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GFAP Isoforms in Adult Mouse Brain with a Focus on Neurogenic Astrocytes and Reactive Astrogliosis in Mouse Models of Alzheimer Disease
(Public Library of Science, 2012-08-13)
Glial fibrillary acidic protein (GFAP) is the main astrocytic intermediate filament (IF). GFAP splice isoforms show differential expression patterns in the human brain. GFAPδ is preferentially expressed by neurogenic ...
GmcA Is a Putative Glucose-Methanol-Choline Oxidoreductase Required for the Induction of Asexual Development in Aspergillus nidulans
Echeveste Juárez, Oier 
; ; ; ; ; ; ; (Public Library of Science, 2012-07-05)
; ; ; ; ; ; ; (Public Library of Science, 2012-07-05)
Aspergillus nidulans asexual differentiation is induced by Upstream Developmental Activators (UDAs) that include the bZIP-type Transcription Factor (TF) FlbB. A 2D-PAGE/MS-MS-coupled screen for proteins differentially ...
Ancient DNA from Hunter-Gatherer and Farmer Groups from Northern Spain Supports a Random Dispersion Model for the Neolithic Expansion into Europe
Hervella Afonso, Montserrat ; Izagirre Arribalzaga, Neskuts ; Alonso Alegre, Santos ; ; ; ; De la Rúa Vaca, Concepción (Public Library of Science, 2012-04-25)
; Izagirre Arribalzaga, Neskuts ; Alonso Alegre, Santos ; ; ; ; De la Rúa Vaca, Concepción (Public Library of Science, 2012-04-25)
Background/Principal Findings: The phenomenon of Neolithisation refers to the transition of prehistoric populations from a hunter-gatherer to an agro-pastoralist lifestyle. Traditionally, the spread of an agro-pastoralist ...
The Role of the Subthalamic Nucleus in L-DOPA Induced Dyskinesia in 6-Hydroxydopamine Lesioned Rats
; Azkona Mendoza, Garikoitz ; Sagarduy Crespo, Ainhoa ; ; ; ; (Public Library of Science, 2012-08-06)
; Sagarduy Crespo, Ainhoa ; ; ; ; (Public Library of Science, 2012-08-06)
L-DOPA is the most effective treatment for Parkinson's disease (PD), but prolonged use leads to disabling motor complications including dyskinesia. Strong evidence supports a role of the subthalamic nucleus (STN) in the ...
Early Functional Deficit and Microglial Disturbances in a Mouse Model of Amyotrophic Lateral Sclerosis
(Public Library of Science, 2012-04-25)
Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by selective motoneurons degeneration. There is today no clear-cut pathogenesis sequence nor any treatment. However growing ...
Kv7 Channels Can Function without Constitutive Calmodulin Tethering
; ; ; Alaimo Campi, Alessandro ; ; ; Zamalloa Echevarría, Teresa ; ; ; ; Casis Sáenz, Oscar ; (Public Library of Science, 2011-09-28)
; ; ; Zamalloa Echevarría, Teresa ; ; ; ; Casis Sáenz, Oscar ; (Public Library of Science, 2011-09-28)
M-channels are voltage-gated potassium channels composed of Kv7.2-7.5 subunits that serve as important regulators of neuronal excitability. Calmodulin binding is required for Kv7 channel function and mutations in Kv7.2 ...
Uncovering Ecosystem Service Bundles through Social Preferences
(Public Library of Science, 2012-06-18)
Ecosystem service assessments have increasingly been used to support environmental management policies, mainly based on biophysical and economic indicators. However, few studies have coped with the social-cultural dimension ...
Viability Conditions for a Compartmentalized Protometabolic System: A Semi-Empirical Approach
(Public Library Science, 2012-06)
In this work we attempt to find out the extent to which realistic prebiotic compartments, such as fatty acid vesicles, would constrain the chemical network dynamics that could have sustained a minimal form of metabolism. ...
Ca2+ Influx and Tyrosine Kinases Trigger Bordetella Adenylate Cyclase Toxin (ACT) Endocytosis. Cell Physiology and Expression of the CD11b/CD18 Integrin Major Determinants of the Entry Route
; ; ; González Bullón, David ; ; (Public Library Publishing, 2013-09)
; ; (Public Library Publishing, 2013-09)
Humans infected with Bordetella pertussis, the whooping cough bacterium, show evidences of impaired host defenses. This pathogenic bacterium produces a unique adenylate cyclase toxin (ACT) which enters human phagocytes and ...
The Influence of the Val158Met Catechol-O-Methyltransferase Polymorphism on the Personality Traits of Bipolar Patients
; ; ; ; ; ; González Torres, Miguel Ángel ; (Public Library of Science, 2013-04-30)
; (Public Library of Science, 2013-04-30)
Introduction: Certain personality traits and genetic polymorphisms are contributing factors to bipolar disorder and its symptomatology, and in turn, this syndrome influences personality. The aim of the present study is to ...