Browsing by Author "Naaldijk, Yahaira"

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      Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement 

      Fernández, Elena; Madero-Pérez, Jesús; Lara Ordóñez, Antonio J.; Naaldijk, Yahaira; Fasiczka, Rachel; Aiastui, Ana; Ruiz-Martínez, Javier; López de Munain Arregui, Adolfo José; Cowley, Sally A.; Wade-Martins, Richard; Hilfiker, Sabine (Cell Press, 2022-06-17)
      Mutations in LRRK2 increase its kinase activity and cause Parkinson's disease. LRRK2 phosphorylates a subset of Rab proteins which allows for their binding to RILPL1. The phospho-Rab/RILPL1 interaction causes deficits in ...