Browsing by Author "Calderón, Marcelo"
Now showing items 1-15 of 15
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A Dual Fluorescence-Spin Label Probe for Visualization and Quantification of Target Molecules in Tissue by Multiplexed FLIM-EPR Spectroscopy
Dong, Pin; Stellmacher, Johannes; Bouchet, Lydia M.; Nieke, Marius; Kumar, Amit; Osorio Blanco, Ernesto Rafael; Nagel, Gregor; Lohan, Silke B.; Teutloff, Christian; Patzelt, Alexa; Schäfer-Korting, Monika; Calderón, Marcelo; Meinke, Martina C.; Alexiev, Ulrike (Wiley, 2021-06-25)Simultaneous visualization and concentration quantification of molecules in biological tissue is an important though challenging goal. The advantages of fluorescence lifetime imaging microscopy (FLIM) for visualization, ... -
A hybrid thermoresponsive plasmonic nanogel designed for NIR-mediated chemotherapy
Bergueiro, Julián; Glitscher, Emanuel A.; Calderón, Marcelo (Elsevier, 2022-06)Temperature-trigger chemotherapy is one of the state-of-the-art anti-tumoral strategies in nanomedicine. However, this strategy is in close relationship with the effect of the temperature in the tumor tissue. With high ... -
Bioadhesive eutectogels supporting drug nanocrystals for long-acting delivery to mucosal tissues
Bianchi, María Beatrice; Zhang, Chunyang; Catlin, Elise; Sandri, Giuseppina; Calderón, Marcelo; Larrañeta, Eneko; Donnelly, Ryan F.; Picchio, Matías L.; Paredes, Alejandro J. (Elsevier, 2022-12)utectogels (Egels) are an emerging class of soft ionic materials outperforming traditional temperature-intolerant hydrogels and costly ionogels. Due to their excellent elasticity, non-volatile nature, and adhesion properties, ... -
Dermal Delivery of the High-Molecular-Weight Drug Tacrolimus by Means of Polyglycerol-Based Nanogels
Rancan, Fiorenza; Volkmann, Hildburg; Giulbudagian, Michael; Schumacher, Fabian; Stanko, Jessica Isolde; Kleuser, Burkhard; Blume Peytavi, Ulrike; Calderón, Marcelo; Vogt, Annika (MDPI, 2019-08)Polyglycerol-based thermoresponsive nanogels (tNGs) have been shown to have excellent skin hydration properties and to be valuable delivery systems for sustained release of drugs into skin. In this study, we compared the ... -
Development of nanomaterials to overcome the mucosal barrier modulating their mucoadhesion and mucopenetration properties
Carrera Castro, Iker (2023-10-09)The aim of this work is to synthesize and develop polymeric nanoparticles (NP) that are able to interact with mucosal tissue for potential drug delivery. It is hypothesized that the NPs will be successfully functionalized ... -
Fine-tuning the properties of hybrid hydrogels to modulate their interactions with biological fluids:A systematic study at different length scales.
Esporrín Ubieto, David (2022-09-28)Durante las últimas décadas, los materiales a escala nano y micro han captado la especial atención de la comunidad científica. Durante el S.XX, emergieron un gran número de metodologías que permitían funcionalizar polímeros. ... -
Influence of Alkyl Chains of Modified Polysuccinimide‐Based Polycationic Polymers on Polyplex Formation and Transfection
Kravicz, Marcelo H.; Balogh, Debora T.; Kar, Mrityunjoy; Wedepohl, Stefanie; Bentley, Maria Vitoria L. B.; Calderón, Marcelo (Wiley, 2019-10)The development of polymers with low toxicity and efficient gene delivery remains a significant barrier of nonviral gene therapy. Modification and tuning of chemical structures of carriers is an attractive strategy for ... -
Nanocarriers for Skin Applications: Where Do We Stand?
Tiwari, Neha; Osorio Blanco, Ernesto Rafael; Sonzogni, Ana; Esporrín Ubieto, David; Wang, Huiyi; Calderón, Marcelo (Wiley, 2022-01)Skin penetration of active molecules for treatment of diverse diseases is a major field of research owing to the advantages associated with the skin like easy accessibility, reduced systemic-derived side effects, and ... -
One stone, many birds: Recent advances in functional nanogels for cancer nanotheranostics
Wang, Huiyi; Picchio, Matías L.; Calderón, Marcelo (Wiley, 2022-07)Inspired by the development of nanomedicine and nanotechnology, more and more possibilities in cancer theranostic have been provided in the last few years. Emerging therapeutic modalities like starvation therapy, chemodynamic ... -
Polyglutamic acid-based Crosslinked Doxorubicin Nanogels as an Anti-Metastatic Treatment for Triple Negative Breast Cancer
Duro-Castano, Aroa; Sousa-Herves, Ana; Armiñán, Ana; Charbonnier, David; Arroyo-Crespo, Juan José; Wedepohl, Stefanie; Calderón, Marcelo; Vicent, María J. (Elsevier, 2021-02-13)Treatment of triple negative breast cancer (TNBC)-associated metastasis represents an unmet clinical need, and we lack effective therapeutics for a disease that exhibits high relapse rates and associates with poor patient ... -
Polymer Colloids: Current Challenges, Emerging Applications, and New Developments
Aguirre Arrese, Miren ; Ballard, Nicholas ; González Gandara, Edurne; Hamzehlou, Shaghayegh; Sardon Muguruza, Haritz; Calderón, Marcelo; Paulis Lumbreras, María; Tomovska, Radmila; Dupin, Damien; Bean, Ren H.; Long, Timothy E.; Leiza Recondo, José Ramón; Asua González, José María (American Chemical Society, 2023-03)Polymer colloids are complex materials that have the potential to be used in a vast array of applications. One of the main reasons for their continued growth in commercial use is the water-based emulsion polymerization ... -
Recent advances and future perspectives on porous materials for biomedical applications
Orellano, Maria Soledad; Sanz Iturralde, Oihane ; Camarero Espinosa, Sandra; Beloqui Elizazu, Ana; Calderón, Marcelo (Future Medicine Ltd, 2022-01-13)... -
Stereocomplexed PLA microspheres: Control over morphology, drug encapsulation and anticancer activity
Brzeziński, M.; Kost, B.; Wedepohl, S.; Socka, M.; Biela, T.; Calderón, Marcelo (Elsevier, 2019-12-01)Lung cancer is the leading cause of cancer death because of smoking and air pollution. Therefore, new ideas should be provided for lung cancer treatment in which the delivery of anticancer drugs to the local tumor site can ... -
Synthesis and anisotropic growth of glycerol-based thermoresponsive NIR plasmonic nanogels
Glitscher, Emanuel A.; Bergueiro, Julián; Calderón, Marcelo (Elsevier, 2022-07)Polymeric thermoresponsive nanogels (NGs) have shown their potential in the field of nanomedicine. Providing their structure with additional smart modalities to broaden their application scope remains challenging. We hereby ... -
The influence of the shape of Au nanoparticles on the catalyticcurrent of fructose dehydrogenase
Bollella, Paolo; Hibino, Yuya; Conejo Valverde, Paolo; Soto Cruz, Jackeline; Bergueiro, Julián; Calderón, Marcelo; Rojas Carrillo, Oscar; Kano, Kenji; Gorton, Lo (Springer, 2019-11)Graphite electrodes were modified with triangular (AuNTrs) or spherical (AuNPs) nanoparticles and further modified with fructose dehydrogenase (FDH). The present study reports the effect of the shape of these nanoparticles ...