Browsing by Subject "DRUG DISCOVERY"

Now showing items 1-4 of 4

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      Combining rimonabant and fentanyl in a single entity: preparation and pharmacological results 

      Fernández Fernández, Cristina; Callado Hernando, Luis Felipe ORCID; Girón, Rocío; Sánchez, Eva; Erdozain Fernández, Amaia Maite ORCID; López-Moreno, José Antonio; Morales, Paula; Rodríguez de Fonseca, Fernando; Fernández-Ruiz, Javier; Goya, Pilar; Meana Martínez, José Javier ORCID; Martín, Isabel; Jagerovic, Nadine (Dove Medical Press, 2014)
      Based on numerous pharmacological studies that have revealed an interaction between cannabinoid and opioid systems at the molecular, neurochemical, and behavioral levels, a new series of hybrid molecules has been prepared ...
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      Development of nucleic acid vaccines: use of self-amplifying RNA in lipid nanoparticles 

      Rodríguez Gascón, Alicia; Del Pozo Rodríguez, Ana ORCID; Solinís Aspiazu, María Ángeles ORCID (Dove Medical Press, 2014)
      Self-amplifying RNA or RNA replicon is a form of nucleic acid-based vaccine derived from either positive-strand or negative-strand RNA viruses. The gene sequences encoding structural proteins in these RNA viruses are ...
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      Increased antiparkinson efficacy of the combined administration of VEGF- and GDNF-loaded nanospheres in a partial lesion model of Parkinson's disease 

      Herrán Martínez, Enara; Requejo Rodríguez, Catalina ORCID; Ruiz Ortega, José Ángel; Aristieta Arbelaiz, Asier; Igartua Olaechea, Manuela ORCID; Bengoetxea Odriozola, Harkaitz; Ugedo Urruela, Luisa; Pedraz Muñoz, José Luis ORCID; Lafuente Sánchez, José Vicente ORCID; Hernández Martín, Rosa María ORCID (Dove Medical Press, 2014)
      Current research efforts are focused on the application of growth factors, such as glial cell line-derived neurotrophic factor (GDNF) and vascular endothelial growth factor (VEGF), as neuroregenerative approaches that will ...
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      Mugilid Fish Are Sentinels of Exposure to Endocrine Disrupting Compounds in Coastal and Estuarine Environments 

      Ortiz Zarragoitia, Maren; Bizarro Villán, Cristina; Rojo Bartolomé, Iratxe ORCID; Diaz de Cerio Arruabarrena, Oihane ORCID; Cajaraville Bereciartua, Miren Pilare ORCID; Cancio Uriarte, Ibon (MDPI, 2014-09-12)
      Effects on fish reproduction can result from a variety of toxicity mechanisms first operating at the molecular level. Notably, the presence in the environment of some compounds termed endocrine disrupting chemicals (EDCs) ...