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Now showing items 26393-26412 of 37862
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Novel Loci for Childhood Body Mass Index and Shared Heritability with Adult Cardiometabolic Traits
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; Bilbao Catalá, José Ramón
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; (Public Library Science, 2020-10-12)
The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed ... -
Novel Mean-Type Inequalities via Generalized Riemann-Type Fractional Integral for Composite Convex Functions: Some Special Examples
; ; ; ; ; De la Sen Parte, Manuel; (MDPI, 2023-02-10)
This study deals with a novel class of mean-type inequalities by employing fractional calculus and convexity theory. The high correlation between symmetry and convexity increases its significance. In this paper, we first ... -
Novel mechanisms for regulation of cell survival and migration by ceramide 1-phosphate
(2014-02-07)Ceramide 1-phosphate is a bioactive sphingolipid that regulates important cell functions, including cell proliferation, apoptosis, migration or inflammation. Cell homeostasis is essential for the normal development of any ... -
Novel Methodology for the Detection of Enveloped Viruses
(MDPI, 2020-06-15)Viral infections in humans cause a huge burden in worldwide healthcare that has increased due to the emergence of new pathogenic viruses, such as in the recent Ebola virus (EBOV) outbreaks. Viral particles in body fluids ... -
Novel methods for stereocontrolled cycloaddition/dearomatization reactions under catalytic conditions
(2017-04-28)Los alcaloides son, en general, una familia de compuestos heterocíclicos de origen vegetal que incorporan átomos de nitrógeno en su compleja estructura. Su interés recae en las interesantes actividades biológicas que ... -
Novel multivariate methods to track frequency shifts of neural oscillations in EEG/MEG recordings
(ELSEVIER, 2023)Instantaneous and peak frequency changes in neural oscillations have been linked to many perceptual, motor, and cognitive processes. Yet, the majority of such studies have been performed in sensor space and only occasion- ally ... -
Novel nanostructured lipid carriers based on Ω-3 polyunsaturated fatty acids and TAT peptide for neurodegenerative disease treatment
(2020-12-14)Neurodegenerative diseases (NDs) are an accelerating global problem, but we still lack routes to develop effective therapeutics. In this quest, it is crucial to identify novel drug candidates or drug carriers, which cross ... -
Novel organized multi-enzyme systems based on protein scaffolding
(2023-09-29)Este trabajo presenta tres estrategias versátiles para organizar sistemas multi-enzimáticos mediante el diseño de proteínas, creando andamiajes que combinan la organización espacial con la captura específica de intermediarios ... -
Novel Papillomaviruses in Free-Ranging Iberian Bats: No Virus-Host Co-evolution, No Strict Host Specificity, and Hints for Recombination
García Pérez, Raquel; Ibáñez, Carlos; Godínez, José M.; Aréchiga, Nidia; Garín Atorrasagasti, Ignacio; Pérez Suárez, Gonzalo; De Paz, Oscar; Juste, Javier; Echevarría, Juan E.; Bravo, Ignacio G. (Oxford University Press, 2014)
Papillomaviruses (PVs) are widespread pathogens. However, the extent of PV infections in bats remains largely unknown. This work represents the first comprehensive study of PVs in Iberian bats. We identified four novel PVs ... -
Novel phosphine sulphide gold(I) complexes: topoisomerase I inhibitors and antiproliferative agents
; ; ; ; Rubiales Alcaine, María Gloria; ; Palacios Gambra, Francisco Javier ; Alonso Pérez, Concepción Estibaliz (RSC, 2020-05-20)
This work describes the synthesis of the gold(I) complexes of phosphine sulphides. The formation of these new derivatives has been confirmed by X-ray crystallography. The coordination of gold(I) with the sulphur atom of ... -
Novel Pixelwise Co-Registered Hematoxylin-Eosin and Multiphoton Microscopy Image Dataset for Human Colon Lesion Diagnosis
Picón Ruiz, Artzai; Terradillos Fernández, Elena; Sánchez Peralta, Luisa F.; Mattana, Sara; Cicchi, Riccardo; Blover, Benjamin J.; Arbide del Río, Nagore; Velasco Arteche, Jacques; Etxezarraga Zuluaga, María Carmen; Pavone, Francesco S.; Garrote Contreras, Estíbaliz; López Saratxaga, Cristina (Elsevier, 2022-02-07)
Colorectal cancer presents one of the most elevated incidences of cancer worldwide. Colonoscopy relies on histopathology analysis of hematoxylin-eosin (H&E) images of the removed tissue. Novel techniques such as multi-photon ... -
Novel Population Pharmacokinetic Model for Linezolid in Critically Ill Patients and Evaluation of the Adequacy of the Current Dosing Recommendation
; ; ; ; ; Isla Ruiz, Arantxazu; (MDPI, 2020-01-09)
Antimicrobial treatment in critically ill patients remains challenging. The aim of this study was to develop a population pharmacokinetic model for linezolid in critically ill patients and to evaluate the adequacy of ... -
Novel proteomic and lipidomic biomarkers for limbal epithelial stem cell identification and corneal transplant monitoring
(2022-07-28)El objeto de esta tesis doctoral ha sido la caracterización proteómica y lipidómica de cinco poblaciones celulares de la córnea humana para la identificación de nuevos biomarcadores de cada tipo celular. Además, se han ... -
Novel redox active porous polymers to use as cathode in batteries
(2020-10-16)[EN]Currently, several organic materials and polymers are under investigationas cathode materials for lithium batteries, for example: organic carbonyl compounds, conductive polymers, radical polymers ... -
Novel Sol-Gel Route to Prepare Eu3+-Doped 80SiO2-20NaGdF4 Oxyfluoride Glass-Ceramic for Photonic Device Applications
; ; ; ; ; Balda de la Cruz, Rolindes; (MDPI, 2023-03-05)
Oxyfluoride glass-ceramics (OxGCs) with the molar composition 80SiO2-20(1.5Eu3+: NaGdF4) were prepared with sol-gel following the “pre-crystallised nanoparticles route” with promising optical results. The preparation of ... -
Novel Stereoselective Transformations under Lewis Base Catalysis
(2020-07-17)Dada la necesidad de las empresas farmacéuticas de comercializar compuestos enantioméricamente puros, la síntesis de moléculas enantiopuras ha atraído mucho interés en los últimos años. La síntesis asimétrica y en concreto, ... -
Novel strategies for the preparation of 13N-labelled compounds: Synthesis of 13N-labelled Aromatic azides, triazoles and tetrazoles
(2017-06-01)La Tomografía por Emisión de Positrones (PET) es una técnica de imagen molecular que permite conocer, de manera mínimamente invasiva y prácticamente a tiempo real, la distribución espacio-temporal de un radiotrazador marcado ... -
Novel studies on enamine and acid organocatalysis on carbon-carbon bond forming reactions
(2016-03-11)Los cicloaductos derivados de prolina no naturales densamente funcionalizados NO2-XL-OMe 5aa y NO2 NL-OMe 5aa poseen un gran interés en los campos de la química y biología ya que pueden complementar a los aminoácidos ... -
Novel studies on organocatalytic and stoichiometric C-C bond forming reactions
(2019-01-28)Las diferentes generaciones de organocatalizadores basadas en prolinas no naturales han demostrado ser muy eficientes a la hora de catalizar reacciones de formación de enlaces carbono-carbono como la reacción aldólica y ... -