BackBrowsing by Author "Zabala Letona, Amaia"
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Identification of Androgen Receptor Metabolic Correlome Reveals the Repression of Ceramide Kinase by Androgens
; ; ; ; ; ; ; ; ; ; ; ; ; Carracedo Pérez, Arkaitz
(MDPI, 2021-08-26)
Prostate cancer (PCa) is one of the most prevalent cancers in men. Androgen receptor signaling plays a major role in this disease, and androgen deprivation therapy is a common therapeutic strategy in recurrent disease. ... -
Molecular and biological consequences of targeting polyamine metabolism in prostate cancer
(2023-03-31)The study of tumor metabolism has uncovered a new therapeutic window for the treatment of some cancer types. In such paradigm, cell signaling and metabolic reprogramming can act in tandem for the benefit of the cancer cell. ... -
PI3K-regulated Glycine N-methyltransferase is required for the development of prostate cancer
Zabala Letona, Amaia; Arruabarrena Aristorena, Amaia; Fernández Ruiz, Sonia; Viera, Cristina; Carlevaris, Onintza; Ercilla Eguiarte, Amaia; Mendizabal, Isabel; Martín Mateos, Teresa; Macchia, Alice; Camacho Soguero, Laura; Pujana Vaquerizo, Mikel; Sánchez Mosquera, Pilar; Torrano Moya, Verónica; Martín Martín, Natalia; Zuñiga García, Patricia; Castillo Martín, Mireia; Ugalde Olano, Aitziber; Loizaga Iriarte, Ana; Unda Urzaiz, Jesús Miguel; Mato, José M.; Berra Ramírez, Miren Edurne; Martínez Chantar, María Luz; Carracedo Pérez, Arkaitz (Springer Nature, 2022-02)
[EN] Glycine N-Methyltransferase (GNMT) is a metabolic enzyme that integrates metabolism and epigenetic regulation. The product of GNMT, sarcosine, has been proposed as a prostate cancer biomarker. This enzyme is predominantly ... -
Targeting PML in triple negative breast cancer elicits growth suppression and senescence
Arreal López, Leire; Piva, Marco; Fernández Ruiz, Sonia; Revandkar, Ajinkya; Schaub Clerigué, Ariane; Villanueva, Josep; Zabala Letona, Amaia; Pujana Vaquerizo, Mikel; Astobiza Pérez, Ianire; Cortázar, Ana Rosa; Hermanova, Ivana; Bozal Basterra, Laura; Arruabarrena Aristorena, Amaia; Crespo, Jana R.; Valcárcel Jiménez, Lorea; Zuñiga García, Patricia; Canals, Francesc; Torrano Moya, Verónica; Barrio Olano, María Rosa; Sutherland, James D.; Alimonti, Andrea; Martín Martín, Natalia; Carracedo Pérez, Arkaitz (Nature, 2020-04)
Oncogene addiction postulates that the survival and growth of certain tumor cells is dependent upon the activity of one oncogene, despite their multiple genetic and epigenetic abnormalities. This phenomenon provides a ...