Now showing items 1-4 of 4

    • Thumbnail

      1-42 beta-Amyloid peptide requires PDK1/nPKC/Rac 1 pathway to induce neuronal death 

      Manterola, L.; Hernando Rodríguez, M.; Ruiz Núñez, Asier ORCID; Apraiz, A.; Arrizabalaga Uriarte, Oskar ORCID; Vellon, L.; Alberdi Alfonso, Elena María ORCID; Cavaliere, Fabio; Lacerda, Hadriano M.; Jimenez, S.; Parada, L. A.; Matute Almau, Carlos José; Zugaza Gurruchaga, José Luis ORCID (Nature Publishing Group, 2013-01)
      1-42 beta-Amyloid (A beta(1-42)) peptide is a key molecule involved in the development of Alzheimer's disease. Some of its effects are manifested at the neuronal morphological level. These morphological changes involve ...
    • Thumbnail

      Small GTPases of the Rab and Arf Families: Key Regulators of Intracellular Trafficking in Neurodegeneration 

      Arrazola Sastre, Alazne; Luque Montoro, Miriam; Lacerda, Hadriano M.; Llavero Bernal, Francisco; Zugaza Gurruchaga, José Luis ORCID (MDPI, 2021-04-23)
      Small guanosine triphosphatases (GTPases) of the Rab and Arf families are key regulators of vesicle formation and membrane trafficking. Membrane transport plays an important role in the central nervous system. In this ...
    • Thumbnail

      Small GTPases of the Ras and Rho Families Switch on/off Signaling Pathways in Neurodegenerative Diseases 

      Arrazola Sastre, Alazne; Luque Montoro, Miriam; Gálvez Martín, Patricia; Lacerda, Hadriano M.; Lucía Mulas, Alejandro; Llavero Bernal, Francisco; Zugaza Gurruchaga, José Luis ORCID (MDPI, 2020-08-31)
      Small guanosine triphosphatases (GTPases) of the Ras superfamily are key regulators of many key cellular events such as proliferation, differentiation, cell cycle regulation, migration, or apoptosis. To control these ...
    • Thumbnail

      The Tyrosine Phosphatase hPTPRβ Controls the Early Signals and Dopaminergic Cells Viability via the P2X7 Receptor 

      Llavero Bernal, Francisco; Luque Montoro, Miriam; Arrazola Sastre, Alazne; Lacerda, Hadriano M.; Zugaza Gurruchaga, José Luis ORCID (MDPI, 2021-11-29)
      ATP, one of the signaling molecules most commonly secreted in the nervous system and capable of stimulating multiple pathways, binds to the ionotropic purinergic receptors, in particular, the P2X7 receptor (P2X7R) and ...