BackBrowsing by Author "López de Maturana, Rakel"
Now showing items 1-4 of 4
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iPS Cell Cultures from a Gerstmann-Sträussler-Scheinker Patient with the Y218N PRNP Mutation Recapitulate tau Pathology
(Humana Press, 2018-04)Gerstmann-Straussler-Scheinker (GSS) syndrome is a fatal autosomal dominant neurodegenerative prionopathy clinically characterized by ataxia, spastic paraparesis, extrapyramidal signs and dementia. In some GSS familiar ... -
LRRK2 Expression is Deregulated in Fibroblasts and Neurons from Parkinson Patients with Mutations in PINK1
Azkona, Garikoitz
; ; ; ; ; ; ; ; ; ; ; (Springer, 2018)
Mutations in PINK1 (PARK6), a serine/threonine kinase involved in mitochondrial homeostasis, are associated with early onset Parkinson's disease. Fibroblasts from Parkinson's disease patients with compound heterozygous ... -
Mutations in LRRK2 impair NF-κB pathway in iPSC-derived neurons
(Biomed Central, 2016-11-18)Background: Mutations in leucine-rich repeat kinase 2 (LRRK2) contribute to both familial and idiopathic forms of Parkinson's disease (PD). Neuroinflammation is a key event in neurodegeneration and aging, and there is ... -
Sustained increase of PKA activity in the post-commissural putamen of dyskinetic monkeys
Azkona, Garikoitz; ; ; ; ; ; (Springer, 2014-04-05)
Levodopa-induced dyskinesias (LID) are a frequent complication of Parkinson's disease pharmacotherapy that causes significant disability and narrows the therapeutic window. Pharmacological management of LID is challenging ...