BackBrowsing BCBL-Publications by Author "Fisher, Simon E."
Now showing items 1-5 of 5
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Discovery of 42 genome-wide significant loci associated with dyslexia
(SPRINGER NATURE, 2022)Reading and writing are crucial life skills but roughly one in ten children are affected by dyslexia, which can persist into adulthood. Family studies of dyslexia suggest heritability up to 70%, yet few convincing genetic ... -
Genome-wide analyses of individual differences in quantitatively assessed reading- and language-related skills in up to 34,000 people
(PNAS, 2022)The use of spoken and written language is a fundamental human capacity. Individual differences in reading- and language-related skills are influenced by genetic variation, with twin-based heritability estimates of 30 to ... -
Handedness and its genetic influences are associated with structural asymmetries of the cerebral cortex in 31,864 individuals
(Proceedings of the National Academy of Sciences of the United States of America, 2021)Roughly 10% of the human population is left-handed, and this rate is increased in some brain-related disorders. The neuroanatomical correlates of hand preference have remained equivocal. We resampled structural brain ... -
Hypothesis-driven genome-wide association studies provide novel insights into genetics of reading disabilities
(SPRINGER, 2022)Reading Disability (RD) is often characterized by difficulties in the phonology of the language. While the molecular mechanisms underlying it are largely undetermined, loci are being revealed by genome-wide association ... -
Whole‑genome sequencing identifies functional noncoding variation in SEMA3C that cosegregates with dyslexia in a multigenerational family
(Human Genetics, 2021)Dyslexia is a common heritable developmental disorder involving impaired reading abilities. Its genetic underpinnings are thought to be complex and heterogeneous, involving common and rare genetic variation. Multigenerational ...