Browsing by Author "Cnop, Miriam"
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A long non-coding RNA that harbors a SNP associated with type 2 diabetes regulates the expression of TGM2 gene in pancreatic beta cells
González Moro, Itziar ; Rojas Márquez, Henar; Sebastián de la Cruz, Maialen ; Mentxaka Salgado, Jon; Olazagoitia Garmendia, Ane; Mendoza Gómez, Luis Manuel; Lluch, Aina; Fantuzzi, Federica; Lambert, Carmen; Ares Blanco, Jessica; Marselli, Lorella; Marchetti, Piero; Cnop, Miriam; Delgado, Elías; Fernández Real, José Manuel; Ortega, Francisco José; Castellanos Rubio, Ainara; Santín Gómez, Izortze (Frontiers Media, 2023-02)IntroductionMost of the disease-associated single nucleotide polymorphisms (SNPs) lie in non- coding regions of the human genome. Many of these variants have been predicted to impact the expression and function of long ... -
LncRNA ARGI Contributes to Virus-Induced Pancreatic β Cell Inflammation Through Transcriptional Activation of IFN-Stimulated Genes
González Moro, Itziar ; García Etxebarria, Koldo; Mendoza Gómez, Luis Manuel; Fernández Jiménez, Nora ; Mentxaka Salgado, Jon; Olazagoitia Garmendia, Ane; Nicol Arroyo, María; Sawatani, Toshiaki; Moreno Castro, Cristina; Vinci, Chiara; Op de Beek, Anne; Cnop, Miriam; Igoillo Esteve, Mariana; Santín Gómez, Izortze (Wiley, 2023-09)Type 1 diabetes (T1D) is a complex autoimmune disease that develops in genetically susceptible individuals. Most T1D-associated single nucleotide polymorphisms (SNPs) are located in non-coding regions of the human genome. ...