Examinar Artículos por departamento (eus.) "Kimika organikoa I"
Now showing items 21-40 of 151
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Asymmetric Synthesis of Tailor-Made Amino Acids Using Chiral Ni(II) Complexes of Schiff Bases. An Update of the Recent Literature
(MDPI, 2020-06-12)Tailor-made amino acids are indispensable structural components of modern medicinal chemistry and drug design. Consequently, stereo-controlled preparation of amino acids is the area of high research activity. Over last ... -
Asymmetric Synthesis of Tetrasubstituted α-Aminophosphonic Acid Derivatives
(MDPI, 2021-05-27)Due to their structural similarity with natural α-amino acids, α-aminophosphonic acid derivatives are known biologically active molecules. In view of the relevance of tetrasubstituted carbons in nature and medicine and the ... -
Ba+2 ion trapping using organic submonolayer for ultra-low background neutrinoless double beta detector
(Nature, 2022-12)If neutrinos are their own antiparticles the otherwise-forbidden nuclear reaction known as neutrinoless double beta decay can occur. The very long lifetime expected for these exceptional events makes its detection a daunting ... -
Beta-Hydroxyimino Phosphorus Derivatives. An Efficient Tool in Organic Synthesis
(Bentham Science Publishers, 2011)[EN] The purpose of this review article is to illustrate synthetic aspects of functionalized phosphorus derivatives containing an oximo moiety at the beta-position. First section will be focused on the synthesis of phosphine ... -
Bicolour fluorescent molecular sensor for cations: design and experimental validation
(Royal Society of Chemistry, 2021-07-02)Molecular entities whose fluorescence spectra are different when they bind metal cations are termed bicolour fluorescent molecular sensors. The basic design criteria of this kind of compound are presented and the different ... -
Biological Evaluation of Both Enantiomers of Fluoro-Thalidomide Using Human Myeloma Cell Line H929 and Others
(Public Library Science, 2017-08-01)Over the last few years, thalidomide has become one of the most important anti-tumour drugs for the treatment of relapsed-refractory multiple myeloma. However, besides its undesirable teratogenic side effect, its configurational ... -
Boosting background suppression in the NEXT experiment through Richardson-Lucy deconvolution
(Springer, 2021-07-21)Next-generation neutrinoless double beta decay experiments aim for half-life sensitivities of similar to 10(27) yr, requiring suppressing backgrounds to < 1 count/tonne/yr. For this, any extra background rejection handle, ... -
Brønsted Base Catalyzed One-Pot Synthesis od Stereodefined Six-Member Carbocycles Featuring Transient Trienolates and a Key Intramolecular 1,6-Addition
(Wiley-VCH, 2019-07-31)Acatalyst-driven one-pot reaction sequence is developed for the enantio- and diastereoselective synthesis of tetrasubstituted cyclohexenes from simple unsaturated ketones or thioesters.The method involves atertiary ... -
Brønsted Base-Catalyzed Enantioselective α-Functionalization of Carbonyl Compounds Involving π-Extended Enolates
(Wiley, 2023-11)Chiral Brønsted base (BB) catalyzed asymmetric transformations constitute an important tool for synthesis. A meaningful fraction of these transformations proceeds through transiently generated enolate intermediates, which ... -
Catalysis of a 1,3-dipolar reaction by distorted DNA incorporating a heterobimetallic platinum(II) and copper(II) complex
(Royal Society of Chemistry, 2017-08-11)A novel catalytic system based on covalently modified DNA is described. This catalyst promotes 1,3-dipolar reactions between azomethine ylides and maleimides. The catalytic system is based on the distortion of the double ... -
Catalytic Asymmetric α-Functionalization of α-Branched Aldehydes
(MDPI, 2023-03-16)Aldehydes constitute a main class of organic compounds widely applied in synthesis. As such, catalyst-controlled enantioselective α-functionalization of aldehydes has attracted great interest over the years. In this context, ... -
Catalytic Enantioselective Synthesis of Tertiary Thiols From 5H-Thiazol-4-ones and Nitroolefins: Bifunctional Ureidopeptide-Based Brønsted Base Catalysis
(WILEY-VCH Verlag, 2013-09-17)The direct catalytic reaction between an enolizable carbonyl compound and an electrophile under proton-transfer conditions has emerged as a challenging versatile transformation in organic synthesis.1 Over the last years ... -
Characterization of the Antitumor Potential of Extracts of Cannabis sativa Strains with High CBD Content in Human Neuroblastoma
(MDPI, 2023-02-14)Cannabis has been used for decades as a palliative therapy in the treatment of cancer. This is because of its beneficial effects on the pain and nausea that patients can experience as a result of chemo/radiotherapy. ... -
Chiral gold(I) vs chiral silver complexes as catalysts for the enantioselective synthesis of the second generation GSK-hepatitis C virus inhibitor
(Beilstein Institut, 2011-07)The synthesis of a GSK 2(nd) generation inhibitor of the hepatitis C virus, by enantioselective 1,3-dipolar cycloaddition between a leucine derived iminoester and tert-butyl acrylate, was studied. The comparison between ... -
Chiral self-recognition in a bispericyclic cyclodimerisation reaction of 1-azadienes
(RSC, 2023-10)Hermaphroditism of molecules: as in nature some species behave as male or female depending on the environment, herein we report a bispericyclic dimerisation of cyclic 1-azadienes where a molecule can behave as either diene ... -
Co-Catalyzed C(sp3)−H Oxidative Coupling of Glycine and Peptide Derivatives
(American Chemical Society, 2017-09-22)obalt-catalyzed selectiveα-alkylation andα-heteroarylation processes ofα-amino esters and peptide derivativesare described. These cross-dehydrogenative reactions occur undermild conditions and allow for the rapid assembly ... -
Conformational Flexibility as a Tool for Enabling Site-Selective Functionalization of Unactivated sp(3) C-O Bonds in Cyclic Acetals
(American Chemical Society, 2022)A dual catalytic manifold that enables site-selective functionalization of unactivated sp(3) C-O bonds in cyclic acetals with aryl and alkyl halides is reported. The reaction is triggered by an appropriate sigma*-p orbital ... -
Cross-Dehydrogenative Coupling Reactions for the Functionalization of α-Amino Acid Derivatives and Peptides
(Georg Thieme Verlag, 2018-06-25)The functionalization of typically unreactive C(sp3)–H bondsholds great promise for reducing the reliance on existing functionalgroups while improving atom-economy and energy efficiency. As a re-sult, this topic ... -
Cu-Catalyzed Site-Selective C(sp2)–H Radical Trifluoromethylation of Tryptophan Containing Peptides
(ACS Publications, 2020-02-13)Site-selective functionalization of C–H bonds within a peptide framework poses a challenging task of paramount synthetic relevance. Herein, we report an operationally simple C(sp2)–H trifluoromethylation of tryptophan ... -
Cyclotryptophan Mycotoxins: Short Synthesis of the Desymmetrized meso-Chimonantine Core of Leptosin C
(Georg Thieme, 2016-12-01)The desymmetrized meso-chimonantine core of leptosin C was prepared in a short stereoselective convergent sequence in 5 steps as the longest linear path from methyl l-tryptophan hydrochloride as starting material. The key ...