Browsing Artículos by Author "Echeazarra, Leyre"
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Adult and Developing Zebrafish as Suitable Models for Cardiac Electrophysiology and Pathology in Research and Industry
Echeazarra Escudero, Leire; Hortigón Vinagre, María Pura; Casis Sáenz, Oscar ; Gallego Muñoz, Mónica (Frontiers Media, 2021-01-13)The electrophysiological behavior of the zebrafish heart is very similar to that of the human heart. In fact, most of the genes that codify the channels and regulatory proteins required for human cardiac function have their ... -
Banpirismoaren mitoa zientziaren argitan
Echeazarra, Leyre (Elhuyar, 2023-12-01)Ezaguna denez, mitoak jendeak mundua azaltzeko asmatu dituen istorioak dira. Banpirismoaren mitoa gizateria bezain zaharra da. Antzinatik XVIII. mendera arte, banpiroak izaki izugarri gaiztotzat hartzen ziren, eta beldur ... -
Biluzik elurretan.
Echeazarra, Leyre (Elhuyar, 2021-07-21)2021. urte hau historikoa izaten ari da, ez bakarrik COVID-19aren pandemiagatik eta AEBko Kapitolioari eraso egin ziotelako, baita Filomena deituriko ekaitz gogorrak eragindako muturreko hotz-boladagatik ere. Zer pentsatuko ... -
CaMKII modulates the cardiac transient outward K+ current through their association in non-caveolar membrane rafts
Alday, Aintzane; Ahyayauch, Hasna; Fernández López, Victor; Echeazarra Escudero, Leire; Urrutia Iñiguez, Janire; Casis Sáenz, Oscar ; Gallego Muñoz, Mónica (University of Duisburg-Essen, 2020-01-15)Background/aims: To test whether the physiological regulation of the cardiac Kv4 channels by the Ca2+/calmodulin-dependent protein kinase II (CaMKII) is restricted to lipid rafts and whether the interactions observed in ... -
Cellular neurochemical characterization and subcellular localization of Phospholipase C-β1 in rat brain
Montaña, Mario; García del Caño, Gontzal; López de Jesús, Maider ; González Burguera, Imanol; Echeazarra, Leyre; Barrondo Lacarra, Sergio ; Sallés Alvira, Joan (Elsevier, 2012-10-11)The present study describes a complete and detailed neuroanatomical distribution map of the phospholipase C beta1 (PLCβ1) isoform along the adult rat neuraxis, and defines the phenotype of cells expressing PLCβ1, along ... -
Chatbot-erabilera ahozko konpetentzia lantzeko unibertsitateko Zientzia-ikasleen artean: M-Learning-etako aplikazio praktikoa
Echeazarra, Leyre (Facultad de Educación de Bilbao. Universidad del País Vasco (UPV/EHU), 2018-06-30)Informazioaren eta Komunikazioaren Teknologien (IKT) erabilera asko handitu da XX. mendeko azken hamarkadatik gaur arte. IKT-en iraultza honek inpaktu handia izan du gure bizitzaren alderdi guztietan, baita ikaskuntza-irakaskuntza ... -
Deciphering the roles of triiodothyronine (T3) and thyroid stimulating hormone (TSH) on cardiac electrical remodeling in clinical and experimental hypothyroidism
Casis Sáenz, Oscar ; Echeazarra, Leyre; Sáenz Díez, Beatriz; Gallego Muñoz, Mónica (Springer, 2024-02)Hypothyroidism is the most frequent endocrine pathology. Although clinical or overt hypothyroidism has been traditionally associated to low T3 / T4 and high thyrotropin (TSH) circulating levels, other forms exist such as ... -
Design and validation of recombinant protein standards for quantitative Western blot analysis of cannabinoid CB1 receptor density in cell membranes: an alternative to radioligand binding methods
