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AIE-featured tetraphenylethylene nanoarchitectures in biomedical application: Bioimaging, drug delivery and disease treatment
(Elsevier, 2021-11-15)
[EN]The development of aggregation-induced emission (AIE) has received extreme considerations from basic and clinical researches. To date, various luminogens with AIE property (AIEgens) have been broadly utilized in ...
Distributional impact of COVID-19: regional inequalities in cases and deaths in Spain during the first wave
(Taylor & Francis, 2021-07-03)
Spain is being hit hard by the COVID-19 pandemic. During the first wave, from mid-March to early June 2020, the disease caused nearly 30,000 deaths in a population of 47 million. This article quantifies the unevenness in ...
GSE4-Loaded Nanoparticles a Potential Therapy for Lung Fibrosis that Enhances Pneumocyte Growth, Reduces Apoptosis and DNA Damage
(Wiley, 2021-03)
Idiopathic pulmonary fibrosis is a lethal lung fibrotic disease, associated with aging with a mean survival of 2-5 years and no curative treatment. The GSE4 peptide is able to rescue cells from senescence, DNA and oxidative ...
Nanostructured Lipid Carriers for Delivery of Chemotherapeutics: A Review
(MDPI, 2020-03-23)
The efficacy of current standard chemotherapy is suboptimal due to the poor solubility and short half-lives of chemotherapeutic agents, as well as their high toxicity and lack of specificity which may result in severe side ...
Measurement of Corporate Social Responsibility: A Review of Corporate Sustainability Indexes, Rankings and Ratings
(MDPI, 2020-03-10)
Companies are currently changing their traditional role in society and transforming it into a proactive role in which their operations generate social and environmental positive impacts. Corporate Social Responsibility ...
iPSC-Derived Intestinal Organoids from Cystic Fibrosis Patients Acquire CFTR Activity upon TALEN-Mediated Repair of the p.F508del Mutation
(Cell Press, 2020-06-12)
Cystic fibrosis (CF) is the main genetic cause of death among the Caucasian population. The disease is characterized by abnormal fluid and electrolyte mobility across secretory epithelia. The first manifestations occur ...
The mito-QC Reporter for Quantitative Mitophagy Assessment in Primary Retinal Ganglion Cells and Experimental Glaucoma Models
(MDPI, 2020-03-10)
Mitochondrial damage plays a prominent role in glaucoma. The only way cells can degrade whole mitochondria is via autophagy, in a process called mitophagy. Thus, studying mitophagy in the context of glaucoma is essential ...
The Noradrenergic System in Parkinson’s Disease
(Frontiers Media, 2020-04-08)
Nowadays it is well accepted that in Parkinson's disease (PD), the neurodegenerative process occurs in stages and that damage to other areas precedes the neuronal loss in the substantia nigra pars compacta, which is ...
Study of the Environmental Implications of Using Metal Powder in Additive Manufacturing and Its Handling
(MDPI, 2020-02-17)
Additive Manufacturing, AM, is considered to be environmentally friendly when compared to conventional manufacturing processes. Most researchers focus on resource consumption when performing the corresponding Life Cycle ...
Locus coeruleus norepinephrine activity mediates sensory-evoked awakenings from sleep
(American Association for the Advancement of Science, 2020-04-08)
A defining feature of sleep is reduced responsiveness to external stimuli, but the mechanisms mediating sensory-evoked arousal remain unclear. We hypothesized that reduced locus coeruleus (LC) norepinephrine (NE) activity ...