Browsing by Author "Coelho, Helena"
Now showing items 1-4 of 4
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Atomic and Specificity Details of Mucin 1 O-Glycosylation Process by Multiple Polypeptide GalNAc-Transferase Isoforms Unveiled by NMR and Molecular Modeling
Coelho, Helena; De las Rivas, Matilde; Grosso, Ana S.; Diniz, Ana; Soares, Cátia O.; Francisco, Rodrigo A.; Dias, Jorge S.; Compañón, Ismael; Sun, Lingbo; Narimatsu, Yoshiki; Vakhrushev, Sergey Y.; Clausen, Henrik; Cabrita, Eurico J.; Jiménez Barbero, Jesús ; Corzana, Francisco; Hurtado Guerrero, Ramón; Marcelo, Filipa (American Chemical Society, 2022-02-24)[EN] The large family of polypeptide GalNAc-transferases (GalNAc-Ts) controls with precision how GalNAc O-glycans are added in the tandem repeat regions of mucins (e.g., MUC1). However, the structural features behind the ... -
Novel carboxylate-based glycolipids: TLR4 antagonism, MD-2 binding and self-assembly properties
Cochet, Florent; Facchini, Fabio A.; Zaffaroni, Lenny; Billod, Jean-Marc; Coelho, Helena; Holgado, Aurora; Braun, Harald; Beyaert, Rudi; Jerala, Roman; Jiménez Barbero, Jesús ; Martin-Santamaria, Sonsoles; Peri, Francesco (Nature Publishing, 2019-01-29)New monosaccharide-based lipid A analogues were rationally designed through MD-2 docking studies. A panel of compounds with two carboxylate groups as phosphates bioisosteres, was synthesized with the same glucosamine-bis-succinyl ... -
Structural Characterization of N-Linked Glycans in the Receptor Binding Domain of the SARS-CoV-2 Spike Protein and their Interactions with Human Lectins
Lenza, Maria Pia; Oyenarte Santamaría, Iker; Diercks, Tammo; Quintana García, Jon Imanol; Gimeno, Ana; Coelho, Helena; Diniz, Ana; Peccati, Francesca; Delgado, Sandra; Bosch, Alexandre; Valle, Mikel; Millet Aguilar-Galindo, Oscar; Abrescia, Nicola A.G.; Palazón, Asís; Marcelo, Filipa; Jiménez Oses, Gonzalo; Jiménez Barbero, Jesús ; Ardá, Ana ; Ereño Orbea, June (Wiley, 2020-10)The glycan structures of the receptor binding domain of the SARS-CoV2 spike glycoprotein expressed in human HEK293F cells have been studied by using NMR. The different possible interacting epitopes have been deeply analysed ... -
Structures of the Inhibitory Receptor Siglec-8 in Complex with a High-Affinity Sialoside Analogue and a Therapeutic Antibody
Lenza, Maria Pia; Atxabal Arrasate, Unai; Nycholat, Corwin; Oyenarte Santamaría, Iker; Franconetti García, Antonio; Quintana García, Jon Imanol; Delgado, Sandra; Núñez Franco, Reyes; Garnica Marroquín, Carmen Teresa; Coelho, Helena; Unione, Luca; Jiménez Oses, Gonzalo; Marcelo, Filipa; Schubert, Mario; Paulson, James C.; Jiménez Barbero, Jesús ; Ereño Orbea, June (American Chemical Society, 2023-01)Human sialic acid binding immunoglobulin-like lectin-8 (Siglec-8) is an inhibitory receptor that triggers eosinophil apoptosis and can inhibit mast cell degranulation when engaged by specific monoclonal antibodies (mAbs) ...