Browsing by Author "Krenning, Lenno"

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      Chromosomes trapped in micronuclei are liable to segregation errors 

      Soto, Mar; García Santisteban, Iraia ORCID; Krenning, Lenno; Medema, René H.; Raaijmakers, Jonne A. (Company Biologist LTD, 2018-07-09)
      DNA in micronuclei is likely to get damaged. When shattered DNA from micronuclei gets reincorporated into the primary nucleus, aberrant rearrangements can take place, a phenomenon referred to as chromothripsis. Here, we ...
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      Sustained CHK2 activity, but not ATM activity, is critical to maintain a G1 arrest after DNA damage in untransformed cells 

      García Santisteban, Iraia ORCID; Llopis, Alba; Krenning, Lenno; Vallejo Rodríguez, Jon ORCID; Van den Broek, Bram; Zubiaga Elordieta, Ana María ORCID; Medem, René H. (BMC, 2021-02-19)
      BACKGROUND: The G1 checkpoint is a critical regulator of genomic stability in untransformed cells, preventing cell cycle progression after DNA damage. DNA double-strand breaks (DSBs) recruit and activate ATM, a kinase which ...