Saumell Esnaola, Miquel; Elejaga Jimeno, Ainhoa; Echeazarra Escudero, Leire; Borrega Román, Leire; Barrondo Lacarra, Sergio ; López de Jesús, Maider ; González Burguera, Imanol; Gomez-Caballero, Alberto; Goicolea Altuna, María Aranzazu ; Sallés Alvira, Joan; García del Caño, Gontzal (BMC, 2022)Background: Replacement of radioligand binding assays with antibody-antigen interaction-based approaches for quantitative analysis of G protein-coupled receptor (GPCR) levels requires the use of purified protein standards ... -
Fit-for-purpose based testing and validation of antibodies to amino- and carboxy-terminal domains of cannabinoid receptor 1
Echeazarra Escudero, Leire; García del Caño, Gontzal; Barrondo Lacarra, Sergio ; González Burguera, Imanol; Saumell Esnaola, Miquel; Aretxabala Rodríguez, Xabier; López de Jesús, Maider ; Borrega Román, Leire; Mato Santos, Susana ; Ledent, Catherine; Matute Almau, Carlos José; Goicolea Altuna, María Aranzazu ; Sallés Alvira, Joan (Springer, 2021-11)Specific and selective anti-CB1 antibodies are among the most powerful research tools to unravel the complex biological processes mediated by the CB1 receptor in both physiological and pathological conditions. However, low ... -
High Thyrotropin Is Critical for Cardiac Electrical Remodeling and Arrhythmia Vulnerability in Hypothyroidism
Fernández Ruocco, Julieta; Gallego Muñoz, Mónica ; Rodríguez de Yurre, Ainhoa; Zayas Arrabal, Julián; Echeazarra Escudero, Leire; Alquiza Etxabe, Amaia; Fernández López, Víctor; Rodríguez Robledo, Juan Manuel; Brito, Oscar; Schleier, Ygor; Sepúlveda, Marisa; Oshiyama, Natalia F.; Vila Petroff, Martin; Bassani, Rosana A.; Medei, Emiliano; Casis Sáenz, Oscar (Mary Ann Liebert, 2019-07-17)Background: Hypothyroidism, the most common endocrine disease, induces cardiac electrical remodeling that creates a substrate for ventricular arrhythmias. Recent studies report that high thyrotropin (TSH) levels are related ... -
Ispilu bizidunak gara: Ispilu-neuronek besteen larruan jartzen gaituzte
Echeazarra Escudero, Leire (Elhuyar, 2010-06)Imajinatu zirko-ikuskizun bat ikusten ari zarela. Bat-batean, trapezioan dagoen akrobata irristatu egiten da eta oreka galtzen du… bihotza uzkurtu egin zaizu! Eztarrian korapilo bat duzu eta taupadak bizkortu egin zaizkizu. ... -
Kv1.3 Channel Blockade Improves Inflammatory Profile, Reduces Cardiac Electrical Remodeling, and Prevents Arrhythmia in Type 2 Diabetic Rats
Zayas Arrabal, Julián; Alquiza Etxabe, Amaia; Rodríguez de Yurre, Ainhoa; Echeazarra Escudero, Leire; Fernández López, Víctor; Gallego Muñoz, Mónica ; Casis Sáenz, Oscar (Springer, 2023-02)Purpose Kv1.3 channel regulates the activity of lymphocytes, macrophages, or adipose tissue and its blockade reduces inflammatory cytokine secretion and improves insulin sensitivity in animals with metabolic syndrome and ... -
Metformin Reduces Potassium Currents and Prolongs Repolarization in Non-Diabetic Heart
Malagueta Vieira, Layse; Fernández Ruocco, Julieta; Hortigon-Vinagre, Maria Pura ; Zamora, Víctor; Zayas Arrabal, Julián; Echeazarra Escudero, Leire; Smith, Godfrey; Vila Petroff, Martín; Medei, Emiliano; Casis Sáenz, Oscar ; Gallego Muñoz, Mónica (MDPI, 2022-05-27)Metformin is the first choice drug for the treatment of type 2 diabetes due to positive results in reducing hyperglycaemia and insulin resistance. However, diabetic patients have higher risk of ventricular arrhythmia and ... -
