica de imagen molecular que permite conocer, de manera mínimamente invasiva y prácticamente a tiempo real, la distribución espacio-temporal de un radiotrazador marcado ...