Now showing items 1-20 of 137

    • Thumbnail

      A colorectal cancer genome-wide association study in a Spanish cohort identifies two variants associated with colorectal cancer risk at 1p33 and 8p12 

      Fernández Rozadilla, Ceres; Cazier, Jean-Baptiste; Tomlinson, Ian P.; Carvajal Carmona, Luis G.; Palles, Claire; Lamas, María J.; Baiget, Montserrat; López Fernández, Luis A.; Brea Fernández, Alejandro; Abulí, Anna; Bujanda Fernández de Pierola, Luis; Clofent, Juan; González, Dolors; Xicola, Rosa; Andreu, Montserrat; Bessa, Xavier; Jover, Rodrigo; Llor, Xavier; Moreno, Víctor; Castells, Antoni; Carracedo, Angel; Castellví-Bel, Sergi; Ruiz Ponte, Clara; EPICOLON Consortium (BioMed Central, 2013-01)
      Background: Colorectal cancer (CRC) is a disease of complex aetiology, with much of the expected inherited risk being due to several common low risk variants. Genome-Wide Association Studies (GWAS) have identified 20 CRC ...
    • Thumbnail

      A High Degree of LINE-1 Hypomethylation Is a Unique Feature of Early-Onset Colorectal Cancer 

      Antelo, Marina; Balaguer, Francesc; Shia, Jinru; Shen, Yan; Hur, Keun; Moreira, Leticia; Cuatrecasas, Miriam; Bujanda Fernández de Pierola, Luis; Giraldez, María Dolores; Takahashi, Masanobu; Cabanne, Ana; Barugel, Mario Edmund; Arnold, Mildred; Roca, Enrique Luis; Andreu, Montserrat; Castellví-Bel, Sergi; Llor, Xavier; Jover, Rodrigo; Castells, Antoni; Boland, C. Richard; Goel, Ajay (Public Library of Science, 2012-09-25)
      Objective: Early-onset colorectal cancer (CRC) represents a clinically distinct form of CRC that is often associated with a poor prognosis. Methylation levels of genomic repeats such as LINE-1 elements have been recognized ...
    • Thumbnail

      A new approach to epigenome-wide discovery of non-invasive methylation biomarkers for colorectal cancer screening in circulating cell-free DNA using pooled samples 

      Gallardo-Gómez, María; Moran, Sebastian; Páez de la Cadena, María; Martínez-Zorzano, Vicenta Soledad; Rodríguez-Berrocal, Francisco Javier; Rodríguez-Girondo, Mar; Esteller, Manel; Cubiella, Joaquín; Bujanda Fernández de Pierola, Luis; Castells, Antoni; Balaguer, Francesc; Jover, Rodrigo; De Chiara, Loretta (Biomed Central, 2018-04-16)
      Background: Colorectal cancer is the fourth cause of cancer-related deaths worldwide, though detection at early stages associates with good prognosis. Thus, there is a clear demand for novel non-invasive tests for the early ...
    • Thumbnail

      A Novel Serum Metabolomic Profile for the Differential Diagnosis of Distal Cholangiocarcinoma and Pancreatic Ductal Adenocarcinoma 

      Macias, Rocio I. R.; Muñoz Bellvís, Luis; Sánchez Martín, Anabel; Arretxe Oliden, Enara; Martínez Arranz, Ibon; Lapitz Damborenea, Ainhoa; Gutiérrez, M. Laura; La Casta, Adelaida; Alonso, Cristina; González, Luis M.; Avila, Matias A.; Martinez-Chantar, Maria L.; Castro, Rui E.; Bujanda Fernández de Pierola, Luis; Bañales Asurmendi, Jesús María; Marin, José J. G. (MDPI, 2020-05-31)
      The diagnosis of adenocarcinomas located in the pancreas head, i.e., distal cholangiocarcinoma (dCCA) and pancreatic ductal adenocarcinoma (PDAC), constitutes a clinical challenge because they share many symptoms, are not ...
    • Thumbnail

      Acute depletion of diacylglycerol from the cis -Golgi affects localized nuclear envelope morphology during mitosis 

