Pyrrolidin-2,3-diones as pronucleophiles in organocatalytic Michael additions to vinyl sulfones

Abstract

[EN]This research project has been developed at the Department of Organic Chemistry I at the Faculty of Chemistry in San Sebastian under the guidance of professor Antonia Mielgo from the same department. The research work of this project is a continuation of previous work from the research group on the potential of pyrrolidin-2,3-diones as pronucleophiles in asymmetric organocatalysis. More specifically, in this case the goal has been the investigation of the Michael reaction of C4-substituted pyrrolidin-2,3-diones with vinyl sulfones in the presence of chiral Brønsted bases as catalysts.

[EU]Ikerketa lan hau Kimika Fakultateko Kimika Organikoa I sailean garatu da, Donostin, Antonia Mielgo irakaslearen zuzendaritzapean. Proiektua ikerketa taldean garatzen ari zen pirrolidin-2,3-dionek organokatalisi asimetrikoan pronukleofilo moduan duten potentzialari buruzko lanaren jarraipena da. Zehazki, helburua binil sulfonetara C4-n ordezkatutako pirrolidin-2,3-dionen Michael adizioa ikertzea izan da, Brønsted base kiralen presentzian katalizatzaile moduan.