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Selective Interaction of Syntaxin 1A with KCNQ2: Possible Implications for Specific Modulation of Presynaptic Activity
(Public Library Science,, 2009-08-13)
KCNQ2/KCNQ3 channels are the molecular correlates of the neuronal M-channels, which play a major role in the control of neuronal excitability. Notably, they differ from homomeric KCNQ2 channels in their distribution pattern ...
Glycosaminoglycans in human retinoblastoma cells: heparan sulfate, a modulator of the pigment epithelium-derived factor-receptor interactions
(BioMed Central, 2003-02-19)
BACKGROUND: Pigment epithelium-derived factor (PEDF) has binding affinity for cell-surface receptors in retinoblastoma cells and for glycosaminoglycans. We investigated the effects of glycosaminoglycans on PEDF-receptor ...
A Computational Analysis of Protein-Protein Interaction Networks in Neurodegenerative Diseases
(Biomed Central, 2008-06-20)
Background: Recent developments have meant that network theory is making an important contribution to the topological study of biological networks, such as protein-protein interaction (PPI) networks. The identification of ...
Teoría de las tres dimensiones del Desarrollo Sostenible
(Asociación Española de Ecología Terrestre, 2001-12)
Actualmente existen múltiples interpretaciones del concepto de desarrollo sostenible, y muchas de ellas coinciden en que para lograrlo, las medidas a poner en marcha deberán ser económicamente viables, respetar el medio ...
Three-dimensional growth as multicellular spheroid activates the proangiogenic phenotype of colorectal carcinoma cells via LFA-1-dependent VEGF: implications on hepatic micrometastasis
(BioMed Central, 2008-10)
Background: The recruitment of vascular stromal and endothelial cells is an early event occurring during cancer cell growth at premetastatic niches, but how the microenvironment created by the initial three-dimensional ...
Phosphorylation of the carboxy-terminal domain of histone H1: effects on secondary structure and DNA condensation
(Oxford University Press, 2008-08)
Linker histone H1 plays an important role in chromatin folding. Phosphorylation by cyclin-dependent kinases is the main post-translational modification of histone H1. We studied the effects of phosphorylation on the secondary ...
Quince años de investigaciones histórico-arqueológicas en torno a Getaria
(Sociedad de Ciencias Aranzadi, 2005)
[ES] Se procede a realizar una revisión crítica de las principales aportaciones histórico-arqueológicas a la historia antigua y medieval del casco histórico de Getaria y su entrono realizadas durante los últimos quince años.
Euskarazko irakaskuntza Goierrin XVIII. mendeko bigarren erdian
(IKER UMR 5478, 2004)
[EUS] Artikulu honetan XVIII. mendean Gipuzkoako Goierrin ezarritako irakaskuntza elebidunari buruzko sakonketa egiten da. Non, noiz, nola, nork eta zergatik.
Conflictos entre el Corregidor y la Provincia de Guipúzcoa por la jurisdicción sobre los bosques durante el siglo XVIII: lo excepcional del caso guipuzcoano
(Sociedad de Estudios Vascos, Eusko Ikaskuntza, 2001)
[ES]Si hasta mediados del siglo XVIII la jurisdicción sobre los bosques guipuzcoanos fue acumulativa y a prevención entre las instituciones provinciales, los alcaldes, el Corregidor y las instituciones de Marina, la Real ...
A Self-Referencing Intensity Based Polymer Optical Fiber Sensor for Liquid Detection
(MDPI, 2009-08)
A novel self-referencing fiber optic intensity sensor based on bending losses of a partially polished polymer optical fiber (POF) coupler is presented. The coupling ratio (K) depends on the external liquid in which the ...