      Chung, Gary Hong Chun; Domart, Marie-Charlotte; Peddie, Christopher; Mantell, Judith; Mclaverty, Kieran; Arabiotorre, Angela; Hodgson, Lorna; Byrne, Richard D.; Verkade, Paul; Arkill, Kenton; Collinson, Lucy M.; Larijani, Banafshé (American Society for Biochemistry and Molecular Biology, 2018-08)
      Dysregulation of nuclear envelope (NE) assembly results in various cancers; for example, renal and some lung carcinomas ensue due to NE malformation. The NE is a dynamic membrane compartment and its completion during mitosis ...
    • Thumbnail

      Acute L-DOPA administration reverses changes in firing pattern and low frequency oscillatory activity in the entopeduncular nucleus from long term L-DOPA treated 6-OHDA-lesioned rats 

      Aristieta Arbelaiz, Asier; Ruiz Ortega, José Ángel; Morera Herreras, Teresa; Miguélez Palomo, Cristina; Ugedo Urruela, Luisa (Elsevier, 2019-12)
      The pathophysiology of Parkinson's disease (PD) and L-DOPA-induced dyskinesia (LID) is associated with aberrant neuronal activity and abnormal high levels of oscillatory activity and synchronization in several basal ganglia ...
    • Thumbnail

      Adaptive Downregulation of Cl-/HCO3- Exchange Activity in Rat Hepatocytes under Experimental Obstructive Cholestasis 

      Miszczuk, Gisel S.; Bañales Asurmendi, Jesús María; Zucchetti, Andrés E.; Pisani, Gerardo B.; Boaglio, Andrea C.; Sáez, Elena; Medina, Juan F.; Roma, Marcelo G.; Crocenzi, Fernando A. (Public Library Science, 2019-02-21)
      In obstructive cholestasis, there is an integral adaptive response aimed to diminish the bile flow and minimize the injury of bile ducts caused by increased intraluminal pressure and harmful levels of bile salts and ...
    • Thumbnail

      Adiponectin, leptin, and IGF-1 are useful diagnostic and stratification biomarkers of NAFLD 

      Marques, Vanda; Afonso, Marta Bento; Bierig, Nina; Duarte-Ramos, Filipa; Santos Laso, Álvaro; Jiménez Agüero, Raúl; Eizaguirre Letamendia, Emma; Bujanda Fernández de Pierola, Luis; Pareja Megía, María J.; Luís, Rita; Costa, Adília; Machado, Mariana Verdelho; Alonso, Cristina; Arretxe Oliden, Enara; Alustiza Echeberria, José María; Krawczyk, Marcin; Lammert, Frank; Tiniakos, Dina G.; Flehmig, Bertram; Cortez-Pinto, Helena; Bañales Asurmendi, Jesús María; Castro, Rui E.; Normann, Andrea; Rodrigues, Cecilia M. P. (Frontiers Media, 2021-06-23)
      [EN] Background: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease where liver biopsy remains the gold standard for diagnosis. Here we aimed to evaluate the role of circulating adiponectin, ...
    • Thumbnail

      Analysis of A 6-Mirna Signature in Serum from Colorectal Cancer Screening Participants as Non-Invasive Biomarkers for Advanced Adenoma and Colorectal Cancer Detection 

      Marcuello, Maria; Duran Sanchon, Saray; Moreno, Lorena; Lozano, Juan José; Bujanda Fernández de Pierola, Luis; Castells, Antoni; Gironella, Meritxell (MDPI, 2019-10-12)
      Early detection of colorectal cancer (CRC) and its precancerous lesion, advanced adenomas (AA), is critical to improve CRC incidence and prognosis. Circulating microRNAs (miRNAs or miR) are promising non-invasive biomarkers ...
    • Thumbnail

