Browsing Artículos by Author "Lacerda, Hadriano M."
Now showing items 1-4 of 4
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1-42 beta-Amyloid peptide requires PDK1/nPKC/Rac 1 pathway to induce neuronal death
Manterola, L.; Hernando Rodríguez, M.; Ruiz Núñez, Asier ; Apraiz, A.; Arrizabalaga Uriarte, Oskar ; Vellon, L.; Alberdi Alfonso, Elena María ; Cavaliere, Fabio; Lacerda, Hadriano M.; Jimenez, S.; Parada, L. A.; Matute Almau, Carlos José; Zugaza Gurruchaga, José Luis (Nature Publishing Group, 2013-01)1-42 beta-Amyloid (A beta(1-42)) peptide is a key molecule involved in the development of Alzheimer's disease. Some of its effects are manifested at the neuronal morphological level. These morphological changes involve ... -
Small GTPases of the Rab and Arf Families: Key Regulators of Intracellular Trafficking in Neurodegeneration
Arrazola Sastre, Alazne; Luque Montoro, Miriam; Lacerda, Hadriano M.; Llavero Bernal, Francisco; Zugaza Gurruchaga, José Luis (MDPI, 2021-04-23)Small guanosine triphosphatases (GTPases) of the Rab and Arf families are key regulators of vesicle formation and membrane trafficking. Membrane transport plays an important role in the central nervous system. In this ... -
Small GTPases of the Ras and Rho Families Switch on/off Signaling Pathways in Neurodegenerative Diseases
Arrazola Sastre, Alazne; Luque Montoro, Miriam; Gálvez Martín, Patricia; Lacerda, Hadriano M.; Lucía Mulas, Alejandro; Llavero Bernal, Francisco; Zugaza Gurruchaga, José Luis (MDPI, 2020-08-31)Small guanosine triphosphatases (GTPases) of the Ras superfamily are key regulators of many key cellular events such as proliferation, differentiation, cell cycle regulation, migration, or apoptosis. To control these ... -
The Tyrosine Phosphatase hPTPRβ Controls the Early Signals and Dopaminergic Cells Viability via the P2X7 Receptor
Llavero Bernal, Francisco; Luque Montoro, Miriam; Arrazola Sastre, Alazne; Lacerda, Hadriano M.; Zugaza Gurruchaga, José Luis (MDPI, 2021-11-29)ATP, one of the signaling molecules most commonly secreted in the nervous system and capable of stimulating multiple pathways, binds to the ionotropic purinergic receptors, in particular, the P2X7 receptor (P2X7R) and ...