BackBrowsing by Author "Perugorria Montiel, María Jesús"
Now showing items 1-18 of 18
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Anti-miR-518d-5p Overcomes Liver Tumor Cell Death Resistance Through Mitochondrial Activity
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; Bañales Asurmendi, Jesús María
; ; ; ; ; ; ; Martínez Chantar, María Luz (Springer Nature, 2021-05-28)
Dysregulation of miRNAs is a hallmark of cancer, modulating oncogenes, tumor suppressors, and drug responsiveness. The multi-kinase inhibitor sorafenib is one of the first-line drugs for advanced hepatocellular carcinoma ... -
Cholangiocarcinoma 2020: the next horizon in mechanisms and management
Bañales Asurmendi, Jesús María; ; ; ; ; ; ; ; Andersen, Jesper B.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; (Springer Nature, 2020-06-30)
[EN] Cholangiocarcinoma (CCA) includes a cluster of highly heterogeneous biliary malignant tumours that can arise at any point of the biliary tree. Their incidence is increasing globally, currently accounting for ~15% ... -
Extracellular Vesicles in Hepatobiliary Malignancies
; ; ; ; Bujanda Fernández de Pierola, Luis; ; Bañales Asurmendi, Jesús María (Frontiers Media, 2018-10-12)
Primary hepatobiliary malignancies include a heterogeneous group of cancers with dismal prognosis, among which hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA), and hepatoblastoma (HB) stand out. These tumors mainly ... -
FOSL1 promotes cholangiocarcinoma via transcriptional effectors that could be therapeutically targeted
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; Ávila, Matías A.; ; ; ; ; Bañales Asurmendi, Jesús María ; (Elsevier, 2021-04-20)
[EN] Background & Aims: Cholangiocarcinoma (CCA) is a neoplasia of the biliary tract driven by genetic, epigenetic and transcriptional mechanisms. Herein, we investigated the role of the transcription factor FOSL1, as ... -
Inhibition of NAE-dependent protein hyper-NEDDylation in cystic cholangiocytes halts cystogenesis in experimental models of polycystic liver disease
; ; Caballero Camino, Francisco Javier; ; Rodrigues, Pedro M.; Perugorria Montiel, María Jesús; ; ; Martínez Chantar, María Luz ; ; Bujanda Fernández de Pierola, Luis ; Drenth, Joost P. H.; Bañales Asurmendi, Jesús María (Sage, 2021-09)
Background Polycystic liver diseases (PLDs) are genetic inherited disorders characterized by the progressive growth of numerous intrahepatic biliary cysts, which are the main cause of morbidity. Previous studies revealed ... -
m6A Methylated Long Noncoding RNA LOC339803 Regulates Intestinal Inflammatory Response
; ; Sebastián de la Cruz, Maialen; ; ; ; ; Bujanda Fernández de Pierola, Luis ; ; ; (Wiley, 2024-04)
Cytokine mediated sustained inflammation increases the risk to develop different complex chronic inflammatory diseases, but the implicated mechanisms remain unclear. Increasing evidence shows that long noncoding RNAs ... -
Novel equation to determine the hepatic triglyceride concentration in humans by MRI: diagnosis and monitoring of NAFLD in obese patients before and after bariatric surgery
Jiménez Agüero, Raúl; Emparanza, José Ignacio; Beguiristain Gómez, Adolfo; Bujanda Fernández de Pierola, Luis; Alustiza Echeberria, José María; García, Elisabeth; Hijona Muruamendiaraz, Elizabeth; Gallego, Lander; Sanchez Gonzalez, Javier; Perugorria Montiel, María Jesús; Asensio, José I; Larburu Echaniz, Santiago; Garmendia Antin, Maddi ; Larzabal, Mikel; Portillo Baquedano, María Puy ; Aguirre López, Leixuri ; Bañales Asurmendi, Jesús María (Biomed Central, 2014-08-26)
Background: Non-alcoholic fatty liver disease (NAFLD) is caused by abnormal accumulation of lipids within liver cells. Its prevalence is increasing in developed countries in association with obesity, and it represents a ... -
Novel insights in the pathogenesis of primary biliary cholangitis and cholangiocarcinoma
(2017-06-23)Este trabajo de tesis doctoral se centra en el estudio de dos enfermedades biliares: la colangitis biliar primaria (del inglés primary biliary cholangitis, PBC) y el colangiocarcinoma (CCA).Por un lado, ya que el miR-506 ... -
Patients with Cholangiocarcinoma Present Specific RNA Profiles in Serum and Urine Extracellular Vesicles Mirroring the Tumor Expression: Novel Liquid Biopsy Biomarkers for Disease Diagnosis
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; Bujanda Fernández de Pierola, Luis; ; Andersen, Jesper B.; ; ; Bañales Asurmendi, Jesús María (MDPI, 2020-03-14)
Cholangiocarcinoma (CCA) comprises a group of heterogeneous biliary cancers with dismal prognosis. The etiologies of most CCAs are unknown, but primary sclerosing cholangitis (PSC) is a risk factor. Non-invasive diagnosis ... -
Role of endoplasmic reticulum stress in the pathogenesis of polycystic liver disease: new potential therapeutic target
(2019-11-29)La enfermedad hepática poliquística (PLD) abarca un grupo heterogéneo de colangiopatías genéticas caracterizadaspor la dilatación del conducto biliar y el desarrollo de múltiples quistes biliares intrahepáticos (>10), que ... -
Role of TREM2 receptor during the progression of liver disease; from acute liver injury, to chronic liver disease and the development of hepatocellular carcinoma (HCC).