      Analysis of Plasminogen Genetic Variants in Multiple Sclerosis Patients 

      Sadovnick, A. Dessa; Traboulsee, Anthony L.; Bernales, Cecily Q.; Ross, Jay P.; Forwell, Amanda L.; Yee, Irene M.; Guillot-Noel, Lena; Fontaine, Bertrand; Cournu-Rebeix, Isabelle; Alcina, Antonio; Fedetz, María; Izquierdo, Guillermo; Matesanz, Fuencisla; Hilven, Kelly; Goris, An; Astobiza Pérez, Janire; Alloza Moral, Iraide; Rodríguez-Antigüedad Zarranz, Alfredo; Vandenbroeck, Koen; Akkad, Denis A.; Aktas, Orhan; Blaschke, Paul; Buttmann, Mathias; Chan, Andrew; Epplen, Joerg T.; Gerdes, Lisa-Ann; Kroner, Antje; Kubisch, Christian; Kümpfel, Tania; Lohse, Peter; Rieckmann, Peter; Zettl, Uwe K.; Zipp, Frauke; Bertram, Lars; Lill, Christina M.; Fernández, Óscar; Urbaneja, Patricia; Leyva, Laura; Alvarez-Cermeño, José Carlos; Arroyo, Rafael; Garagorri, Aroa M.; García-Martínez, Angel; Villar, Luisa M.; Urcelay, Elena; Malhotra, Sunny; Montalbán, Xavier; Comabella, Manuel; Berger, Thomas; Fazekas, Franz; Reindl, Markus; Schmied, Mascha C.; Zimprich, Alexander; Vilariño-Güell, Carles (Genetics Society of America, 2016-07-01)
      Multiple sclerosis (MS) is a prevalent neurological disease of complex etiology. Here, we describe the characterization of a multi-incident MS family that nominated a rare missense variant (p.G420D) in plasminogen (PLG) ...
    • Thumbnail

      Analysis of SARS-CoV-2 reverse transcription-quantitative polymerase chain reaction cycle threshold values vis-à-vis anti-SARS-CoV-2 antibodies from a high incidence region 

      Markewitz, Robert; Torge, Antje; Wandinger, Klaus-Peter; Pauli, Daniela; Dargvainiene, Justina; Franke, Andre; Bujanda Fernández de Pierola, Luis; Marimón Ortiz de Zarate, José María; Bañales Asurmendi, Jesús María; Gutiérrez Stampa, María Angeles; Nafría, Beatriz; Junker, Ralf (Elsevier, 2021-07-14)
      OBJECTIVES: To examine the relationship between antibody status and cycle threshold (Ct) values, the prognostic value of the latter for COVID-19 patients, and the inter-assay comparability of SARS-CoV-2 Ct values. METHODS: ...
    • Thumbnail

      Anti-Inflammatory and Immunosuppressive Drugs and Reproduction 

      Ostensen, Monika; Khamashta, Munther; Lockshin, Michael; Parke, Ann; Brucato, Antonio; Carp, Howard; Doria, Andrea; Rai, Raj; Meroni, Pierluigi; Cetin, Irene; Derksen, Ronald; Branch, Ware; Motta, Mario; Gordon, Caroline; Ruiz Irastorza, Guillermo; Spinillo, Arsenio; Friedman, Deborah; Cimaz, Rolando; Czeizel, Andrew; Piette, Charles Piette; Cervera, Ricard; Levy, Roger A.; Clementi, Maurizio; De Carolis, Sara; Petri, Michelle; Shoenfeld, Yehuda; Faden, David; Valesini, Guido; Tincani, Angela (Biomed Central, 2006-05-11)
      Rheumatic diseases in women of childbearing years may necessitate drug treatment during a pregnancy, to control maternal disease activity and to ensure a successful pregnancy outcome. This survey is based on a consensus ...
    • Thumbnail

      Anti-miR-518d-5p Overcomes Liver Tumor Cell Death Resistance Through Mitochondrial Activity 

