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      CLR01 Protects Dopaminergic Neurons in Vitro and in Mouse Models of Parkinson's Disease 

      Bengoa Vergniory, Nora; Faggiani, Emilie; Ramos González, Paula; Kirkiz, Ecem; Connor-Robson, Natalie; Brown, Liam V.; Siddique, Ibrar; Li, Zizheng; Vingill, Siv; Cioroch, Milena; Cavaliere, Fabio; Threlfell, Sarah; Roberts, Bradley; Schrader, Thomas; Klaerner, Frank-Gerrit; Cragg, Stephanie; Dehay, Benjamin; Bitan, Gal; Matute Almau, Carlos José; Bezard, Erwan; Wade-Martins, Richard (Nature, 2020-09-28)
      Parkinson's disease (PD) affects millions of patients worldwide and is characterized by alpha-synuclein aggregation in dopamine neurons. Molecular tweezers have shown high potential as anti-aggregation agents targeting ...
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      Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement 

      Fernández, Elena; Madero-Pérez, Jesús; Lara Ordóñez, Antonio J.; Naaldijk, Yahaira; Fasiczka, Rachel; Aiastui, Ana; Ruiz-Martínez, Javier; López de Munain Arregui, Adolfo José; Cowley, Sally A.; Wade-Martins, Richard; Hilfiker, Sabine (Cell Press, 2022-06-17)
      Mutations in LRRK2 increase its kinase activity and cause Parkinson's disease. LRRK2 phosphorylates a subset of Rab proteins which allows for their binding to RILPL1. The phospho-Rab/RILPL1 interaction causes deficits in ...