Esparza Baquer, Aitor (2018-12-17)
La lesión e inflamación hepática y el desarrollo del carcinoma hepatocelular (HCC) se modulan en parte a través de la señalización de los receptores de tipo Toll (TLR). El receptor TREM2 (triggering receptor expressed on ... -
Synthetic Conjugates of Ursodeoxycholic Acid Inhibit Cystogenesis in Experimental Models of Polycystic Liver Disease
Caballero Camino, Francisco Javier; Rivilla de la Cruz, Iván ; Herráez Aguilar, Elisa; Briz Sánchez, Oscar; Santos Laso, Álvaro; ; ; Rodrigues, Pedro M.; Muñoz Garrido, Patricia; Jin, Sujeong; Peixoto, Estanislao; Richard, Seth; Gradilone, Sergio A.; Perugorria Montiel, María Jesús; Esteller, Manel; Bujanda Fernández de Pierola, Luis ; Marin, José J. G.; Bañales Asurmendi, Jesús María ; Cossío Mora, Fernando Pedro (Wiley, 2020-09-22)
Background and Aims Polycystic liver diseases (PLDs) are genetic disorders characterized by progressive development of symptomatic biliary cysts. Current surgical and pharmacological approaches are ineffective, and liver ... -
Targeting UBC9-Mediated Protein Hyper-SUMOylation in Cystic Cholangiocytes Halts Polycystic Liver Disease in Experimental Models
; ; Caballero Camino, Francisco Javier; ; ; ; ; ; Martínez Chantar, María Luz ; ; ; ; ; Bujanda Fernández de Pierola, Luis ; ; Bañales Asurmendi, Jesús María (Elsevier, 2021-02)
BACKGROUND & AIMS: Polycystic liver diseases (PLDs) are genetic disorders characterized by progressive development of multiple fluid-filled biliary cysts. Most PLD-causative genes participate in protein biogenesis and/or ... -
The role of protein NEDDylation in the pathogenesis of cholangiocarcinoma: new potential therapeutic target
(2021-01-29)Las modificaciones post-traduccionales son mecanismos esenciales para la modulación de respuestas celulares a diversos estímulos. La relevancia de la NEDDilación de proteínas en particular se ha demostrado en distintas ... -
The role of scavenger receptor MARCO in the immuno-oncology of intrahepatic cholangiocarcinoma: a novel prognostic and therapeutic target
(2023-03-03)El colangiocarcinoma (CCA) es un conjunto de tumores que se originan en la vía biliar y debido a su carácter asintomático, se diagnostican en fases muy avanzadas, limitando sustancialmente las posibles opciones terapéuticas. ... -
The role of TREM-2 receptor in cholestasis and fibrosis-associated hepatocellular carcinoma (HCC)
(2020-12-18)La progresión de enfermedades hepatobiliares crónicas, tales como las enfermedades colestásicas (entrelas que destacan la colangitis biliar primaria y la colangitis esclerosante primaria), así como el carcinomahepatocelular ... -
TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms
Esparza Baquer, Aitor; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; Andersen, Jesper B.; ; ; Bujanda Fernández de Pierola, Luis ; Bañales Asurmendi, Jesús María ; (BMJ Publishing Group, 2021-06-07)
[EN] Objective Hepatocellular carcinoma (HCC) is a prevalent and aggressive cancer usually arising on a background of chronic liver injury involving inflammatory and hepatic regenerative processes. The triggering receptor ... -
TREM-2 plays a protective role in cholestasis by acting as a negative regulator of inflammation
; ; ; ; ; ; Esparza Baquer, Aitor; ; ; ; ; ; ; ; ; ; ; ; ; Bujanda Fernández de Pierola, Luis ; (Elsevier, 2022-10)
Background & Aims: Inflammation, particularly that mediated by bacterial components translocating from the gut to the liver and binding to toll-like receptors (TLRs), is central to cholestatic liver injury. The triggering ...