BackBrowsing by Author "Sáenz Antoñanzas, Ander"
Now showing items 1-6 of 6
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High SOX9 Maintains Glioma Stem Cell Activity through a Regulatory Loop Involving STAT3 and PML
; ; ; ; ; ; ; ; ; ; ; ; Carracedo Pérez, Arkaitz
; (MDPI, 2022-05)
Glioma stem cells (GSCs) are critical targets for glioma therapy. SOX9 is a transcription factor with critical roles during neurodevelopment, particularly within neural stem cells. Previous studies showed that high levels ... -
Identification of molecular mechanisms underlying frailty and successful aging in centenarians
(2023-03-31)El envejecimiento es un proceso sistémico, multifactorial y degenerativo caracterizado por el declive y la pérdida de capacidades físicas y mentales. La esperanza media de vida ha aumentado considerablemente en el último ... -
Myotonic Dystrophy type 1 cells display impaired metabolism and mitochondrial dysfunction that are reversed by metformin
(Impact Journals, 2020-04-15)Myotonic dystrophy type 1 (DM1; MIM #160900) is an autosomal dominant disorder, clinically characterized by progressive muscular weakness and multisystem degeneration. The broad phenotypes observed in patients with DM1 ... -
PR-LncRNA Signature Regulates Glioma Cell Activity Through Expression of SOX Factors
; ; ; ; ; ; ; ; ; ; ; Ruiz Díaz, Irune; ; ; ; ; ; (Nature Publishing Group, 2018-08-24)
Long non-coding RNAs (LncRNAs) have emerged as a relevant class of genome regulators involved in a broad range of biological processes and with important roles in tumor initiation and malignant progression. We have previously ... -
Senescence plays a role in myotonic dystrophy type 1 br
(American Society for Clinical Investigation, 2022-10)Myotonic dystrophy type 1 (DM1; MIM #160900) is an autosomal dominant disorder, clinically characterized by progressive muscular weakness and multisystem degeneration. The broad phenotypes observed in patients with DM1 ... -
Targeting Myotonic Dystrophy Type 1 with Metformin
(MDPI, 2022-03)Myotonic dystrophy type 1 (DM1) is a multisystemic disorder of genetic origin. Progressive muscular weakness, atrophy and myotonia are its most prominent neuromuscular features, while additional clinical manifestations in ...