Browsing by Author "O'Brien, Tim"

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      Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal 

      Turajlic, Samra; Xu, Hang; Litchfield, Kevin; Rowan, Andrew; Horswell, Stuart; Chambers, Tim; O'Brien, Tim; López Fernández de Villaverde, José Ignacio ORCID; Watkins, Thomas B. K.; Nicol, David; Stares, Mark; Challacombe, Ben; Hazell, Steve; Chandra, Ashish; Mitchell, Thomas J.; Au, Lewis; Eichler-Jonsson, Claudia; Jabbar, Faiz; Soultati, Aspasia; Chowdhury, Simon; Rudman, Sarah; Lynch, Joanna; Archana Sinduri, Fernando; Stamp, Gordon; Nye, Emma; Stewart, Aengus; Xing, Wei; Smith, Jonathan C.; Escudero, Mickael; Huffman, Adam; Matthews, Nik; Elgar, Greg; Phillimore, Ben; Costa, Marta; Begum, Sharmin; Ward, Sophia; Salm, Max; Boeing, Stefan; Fisher, Rosalie; Spain, Lavinia; Navas, Carolina; Gronroos, Eva; Hobor, Sebastijan; Sharma, Sarkhara; Aurangzeb, Ismaeel; Lall, Sharanpreet; Polson, Alexander; Varia, Mary; Horsfield, Catherine; Fotiadis, Nicos; Pickering, Lisa; Schwarz, Roland F.; Silva, Bruno; Herrero, Javier; Luscombe, Nick M.; Jamal-Hanjani, Mariam; Rosenthal, Rachel; Birkbak, Nicolai J.; Wilson, Gareth A.; Pipek, Orsolya; Ribli, Dezso; Krzystanek, Marcin; Csabai, Istvan; Szállási, Zoltán; Gore, Martin E.; McGranahan, Nicholas; Van Loo, Peter; Campbell, Peter; Larkin, James; Swanton, Charles (Cell Press, 2018-04-19)
      The evolutionary features of clear-cell renal cell carcinoma (ccRCC) have not been systematically studied to date. We analyzed 1,206 primary tumor regions from 101 patients recruited into the multi-center prospective study, ...
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      Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal 

      Turajlic, Samra; Xu, Hang; Litchfield, Kevin; Rowan, Andrew; Chambers, Tim; López Fernández de Villaverde, José Ignacio ORCID; Nicol, David; O'Brien, Tim; Larkin, James; Horswell, Stuart; Stares, Mark; Au, Lewis; Jamal-Hanjani, Mariam; Challacombe, Ben; Chandra, Ashish; Hazell, Steve; Eichler-Jonsson, Claudia; Soultati, Aspasia; Chowdhury, Simon; Rudman, Sarah; Lynch, Joanna; Archana Sinduri, Fernando; Stamp, Gordon; Nye, Emma; Jabbar, Faiz; Spain, Lavinia; Lall, Sharanpreet; Guarch, Rosa; Falzon, Mary; Proctor, Ian; Pickering, Lisa; Gore, Martin E.; Watkins, Thomas B. K.; Ward, Sophia; Stewart, Aengus; DiNatale, Renzo; Becerra, Maria F.; Reznik, Ed; Hsieh, James J.; Richmond, Todd A.; Mayhew, George F.; Hill, Samantha M.; McNally, Catherine D.; Jones, Carol; Rosenbaum, Heidi; Stanislaw, Stacey; Burgess, Daniel L.; Alexander, Nelson R.; Swanton, Charles (Cell Press, 2018-04-19)
      Clear-cell renal cell carcinoma (ccRCC) exhibits a broad range of metastatic phenotypes that have not been systematically studied to date. Here, we analyzed 575 primary and 335 metastatic biopsies across 100 patients with ...