BackBrowsing by Author "Penas Lago, Cristina"
Now showing items 1-6 of 6
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BRAF V600E mutational load as a prognosis biomarker in malignant melanoma
Sevilla Mambrilla, Arrate
; ; Ezcurra García Unzueta, Pilar Ariadna ; ; ; ; ; ; ; ; Asumendi Mallea, Aintzane ; ; Boyano López, María Dolores ; Alonso Alegre, Santos (Public Library Science, 2020-03-13)
Analyzing the mutational load of driver mutations in melanoma could provide valuable information regarding its progression. We aimed at analyzing the heterogeneity of mutational load of BRAF V600E in biopsies of melanoma ... -
Melanoma Clinical Decision Support System: An Artificial Intelligence-Based Tool to Diagnose and Predict Disease Outcome in Early-Stage Melanoma Patients
; ; ; ; ; Apraiz García, Aintzane; ; ; ; ; ; ; ; Sevilla Mambrilla, Arrate ; ; ; ; Alonso Alegre, Santos ; Asumendi Mallea, Aintzane ; Boyano López, María Dolores (MDPI, 2023-04-06)
This study set out to assess the performance of an artificial intelligence (AI) algorithm based on clinical data and dermatoscopic imaging for the early diagnosis of melanoma, and its capacity to define the metastatic ... -
Pirin is a prognostic marker of human melanoma that dampens the proliferation of malignant cells by downregulating JARID1B/KDM5B expression
; ; Apraiz García, Aintzane; ; Muñoa Hoyos, Iraia ; Andollo Victoriano, María Noelia ; ; ; ; Ezcurra García Unzueta, Pilar Ariadna ; Subirán Ciudad, Nerea ; ; Alonso Alegre, Santos ; ; Asumendi Mallea, Aintzane ; Boyano López, María Dolores (Nature, 2023-06)
Originally considered to act as a transcriptional co‑factor, Pirin has recently been reported to play a role in tumorigenesis and the malignant progression of many tumors. Here, we have analyzed the diagnostic and ... -
RKIP Regulates Differentiation-Related Features in Melanocytic Cells
; Apraiz García, Aintzane; Muñoa Hoyos, Iraia ; ; ; Ezcurra García Unzueta, Pilar Ariadna ; ; Subirán Ciudad, Nerea ; ; Alonso Alegre, Santos ; Asumendi Mallea, Aintzane ; Boyano López, María Dolores (MDPI, 2020-06-03)
Raf Kinase Inhibitor Protein (RKIP) has been extensively reported as an inhibitor of keysignaling pathways involved in the aggressive tumor phenotype and shows decreased expressionin several types of cancers. However, ... -
Role of RKIP and Pirin in the malignant progression of cutaneous melanoma. New diagnosis and prognosis biomarkers
(2022-09-23)Melanoma is an extremely lethal skin cancer that arises as a result of the malignant transformation of melanocytes. The incidence of this pathology worldwide has increased in the last 30 years in greater proportion than ... -
Serum markers improve current prediction of metastasis development in early-stage melanoma patients: a machine learning-based study
; ; ; ; Apraiz García, Aintzane; Pérez-Yarza Pérez-Irezabal, Gorka ; Ezcurra García Unzueta, Pilar Ariadna ; ; ; ; ; ; ; ; Asumendi Mallea, Aintzane ; Boyano López, María Dolores (Wiley, 2020-06)
Metastasis development represents an important threat for melanoma patients, even when diagnosed at early stages and upon removal of the primary tumor. In this scenario, determination of prognostic biomarkers would be of ...