BackExaminar por departamento (eus.) "Neurozientziak"
Now showing items 1-20 of 478
-
1-42 beta-Amyloid peptide requires PDK1/nPKC/Rac 1 pathway to induce neuronal death
; ; Ruiz Núñez, Asier
; ; Arrizabalaga Uriarte, Oskar ; ; Alberdi Alfonso, Elena María ; ; ; ; ; ; Zugaza Gurruchaga, José Luis (Nature Publishing Group, 2013-01)
1-42 beta-Amyloid (A beta(1-42)) peptide is a key molecule involved in the development of Alzheimer's disease. Some of its effects are manifested at the neuronal morphological level. These morphological changes involve ... -
2-Arakidonilglizerol endokannabinoidearen sintesi- eta degradazio-makineria neuronaren nukleoan: Diazilglizerol Lipasa alfa-ren konpartimentazioa eta aktibitate entzimatikoa
(2017-09-29)Ikerketa lan honetan, zatikapen azpizelularra, Western blot eta fluoreszentzia mikroskopia bidez, diazilglizerol lipasa ¿-ren (DAGL¿) presentzia frogatu dugu arratoi helduaren garun-kortexetik isolatutako nukleoetan. ... -
A 4-Trifluoromethyl Analogue of Celecoxib Inhibits Arthritis by Suppressing Innate Immune Cell Activation
(Biomed Central, 2012-01-17)Introduction: Celecoxib, a highly specific cyclooxygenase-2 (COX-2) inhibitor has been reported to have COX-2-independent immunomodulatory effects. However, celecoxib itself has only mild suppressive effects on arthritis. ... -
A beta oligomers promote oligodendrocyte differentiation and maturation via integrin beta 1 and Fyn kinase signaling
; ; ; ; ; ; Sánchez Gómez, María Victoria; ; Alberdi Alfonso, Elena María (Nature Publishing Group, 2019-06-06)
Alzheimer's disease (AD) is characterized by a progressive cognitive decline that correlates with the levels of amyloid beta-peptide (A beta) oligomers. Strong evidences connect changes of oligodendrocyte function with the ... -
A Clonal NG2-Glia Cell Response in a Mouse Model of Multiple Sclerosis
Barriola, Sonsoles; Pérez Cerdá, Fernando; ; Bribián, Ana; López Mascaraque, Laura (MDPI, 2020-05-21)
NG2-glia, also known as oligodendrocyte precursor cells (OPCs), have the potential to generate new mature oligodendrocytes and thus, to contribute to tissue repair in demyelinating diseases like multiple sclerosis (MS). ... -
A deep intronic splice variant advises reexamination of presumably dominant SPG7 Cases
(Wiley, 2020-01)Objective To identify causative mutations in a patient affected by ataxia and spastic paraplegia. Methods Whole-exome sequencing (WES) and whole-genome sequencing (WGS) were performed using patient's DNA sample. RT-PCR and ... -
A functional variant that affects exon-skipping and protein expression of SP140 as genetic mechanism predisposing to multiple sclerosis
(Oxford University Pres, 2015-10-01)Several variants in strong linkage disequilibrium (LD) at the SP140 locus have been associated with multiple sclerosis (MS), Crohn's disease (CD) and chronic lymphocytic leukemia (CLL). To determine the causal polymorphism, ... -
A Genotyping Method Combining Primer Competition PCR with HRM Analysis to Identify Point Mutations in Duchenne Animal Models
Lasa Fernández, Haizpea; ; ; ; Vallejo Illarramendi, Ainara (Nature, 2020-10-14)
Dystrophin-null sapje zebrafish is an excellent model for better understanding the pathological mechanisms underlying Duchenne muscular dystrophy, and it has recently arisen as a powerful tool for high-throughput screening ... -
A Model of Ischemia-Induced Neuroblast Activation in the Adult Subventricular Zone
Vergni, Davide; Castiglione, Filippo; Briani, Maya; Middei, Silvia; Alberdi Alfonso, Elena María; Reymann, Klaus G.; Natalini, Roberto; Volonté, Cinzia; ; Cavaliere, Fabio (Public Library of Science, 2009-04-23)
We have developed a rat brain organotypic culture model, in which tissue slices contain cortex-subventricular zone-striatum regions, to model neuroblast activity in response to in vitro ischemia. Neuroblast activation has ... -
A Multicentre, Randomised, Controlled Trial of a Combined Clinical Treatment for First-Episode Psychosis
; ; Echeburúa Odriozola, Enrique; Alberich, Susana ; ; ; ; ; ; ; ; ; ; González Pinto Arrillaga, Ana María (MDPI, 2021-07-06)
Introduction: There is evidence that early intervention contributes to improving the prognosis and course of first-episode psychosis (FEP). However, further randomised treatment clinical trials are needed. Objectives: The ... -
