Browsing by Subject "GENETICS AND HEREDITY"
Now showing items 21-25 of 25
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Prioritization of candidate cancer genes-an aid to oncogenomic studies
(Oxford University Press, 2008-10)The development of techniques for oncogenomic analyses such as array comparative genomic hybridization, messenger RNA expression arrays and mutational screens have come to the fore in modern cancer research. Studies utilizing ... -
Radiotherapy plus nimotuzumab or placebo in the treatment of high grade glioma patients: results from a randomized, double blind trial
(BioMed Central, 2013-06-19)Background The prognosis of patients bearing high grade glioma remains dismal. Epidermal Growth Factor Receptor (EGFR) is well validated as a primary contributor of glioma initiation and progression. Nimotuzumab is a ... -
Snail heterogeneity in clear cell renal cell carcinoma
(Biomed Central, 2016-03-08)Background: Intratumor heterogeneity may be responsible of the unpredictable aggressive clinical behavior that some clear cell renal cell carcinomas display. This clinical uncertainty may be caused by insufficient sampling, ... -
Structural Basis for Feed-Forward Transcriptional Regulation of Membrane Lipid Homeostasis in Staphylococcus aureus
(Public Library of Science, 2013-01-03)The biosynthesis of membrane lipids is an essential pathway for virtually all bacteria. Despite its potential importance for the development of novel antibiotics, little is known about the underlying signaling mechanisms ... -
The Carpathian range represents a weak genetic barrier in South-East Europe
(Biomed Central, 2014-05-15)Background: In the present study we have assessed whether the Carpathian Mountains represent a genetic barrier in East Europe. Therefore, we have analyzed the mtDNA of 128 native individuals of Romania: 62 of them from the ...