Examinar Artículos por departamento (eus.) "Kimika organikoa II"
Now showing items 21-40 of 67
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Generation of Tertiary and Quaternary Stereocenters via Palladium-Catalyzed Intramolecular Heck-type Reactions for the Stereocontrolled Synthesis of Pyrrolo[1,2-b]isoquinolines
(Wiley, 2016-04-05)The generation of quaternary and tertiary stereocenters on C-10 of the pyrroloisoquinoline skeleton through intramolecular Mizoroki-Heck reactions of 2-alkenyl substituted pyrroles and pyrrolidines has been studied. The ... -
Glycan structures and their interactions with proteins. A NMR view
(Elsevier, 2019-12)Carbohydrate molecules are essential actors in key biological events, being involved as recognition points for cell-cell and cell-matrix interactions related to health and disease. Despite outstanding advances in cryoEM, ... -
Glycans in drug discovery
(Royal Soc Chemistry, 2019-07-26)Glycans are key players in many biological processes. They are essential for protein folding and stability and act as recognition elements in cell-cell and cell-matrix interactions. Thus, being at the heart of medically ... -
Glycosyl Oxocarbenium Ions: Structure, Conformation, Reactivity, and Interactions
(American Chemical Society, 2021-06-01)Conspectus We also highlight that, from a chemical perspective, the glycosylation reaction can be described as a continuum, from unimolecular SN1 with naked oxocarbenium cations as intermediates to bimolecular SN2-type ... -
Hypoxia Reduces Cell Attachment of SARS-CoV-2 Spike Protein by Modulating the Expression of ACE2, Neuropilin-1, Syndecan-1 and Cellular Heparan Sulfate
(Taylor & Francis, 2021-06-06)A main clinical parameter of COVID-19 pathophysiology is hypoxia. Here we show that hypoxia decreases the attachment of the receptor-binding domain (RBD) and the S1 subunit (S1) of the spike protein of SARS-CoV-2 to ... -
Inter- and intramolecular enantioselective carbolithiation reactions
(Beilstein Institut, 2013-02)In this review we summarize recent developments in inter- and intramolecular enantioselective carbolithiation reactions carried out in the presence of a chiral ligand for lithium, such as (-)-sparteine, to promote facial ... -
Intramolecular Addition of Heteroaryllithiums onto Activated Alkenes. Access to Heterofused Indolizines and Pyrroloazepines
(Wiley, 2017-02-23)Heteroaryllithiums, obtained via MesLi mediated halogen- lithium exchange, undergo intramolecular addition onto acrylamide and acrylate moieties. Both electron rich (thiophenyl) and electron deficient (pyridinyl, quinolinyl) ... -
Intramolecular Palladium(II)-catalyzed 6-endo C-H alkenylation directed by the remote N-protecting group. Mechanistic insight and application to the synthesis of dihydroquinolines
(American Chemical Society, 2019-12-30)A protocol for the Pd(II)-catalyzed C-H alkenylation reaction of substituted N-allylanilines via an unusual 6-endo process has been developed. A DFT study of the mechanistic pathway has shown that the coordination of the ... -
Ion-pairing catalysis in the enantioselective addition of hydrazones to N-acyldihydropyrrole derivatives
(Royal Society of Chemistry, 2018-07-16)We have demonstrated that dihydropyrrole-based enamide derivatives can act as efficient precursors of chiral quaternary N-acyliminium salts under Brønsted acid catalysis that undergo reactions with hydrazones, the latter ... -
Kinetic Resolution of Secondary Allyl Boronates and Their Application in the Synthesis of Homoallylic Amines
(Wiley-VCH, 2018-09-02)Highly enantioenriched, chromatographically-stable secondary allyl boronates featuring a 1,1,2,2-tetraethyl-1,2-ethanediol fragment (Epin) were obtained by kinetic resolution of their racemic mixtures. The Epin group at ... -
Mechanistic Insights in the Mode of Action of Bifunctional Pyrrolidine-Squaramide-derived Organocatalysts
(Wiley-VCH, 2016)The modes of catalytic action of three squaramide-derived bifunctional organocatalysts have been investigated using DFT methods. The [5+2] cycloaddition between oxidopyrilium ylides and enals has been used as model ... -
Metal-Organic Frameworks and Zeolite Materials As Active Fillers for Lithium-Ion Battery Solid Polymer Electrolytes
(Royal Society Of Chemistry, 2021-06-21)The efforts to decarbonize the economies, with particular focus on renewable energies, must be accompanied by the development of more efficient and environmentally friendlier energy storage systems. In this context, all ... -
Molecular docking, SAR analysis and biophysical approaches in the study of the antibacterial activity of ceramides isolated from Cissus incisa
(Elsevier, 2021-02-18)The developing of antibacterial resistance is becoming in crisis. In this sense, natural products play a fundamental role in the discovery of antibacterial agents with diverse mechanisms of action. Phytochemical investigation ... -
Molecular Recognition in C-Type Lectins: The Cases of DC- SIGN, Langerin, MGL, and L-Sectin
(2020-11-02)Carbohydrates play a pivotal role in intercellular communication processes. In particular, glycan antigens are key for sustaining homeostasis, helping leukocytes to distinguish damaged tissues and invading pathogens from ... -
Mono and Di-Fucosylated Glycans of the Parasitic Worm S. Mansoniare Recognized Differently by the Innate Immune Receptor DC-SIGN
(Wiley, 2020-12-01)The parasitic worm,Schistosoma mansoni, expresses unusual fucosylated glycans in a stage-dependent manner that can be recognized by the human innate immune receptor DC-SIGN, thereby shaping host immune responses. We have ... -
Naphthyl-Containing Organophosphonate Derivatives of Keggin-Type Polyoxotungstates
(MDPI, 2016-06)New organophosphonate derivatives of monovacant Keggin-type polyoxotungstates that contain naphthyl groups have been synthesized and characterized in both solid state and solution. Single-crystal structural analysis shows ... -
Net-Net Auto Machine Learning (AutoML) Prediction of Complex Ecosystems
(Nature Publishing, 2018-08-17)Biological Ecosystem Networks (BENs) are webs of biological species (nodes) establishing trophic relationships (links). Experimental confirmation of all possible links is difficult and generates a huge volume of information. ... -
Net-Net AutoML Selection of Artificial Neural Network Topology for Brain Connectome Prediction
(MDPI, 2020-02-14)Brain Connectome Networks (BCNs) are defined by brain cortex regions (nodes) interacting with others by electrophysiological co-activation (edges). The experimental prediction of new interactions in BCNs represents a ... -
Novel carboxylate-based glycolipids: TLR4 antagonism, MD-2 binding and self-assembly properties
(Nature Publishing, 2019-01-29)New monosaccharide-based lipid A analogues were rationally designed through MD-2 docking studies. A panel of compounds with two carboxylate groups as phosphates bioisosteres, was synthesized with the same glucosamine-bis-succinyl ... -
Novel Dextran-Supported Biological Probes Decorated with Disaccharide Entities for Investigating the Carbohydrate-Protein Interactions of Gal-3.
(Wiley, 2018-11-30)The quest for novel natural-like biomolecular probes that can be used to gain information on biological recognition events is of topical interest to several scientific areas. In particular, the recognition of carbohydrates ...