      Fernández Tussy, Pablo; Rodríguez Agudo, Rubén; Fernández Ramos, David; Barbier Torres, Lucía; Zubiete Franco, Imanol; López de Davalillo, Sergio; Herráez Aguilar, Elisa; Goikoetxea Usandizaga, Naroa; Lachiondo Ortega, Sofía; Simón Espinosa, Jorge; Lopitz Otsoa, Fernando; Gutiérrez de Juan, Virginia; McCain, Misti V.; Perugorria Montiel, María Jesús; Mabe Alvarez, Jon; Navasa, Nicolás; Rodrigues, Cecilia M. P.; Fabregat, Isabel; Boix, Loreto; Sapena, Victor; Anguita Castillo, Juan de Dios; Lu, Shelly C.; Mato de la Paz, José María; Bañales Asurmendi, Jesús María; Villa, Erica; Reeves, Helen L.; Bruix, Jordi; Reig, María; Marín, José J. G.; Cardoso Delgado, Teresa de Jesús; Martínez Chantar, María Luz (Springer Nature, 2021-05-28)
      Dysregulation of miRNAs is a hallmark of cancer, modulating oncogenes, tumor suppressors, and drug responsiveness. The multi-kinase inhibitor sorafenib is one of the first-line drugs for advanced hepatocellular carcinoma ...
    • Thumbnail

      Antimicrobial susceptibility testing before first-line treatment for Helicobacter pylori infection in patients with dual or triple antibiotic resistance 

      Cosme Jiménez, Ángel; Montes, Milagrosa; Ibarra, Begoña; Tamayo, Esther; Alonso Galán, Horacio; Mendarte, Usua; Lizasoain Urcola, Jacobo María; Herreros Villanueva, Marta; Bujanda Fernández de Pierola, Luis (Baishideng Publishing, 2017-05-14)
      AIM To evaluate the efficacy of antimicrobial susceptibility-guided therapy before first-line treatment for infection in patients with dual or triple antibiotic resistance. METHODS A total of 1034 patients infected ...
    • Thumbnail

      Antitumor Necrosis Factor Agents to Treat EndoscopicPostoperative Recurrence of Crohn’s Disease: A Nationwide Study With Propensity-Matched Score Analysis 

      Cañete, Fiorella; Mañosa, Míriam; Pérez Martínez, Isabel; Barreiro de Acosta, Manuel; González Sueyro, Ramiro C.; Nos, Pilar; Iglesias Flores, Eva; Gutiérrez, Ana; Bujanda Fernández de Pierola, Luis; Gordillo, Jordi; Ríos León, Raquel; Casanova, María José; Villoria, Albert; Rodríguez Lago, Iago; López Serrano, Pilar; García Herola, Antonio; Ramírez de la Piscina, Patricia; Navarro Llavat, Mercè; Taxonera, Carlos; Barrio, Jesús; Ramos, Laura; Navarro, Pablo; Benítez Leiva, Olga; Calafat, Margalida; Domènech, Eugeni; INFLIRECU study (Lippincott Williams & Wilkins, 2020-08)
      INTRODUCTION:Patients with Crohn's disease experiencing endoscopic postoperative recurrence (POR) may benefit from antitumor necrosis factor (TNF) agents but scarce data on this are available. Our aim was to assess the ...
    • Thumbnail

      Assessment of the consequences of caregiving in psychosis: a psychometric comparison of the Zarit Burden Interview (ZBI) and the Involvement Evaluation Questionnaire (IEQ) 

      Gonçalves-Pereira, Manuel; González-Fraile, Eduardo; Santos Zorrozúa, Borja; Martín-Carrasco, Manuel; Fernández-Catalina, Paola; Domínguez-Panchón, Ana I.; Muñoz-Hermoso, Paula; Ballesteros, Javier (Biomed Central, 2017-04-05)
      Background: The Zarit Burden Interview ( ZBI) was originally developed to assess the level of subjective burden in caregivers of people with dementia. The Involvement Evaluation Questionnaire ( IEQ) is amongst the leading ...
    • Thumbnail

      Association between CASP8-652 6N Del Polymorphism (rs3834129) and Colorectal Cancer Risk: Results from a Multi-Centric Study 

