BackBrowsing by Author "Cortázar, Ana Rosa"
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Identification of Androgen Receptor Metabolic Correlome Reveals the Repression of Ceramide Kinase by Androgens
; ; ; ; ; ; ; ; ; ; ; ; ; Carracedo Pérez, Arkaitz
(MDPI, 2021-08-26)
Prostate cancer (PCa) is one of the most prevalent cancers in men. Androgen receptor signaling plays a major role in this disease, and androgen deprivation therapy is a common therapeutic strategy in recurrent disease. ... -
Identification of proximal SUMO-dependent interactors using SUMO-ID
Barroso Gomila, Orhi; Trulsson, Erik; Muratore, Verónica; Canosa, Iñigo; Merino Cacho, Laura; Cortázar, Ana Rosa; Pérez Fernández, Coralia; ; Iloro, Ibon; Carracedo Pérez, Arkaitz; Aransay Bañares, Ana María; ; Mayor Martínez, Ugo ; Verteegal, Alfred C.O.; Barrio Olano, María Rosa; Sutherland, James D. (Nature Research, 2021-11-18)
[EN]The fast dynamics and reversibility of posttranslational modifications by the ubiquitin family pose significant challenges for research. Here we present SUMO-ID, a technology that merges proximity biotinylation by ... -
Integrative Analysis of Transcriptomics and Clinical Data Uncovers the Tumor- Suppressive Activity of MITF in Prostate Cancer
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; Carracedo Pérez, Arkaitz; (Nature Publishing Group, 2018-10-11)
The dysregulation of gene expression is an enabling hallmark of cancer. Computational analysis of transcriptomics data from human cancer specimens, complemented with exhaustive clinical annotation, provides an opportunity ... -
Metabolic alterations in urine extracellular vesicles are associated to prostate cancer pathogenesis and progression
; ; ; ; ; ; ; ; ; ; ; ; ; ; Carracedo Pérez, Arkaitz; (Taylor & Francis, 2018-05-07)
Urine contains extracellular vesicles (EVs) that concentrate molecules and protect them from degradation. Thus, isolation and characterisation of urinary EVs could increase the efficiency of biomarker discovery. We have ... -
Targeting PML in triple negative breast cancer elicits growth suppression and senescence
Arreal López, Leire; Piva, Marco; Fernández Ruiz, Sonia; Revandkar, Ajinkya; Schaub Clerigué, Ariane; Villanueva, Josep; Zabala Letona, Amaia; Pujana Vaquerizo, Mikel; Astobiza Pérez, Ianire; Cortázar, Ana Rosa; Hermanova, Ivana; Bozal Basterra, Laura; Arruabarrena Aristorena, Amaia; Crespo, Jana R.; Valcárcel Jiménez, Lorea; Zuñiga García, Patricia; Canals, Francesc; Torrano Moya, Verónica; Barrio Olano, María Rosa; Sutherland, James D.; Alimonti, Andrea; Martín Martín, Natalia; Carracedo Pérez, Arkaitz (Nature, 2020-04)
Oncogene addiction postulates that the survival and growth of certain tumor cells is dependent upon the activity of one oncogene, despite their multiple genetic and epigenetic abnormalities. This phenomenon provides a ...