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The 2018 biomembrane curvature and remodeling roadmap
(IOP Publishing, 2018-08-30)
The importance of curvature as a structural feature of biological membranes has been recognized for many years and has fascinated scientists from a wide range of different backgrounds. On the one hand, changes in membrane ...
Selective Interaction of Syntaxin 1A with KCNQ2: Possible Implications for Specific Modulation of Presynaptic Activity
Regev, Noa; Degani-Katzav, Nurit; Korngreen, Alon; Etzioni, Adi; Siloni, Sivan; Alaimo Campi, Alessandro 
; Chikvashvili, Dodo; Villarroel Muñoz, Álvaro; Attali, Bernard; Lotan, Ilana (Public Library Science,, 2009-08-13)
; Chikvashvili, Dodo; Villarroel Muñoz, Álvaro; Attali, Bernard; Lotan, Ilana (Public Library Science,, 2009-08-13)
KCNQ2/KCNQ3 channels are the molecular correlates of the neuronal M-channels, which play a major role in the control of neuronal excitability. Notably, they differ from homomeric KCNQ2 channels in their distribution pattern ...
Highlights of the 2nd International Symposium on Tribbles and Diseases: Tribbles Tremble in Therapeutics for Immunity, Metabolism, Fundamental Cell Biology and Cancer
Cui, Bing; Eyers, Patrick A.; Dobens, Leonard L.; Tan, Nguan Soon; Mace, Peter D.; Link, Wolfgang A.; Kiss Toth, Endre; Keeshan, Karen; Nakamura, Takuro; Pear, Warren S.; Feseha, Yodit; Johnston, Jessica; Carracedo Pérez, Arkaitz ; Scheideler, Marcel; llyas, Zabran; Bauer, Robert C.; Erusalimsky, Jorge D.; Grzesik, Dominika; Salamanca Viloria, Juan; Lv, Xiaoxi; Jin, Yishi; Li, Ke; Velasco, Guillermo; Shang, Shuang; Lizcano de Vega, José Miguel; Zhang, Xiaowei; Zhou, Jichao; Yu, Jiaojiao; Hua, Fang; Wang, Feng; Liu, Shanshan; Yu, Jinmei; Hu, Zhuowei (Institute of Materia Medica, 2019-03)
; Scheideler, Marcel; llyas, Zabran; Bauer, Robert C.; Erusalimsky, Jorge D.; Grzesik, Dominika; Salamanca Viloria, Juan; Lv, Xiaoxi; Jin, Yishi; Li, Ke; Velasco, Guillermo; Shang, Shuang; Lizcano de Vega, José Miguel; Zhang, Xiaowei; Zhou, Jichao; Yu, Jiaojiao; Hua, Fang; Wang, Feng; Liu, Shanshan; Yu, Jinmei; Hu, Zhuowei (Institute of Materia Medica, 2019-03)
The Tribbles (TRIB) family of pseudokinase proteins has been shown to play key roles in cell cycle, metabolic diseases, chronic inflammatory disease, and cancer development. A better understanding of the mechanisms of TRIB ...
Application of Solid Lipid Nanoparticles to Improve the Efficiency of Anticancer Drugs
Bayón Cordero, Laura; ; Arana Urbieta, Lide (MDPI, 2019-03-22)
(MDPI, 2019-03-22)
Drug delivery systems have opened new avenues to improve the therapeutic effects of already-efficient molecules. Particularly, Solid Lipid Nanoparticles (SLNs) have emerged as promising nanocarriers in cancer therapy. SLNs ...
Solid Lipid Nanoparticles Surface Modification Modulates Cell Internalization and Improves Chemotoxic Treatment in an Oral Carcinoma Cell Line
Arana Urbieta, Lide ; Bayón Cordero, Laura; Sarasola Telleria, Laura Isabel; Berasategi, Miren; Ruiz, Sandra; (MDPI, 2019-03-20)
; Bayón Cordero, Laura; Sarasola Telleria, Laura Isabel; Berasategi, Miren; Ruiz, Sandra; (MDPI, 2019-03-20)
Solid lipid nanoparticles (SLN) present low toxicity, versatility to incorporate both lipophilic and hydrophilic drugs, controlled drug release and they are easy to scale-up. It is well known that the endocytosis pathway ...
In-Depth Proteomic Characterization of Classical and Non-Classical Monocyte Subsets
Segura, Victor; Valero, M. Luz; Cantero, Laura; Muñoz, Javier; Zarzuela, Eduardo; García, Fernando; Aloria Escolastico, Kerman; Beaskoetxea Lejarzegi, Javier; Arizmendi Bastarrika, Jesús María ; Navajas, Rosana; Paradela, Alberto; Díez, Paula; Degano, Rosa M.; Fuentes, Manuel; Orfao, Alberto; García Montero, Andrés; Garin-Muga, Alba; Corrales, Fernando J.; Sánchez del Pino, Manuel M. (MDPI, 2018-02-05)
; Navajas, Rosana; Paradela, Alberto; Díez, Paula; Degano, Rosa M.; Fuentes, Manuel; Orfao, Alberto; García Montero, Andrés; Garin-Muga, Alba; Corrales, Fernando J.; Sánchez del Pino, Manuel M. (MDPI, 2018-02-05)
Monocytes are bone marrow-derived leukocytes that are part of the innate immune system. Monocytes are divided into three subsets: classical, intermediate and non-classical, which can be differentiated by their expression ...
Folding Status Is Determinant over Traffic-Competence in Defining CFTR Interactors in the Endoplasmic Reticulum
(MDPI, 2019-04-14)
The most common cystic fibrosis-causing mutation (F508del, present in ~85% of CF patients) leads to CFTR misfolding, which is recognized by the endoplasmic reticulum (ER) quality control (ERQC), resulting in ER retention ...
Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA
(Nature Publishing, 2016-03)
The biosynthesis of phospholipids and glycolipids are critical pathways for virtually all cell membranes. PatA is an essential membrane associated acyltransferase involved in the biosynthesis of mycobacterial phosphatidy ...
Creating stable Floquet–Weyl semimetals by laser-driving of 3D Dirac materials
(Nature Publishing, 2017-01-17)
Tuning and stabilizing topological states, such as Weyl semimetals, Dirac semimetals or topological insulators, is emerging as one of the major topics in materials science. Periodic driving of many-body systems offers a ...
Structural remodeling and oligomerization of human cathelicidin on membranes suggest fibril-like structures as active species
(Nature Publishing, 2017-11-13)
Antimicrobial peptides as part of the mammalian innate immune system target and remove major bacterial pathogens, often through irreversible damage of their cellular membranes. To explore the mechanism by which the important ...