      Pardini, Barbara; Verderio, Paolo; Pizzamiglio, Sara; Nici, Carmela; Maiorana, Maria Valeria; Naccarati, Alessio; Vodickova, Ludmila; Vymetalkova, Veronika; Veneroni, Silvia; Daidone, Maria Grazia; Ravagnani, Fernando; Bianchi, Tiziana; Bujanda Fernández de Pierola, Luis; Carracedo, Angel; Castells, Antoni; Ruiz Ponte, Clara; Morreau, Hans; Howarth, Kimberley; Jones, Angela; Castellví-Bel, Sergi; Li, Li; Tomlinson, Ian; Van Wezel, Tom; Vodicka, Pavel; Radice, Paolo; Peterlongo, Paolo; EPICOLON Consortium (Public Library Science, 2014-01)
      The common 2652 6N del variant in the CASP8 promoter (rs3834129) has been described as a putative low-penetrance risk factor for different cancer types. In particular, some studies suggested that the deleted allele (del) ...
    • Thumbnail

      Associations between Dietary Polyphenols and Type 2 Diabetes in a Cross-Sectional Analysis of the PREDIMED-Plus Trial: Role of Body Mass Index and Sex 

      Tresserra Rimbau, Anna; Castro Barquero, Sara; Vitelli Storelli, Facundo; Becerra Tomás, Nerea; Vázquez Ruiz, Zenaida; Díaz López, Andrés; Corella, Dolores; Castañer, Olga; Romaguera, Dora; Vioque, Jesús; Alonso Gómez, Ángel María; Warnberg, Julia; Martínez, José Alfredo; Serra Majem, Lluís; Estruch, Ramón; Tinahones, Francisco J.; Lapetra, José; Pintó, Xavier; Tur, Josep A.; López Miranda, José; García Molina, Laura; Delgado Rodríguez, Miguel; Matía Martín, Pilar; Daimiel, Lidia; Rubín García, María; Vidal, Josep; Galdón, Alba; Ros, Emilio; Basterra Gortari, Francisco Javier; Babio, Nancy; Sorli, José Vicente; Hernáez, Álvaro; Konieczna, Jadwiga; Notario Barandiaran, Leyre; Tojal Sierra, Lucas; Pérez López, Jessica; Abete, Itziar; Álvarez Pérez, Jacqueline; Fernández García, José Carlos; Santos Lozano, José Manuel; Galera Cusí, Ana; Julibert, Alicia; Ruiz Canela, Miguel; Martinez Lacruz, Raúl; Pérez Vega, Karla Alejandra; Galmes Panades, Aina María; Pastor Polo, Concepción; Moreno Rodríguez, Anai; Gea, Alfredo; Fitó, Montserrat; Lamuela Raventos, Rosa María; Salas Salvadó, Jordi (MDPI, 2019-11-08)
      Overweight and obesity are important risk factors for type 2 diabetes (T2D). Moving towards healthier diets, namely, diets rich in bioactive compounds, could decrease the odds of suffering T2D. However, those individuals ...
    • Thumbnail

      Brain connectivity and cognitive functioning in individuals six months after multiorgan failure 

      Jiménez Marín, Antonio; Rivera, Diego; Boado, Victoria; Diez, Ibai; Labayen Beraza, Fermín; Garrido, Irati; Ramos Usuga, Daniela; Benito Sánchez, Itziar; Rasero, Javier; Cabrera Zubizarreta, Alberto; Gabilondo Cuellar, Iñigo; Stramaglia, Sebastiano; Arango Lasprilla, Juan Carlos; Cortés Díaz, Jesús María (Elsevier, 2019-12)
      Abstract Multiorgan failure (MOF) is a life-threating condition that affects two or more systems of organs not involved in the disorder that motivates admission to an Intensive Care Unit (ICU). Patients who survive MOF ...
    • Thumbnail

      Broad Phenotypes of Disorders/Differences of Sex Development in MAMLD1 Patients Through Oligogenic Disease 

      Flueck, Christa E.; Audi, Laura; Fernández Cancio, Mónica; Sauter, Kay Sara; Martínez de la Piscina Martín, Idoia; Castaño González, Luis Antonio; Esteva, Isabel; Camats, Nuria (Frontiers Media, 2019-08-29)
      Disorders/differences of sex development (DSD) are the result of a discordance between chromosomal, gonadal, and genital sex. DSD may be due to mutations in any of the genes involved in sex determination and development ...