Neuromarketina: kontsumitzaileon garunaren barruan
Echeazarra, Leyre (Elhuyar, 2012-05-01)Zer nahiago duzu? Pepsi ala Coca-Cola? McDonald´s ala Burger King? Apple ala Microsoft? Mercedes ala Golf? Pentsatu al duzu inoiz norberaren gogoak eta nahiak zertan oinarrituta dauden? Zerk bultzatzen gaitu hori erostera? ... -
Plastikotasun neuronala: garunaren zaindari
Echeazarra, Leyre (Elhuyar, 2011-04-01)Denbora luzez pentsatu da garuneko lesio baten ondorioz neuronak betirako galtzen zirela eta, heldutasunera behin helduta, burmuinaren garapena eten egiten zela. Azken hamarkadetan, berriz, argi geratu da garunak malgutasuna ... -
Plazeraren oinarri neurobiologikoak: sari-sistema zerebrala
Echeazarra, Leyre (Elhuyar, 2013-07-01)Sari-sistema edo bide mesokortikolinbiko dopaminergiko deritzana plazerarekin erlazionatuta dagoen sare neuronal bat da.Sistema horren aurkikuntza oso garrantzitsua izan da neurozientzia eta psikologia arloan. Lehen ... -
Student-generated online videos to develop cross-curricular and curricular competencies in Nursing Studies.
Pereira Varela, Juan Antonio ; Echeazarra Escudero, Leire; Sanz-Santamaría, Silvia; Gutiérrez Serrano, Julián (Elsevier, 2013-07-06)In response to the necessity of implementing innovative strategies and new teaching methodologies for the design of University degrees curricula according to the new educational model put forward by the European Space of ... -
TensioBot: a chatbot assistant for self-managed in-house blood pressure checking
Echeazarra Escudero, Leire; Pereira Varela, Juan Antonio ; Saracho Rotaeche, Ramón (Springer, 2021-03-15)[ES] Tensiobot es un chatbot de apoyo asistencial, cuyo objetivo esayudar a los pacientes a realizar sus mediciones de tensión arterial en domicilio. Nuestros resultados muestran que el cumplimiento del programa de control ... -
Up-regulation of CB1 Cannabinoid Receptors Located at Glutamatergic Terminals in the Medial Prefrontal Cortex of the Obese Zucker Rat.
Echeazarra, Leyre; Barrondo Lacarra, Sergio ; García del Caño, Gontzal; Bonilla del Río, Itziar; Egaña Huguet, Jon; Puente Bustinza, Nagore ; Aretxabala Rodríguez, Xabier; Montaña, Mario; López de Jesús, Maider ; González Burguera, Imanol; Saumell Esnaola, Miquel; Goicolea Altuna, María Aranzazu ; Grandes Moreno, Pedro Rolando ; Sallés Alvira, Joan (Frontiers Media, 2022-10-18)The present study describes a detailed neuroanatomical distribution map of the cannabinoid type 1 (CB1) receptor, along with the biochemical characterization of the expression and functional coupling to their cognate G i/o ... -
Validation of an LC-ESI-MS/MS for the quantitation of phosphodiesterase-5 inhibitors and their main metabolites in rat serum and brain tissue samples.
Unceta Zaballa, Nora ; Echeazarra Escudero, Leire; Montaña, Mario; Sallés Alvira, Joan; Gómez Caballero, Alberto; Goicolea Altuna, María Aranzazu ; Barrio Díez-Caballero, Ramón José (Elsevier, 2012-105-1)This work proposes a liquid chromatography-electrospray ionization ion trap mass spectrometry (LC-ESI-ITMS) method, for the quantification of sildenafil (SDF), tadalafil (TDF) and vardenafil (VDF) and their metabolites ...