Examinar por departamento (cas.) "Química orgánica II"
Now showing items 61-80 of 99
-
Una nueva aproximación a la síntesis de heterociclos pirrolofusionados basada en la reacción de amidación de alquinos asistida por el reactivo de yodo hipervalente PIFA
(2014-02-05)En la presente memoria se describe el trabajo de investigación llevado a cabo en relación al desarrollo de nuevas aplicaciones sintéticas de la reacción de heterociclación de alquinos funcionalizados mediante el empleo del ... -
Organocatalytic and enantioselective transannular reactions: novel strategies for the asymmetric synthesis of polycyclic structures.
(2019-06-25)Las reacciones transanulares son procesos con un gran potencial sintético ya que permiten acceder a estructuras policíclicas de forma sencilla y con un alto grado de economía de átomos. Por definición, una reacción ... -
Organocatalytic approaches to the asymmetric synthesis of N-Heterocycles: from Bronsted acid catalysis to vinylogous iminium ion activation
(2017-06-16)El presente trabajo de investigación se ha centrado en el uso de diferentes métodos de activación organocatalítica para la síntesis de compuestos orgánicos quirales de interés.Por un lado, se ha estudiado el empleo de ... -
Organocatalytic Transannular Approach to Stereodefined Bicyclo[3.1.0]hexanes
(American Chemical Society, 2018-03-12)A diastereodivergent approach to highly substituted bicyclo[3.1.0]hexanes has been developed through a transannular alkylation reaction that builds up the bicyclic core employing asymmetric organocatalysis as the tool for ... -
Organocatalytically Generated Donor − Acceptor Cyclopropanes in Domino Reactions. One-Step Enantioselective Synthesis of Pyrrolo[1,2 ‑ a ]quinolines
(American Chemical Society, 2016-03-18)An easy and straightforward procedure has been developed for the synthesis of highly enantioenriched pyrrolo-[1,2-a]quinolines through a one-pot process that comprises a domino cyclopropane ring opening/aza-Michael/aldol ... -
Palladium(II)-catalyzed Intramolecular C-H Alkenylation for the Synthesis of Chromanes
(American Chemical Society, 2019-01-14)The intramolecular Pd(II)-catalyzed alkenylation of aryl homoallyl ethers constitutes a mild, versatile, and efficient procedure for the synthesis of highly and diversely substituted chromanes, and 2H-chromenes. The use ... -
Palladium-Catalyzed Dehydrogenative Coupling: An Efficient Synthetic Strategy for the Construction of the Quinoline Core
(MDPI, 2017-09)Palladium-catalyzed dehydrogenative coupling is an efficient synthetic strategy for the construction of quinoline scaffolds, a privileged structure and prevalent motif in many natural and biologically active products, in ... -
Pd(II)-Catalyzed C-H Acylation of (Hetero)arenes. Recent Advances
(MDPI, 2020-07-16)Di(hetero)aryl ketones are important motifs present in natural products, pharmaceuticals or agrochemicals. In recent years, Pd(II)-catalyzed acylation of (hetero)arenes in the presence of an oxidant has emerged as a catalytic ... -
Perturbation Theory Model of Reactivity and Enantioselectivity of Palladium-catalyzed Heck-Heck cascade reactions
(Royal Society of Chemistry, 2016-04-13)Enantioselective intramolecular Heck-Heck cascade reactions have emerged as an excellent tool for the construction of polycyclic frameworks, such as Lycorane alkaloids, Xestoquinone and analogues. However, it is particularly ... -
Perturbation-Theory and Machine Learning (PTML). Model for High-Throughput Screening of Parham Reactions: Experimental and Theoretical Studies
(American Chemical Society, 2018-06-13)Machine Learning (ML) algorithms are gaining importance in the processing of chemical information and modelling of chemical reactivity problems. In this work, we have developed a PTML model combining Perturbation-Theory ... -
Phenolic Activation in Chiral Brønsted Acid-Catalyzed Intramolecular α‑Amidoalkylation Reactions for the Synthesis of Fused Isoquinolines
(ACS, 2017-06-16)An organolithium addition−intramolecular α- amidoalkylation sequence on N-phenethylimides has been developed for the synthesis of fused tetrahydroisoquinoline systems using 1,1′-bi-2-naphthol (binol)-derived Brønsted acids. ... -
Phosphine oxides as privileged ligands for Palladium-catalyzed a-arylation and heteroannulation reactions in water
(2018-04-13)Este trabajo de investigación se centra en el estudio del potencial catalítico de óxidos de fosfina y fuentes de paladio en diferentes transformaciones sintéticas llevadas a cabo en agua. Así, se han sintetizado 1,2-diaril- ... -
Pincer complexes as advantageous palladium sources for synthetic transformations
(2015-12-03)El trabajo de investigación que se recoge en la presente memoria se ha centrado en el desarrollo de nuevos catalizadores de paladio tipo pincer y en el estudio catalítico de los mismos en una amplia variedad de transformaciones ... -
Poly(l-lactide)-Based Anti-Inflammatory Responsive Surfaces for Surgical Implants
(MDPI, 2020-12-24)In the last few decades, surgical implants have been widely used to restore the function of damaged bones or joints. However, it is essential to receive antibiotic or anti-inflammatory treatment to circumvent significant ... -
Polycarbazole and Its Derivatives: Synthesis and Applications. A Review of the Last 10 Years
(MDPI, 2020-09-28)Polycarbazole and its derivatives have been extensively used for the last three decades, although the interest in these materials briefly decreased. However, the increasing demand for conductive polymers for several ... -
Prediction of Antimalarial Drug-Decorated Nanoparticle Delivery Systems with Random Forest Models
(MDPI, 2020-07-30)Drug-decorated nanoparticles (DDNPs) have important medical applications. The current work combined Perturbation Theory with Machine Learning and Information Fusion (PTMLIF). Thus, PTMLIF models were proposed to predict ... -
Prediction of breast cancer proteins involved in immunotherapy, metastasis, and RNA-binding using molecular descriptors and artificial neural networks
(Springer Nature, 2020-05-22)[EN] Breast cancer (BC) is a heterogeneous disease where genomic alterations, protein expression deregulation, signaling pathway alterations, hormone disruption, ethnicity and environmental determinants are involved. Due ... -
Prediction of Multi-Target Networks of Neuroprotective Compounds with Entropy Indices and Synthesis, Assay, and Theoretical Study of New Asymmetric 1,2-Rasagiline Carbamates
(MDPI, 2014-09)In a multi-target complex network, the links (L-ij) represent the interactions between the drug (d(i)) and the target (t(j)), characterized by different experimental measures (K-i, K-m, IC50, etc.) obtained in pharmacological ... -
Racemic hemiacetals as oxygen-centered pronucleophiles triggering cascade 1,4-addition/ Michael reaction through dynamic kinetic resolution under iminium catalysis. Development and mechanistic insights
(Royal Society of Chemistry, 2017-04-01)2-Hydroxydihydropyran-5-ones behave as excellent polyfunctional reagents able to react with enals through oxa-Michael/Michael process cascade under the combination of iminium and enamine catalysis. These racemic hemiacetalic ... -
Radiolabelling and preclinical evaluation of nanoparticles as drug delivery systems: application to infectious pulmonary diseases.
(2018-12-11)El trabajo llevado a cabo en esta tesis doctoral se ha dividido en tres partes, que corresponden a los capítulos 3,4 y 5 de la memoria. En la primera parte del trabajo, se presenta el desarrollo de una nueva herramienta ...