A neural extracellular matrix-based method for in vitro hippocampal neuron culture and dopaminergic differentiation of neural stem cells
García Parra, Patricia; Maroto, Marcos; Cavaliere, Fabio; Naldaiz Gastesi, Neia; Álava, José I.; García, Antonio G.; López de Munain Arregui, Adolfo José; Izeta Permisán, Ander (BioMed Central, 2013)
Background: The ability to recreate an optimal cellular microenvironment is critical to understand neuronal behavior and functionality in vitro. An organized neural extracellular matrix (nECM) promotes neural cell ... -
A Neuron, Microglia, and Astrocyte Triple Co-culture Model to Study Alzheimer’s Disease
Luchena Moreno, Celia; ; ; ; Alberdi Alfonso, Elena María ; Capetillo González de Zarate, Estíbaliz (Frontiers Media, 2022-04-14)
Glial cells are essential to understand Alzheimer's disease (AD) progression, given their role in neuroinflammation and neurodegeneration. There is a need for reliable and easy to manipulate models that allow studying the ... -
A new approach based on targeted pooled DNA sequencing identifies novel mutations in patients with Inherited Retinal Dystrophies
(Nature Publishing, 2018-09-18)Inherited retinal diseases (IRD) are a heterogeneous group of diseases that mainly affect the retina; more than 250 genes have been linked to the disease and more than 20 different clinical phenotypes have been described. ... -
A nonlinear meccano for Alzheimer's emergence by amyloid β-mediated glutamatergic hyperactivity
(Elsevier, 2024-05)The pathophysiological process of Alzheimer's disease (AD) is believed to begin many years before the formal diagnosis of AD dementia. This protracted preclinical phase offers a crucial window for potential therapeutic ... -
A novel form of human disease with a protease-sensitive prion protein and heterozygosity methionine/valine at codon 129: Case report
Rodríguez Martínez, Ana B.; Garrido Urkullu, Joseba M.; Zarranz Imirizaldu, Juan José; Arteagoitia, Jose M.; Martínez de Pancorbo Gómez, María de los Angeles; Atares, Begona; Bilbao, Miren J.; Ferrer, Isidro; Juste Jordán, Ramón A. (BioMed Central, 2010-10)
Background: Sporadic Creutzfeldt-Jakob disease (sCJD) is a rare neurodegenerative disorder in humans included in the group of Transmissible Spongiform Encephalopathies or prion diseases. The vast majority of sCJD cases are ... -
A qualitative research of adolescents with behavioral problems about their experience in a dialectical behavior therapy skills training group
; ; ; ; ; ; Catalán Alcántara, Ana; ; ; González Torres, Miguel Ángel (BMC, 2020-05-19)
BACKGROUND: Several quantitative studies support the effectiveness of the Dialectical Behavior Therapy (DBT) psychosocial skills training group component for adolescents with impulse-control disorder and/or emotional ... -
A systematic review of sex-based differences in effectiveness and adverse effects of clozapine
Alberich, Susana; ; ; Usall, Judith; Sáenz Herrero, Margarita; González Fraile, Eduardo; González Pinto Arrillaga, Ana María (Elsevier, 2019-08-03)
Clozapine is one of the most widely used antipsychotics for treating psychiatric illnesses such as schizophrenia and bipolar disorder. This drug, however, is associated with adverse effects such as weight gain, metabolic ... -
A Trifluoromethyl Analogue of Celecoxib Exerts Beneficial Effects in Neuroinflammation
(Public Library of Science, 2013-12-11)Celecoxib is a selective cyclooxygenase-2 (COX2) inhibitor. We have previously shown that celecoxib inhibits experimental autoimmune encephalomyelitis (EAE) in COX-2-deficient mice, suggestive for a mode of action involving ... -
Acetylome in Human Fibroblasts From Parkinson's Disease Patients
(Frontiers Media SA, 2018-04-17)Parkinson's disease (PD) is amultifactorial neurodegenerative disorder. The pathogenesis of this disease is associated with gene and environmental factors. Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most ... -
Adaptación de un sistema de propagación de priones in vitro para el cribado masivo de compuestos específicos frente a las Encefalopatías Espongiformes Transmisibles humanas
(2020-09-11)Las Encefalopatías Espongiformes Transmisibles (EET) son un conjunto de desórdenes neurodegenerativos mortales que afectan a varios mamíferos incluidos los humanos, cuyo agente causante es una isoforma anormalmente plegada ...