Now showing items 1-20 of 256

    • Thumbnail

      1-42 beta-Amyloid peptide requires PDK1/nPKC/Rac 1 pathway to induce neuronal death 

      Manterola, L.; Hernando Rodríguez, M.; Ruiz Núñez, Asier; Apraiz, A.; Arrizabalaga Uriarte, Oskar; Vellon, L.; Alberdi Alfonso, Elena María; Cavaliere, Fabio; Lacerda, Hadriano M.; Jimenez, S.; Parada, L. A.; Matute Almau, Carlos José; Zugaza Gurruchaga, José Luis (Nature Publishing Group, 2013-01)
      1-42 beta-Amyloid (A beta(1-42)) peptide is a key molecule involved in the development of Alzheimer's disease. Some of its effects are manifested at the neuronal morphological level. These morphological changes involve ...
    • Thumbnail

      A 4-Trifluoromethyl Analogue of Celecoxib Inhibits Arthritis by Suppressing Innate Immune Cell Activation 

      Chiba, Asako; Mizuno, Miho; Tomi, Chiharu; Tajima, Ryohsuke; Alloza Moral, Iraide; Di Penta, Alessandra; Yamamura, Takashi; Vandenbroeck, Koen; Miyake, Sachiko (Biomed Central, 2012-01-17)
      Introduction: Celecoxib, a highly specific cyclooxygenase-2 (COX-2) inhibitor has been reported to have COX-2-independent immunomodulatory effects. However, celecoxib itself has only mild suppressive effects on arthritis. ...
    • Thumbnail

      A beta oligomers promote oligodendrocyte differentiation and maturation via integrin beta 1 and Fyn kinase signaling 

      Quintela López, Tania; Ortiz Sanz, Carolina; Serrano Regal, María Paz; Gaminde Blasco, Adhara Mikaela; Valero Gómez-Lobo, Jorge; Baleriola, Jimena; Sánchez Gómez, María Victoria; Matute Almau, Carlos José; Alberdi Alfonso, Elena María (Nature Publishing Group, 2019-06-06)
      Alzheimer's disease (AD) is characterized by a progressive cognitive decline that correlates with the levels of amyloid beta-peptide (A beta) oligomers. Strong evidences connect changes of oligodendrocyte function with the ...
    • Thumbnail

      A Clonal NG2-Glia Cell Response in a Mouse Model of Multiple Sclerosis 

      Barriola, Sonsoles; Pérez Cerdá, Fernando; Matute Almau, Carlos José; Bribián, Ana; López Mascaraque, Laura (MDPI, 2020-05-21)
      NG2-glia, also known as oligodendrocyte precursor cells (OPCs), have the potential to generate new mature oligodendrocytes and thus, to contribute to tissue repair in demyelinating diseases like multiple sclerosis (MS). ...
    • Thumbnail

      A deep intronic splice variant advises reexamination of presumably dominant SPG7 Cases 

      Verdura, Edgard; Schlüter, Agatha; Fernández Eulate, Gorka; Ramos Martín, Raquel; Zulaica, Miren; Planas Serra, Laura; Ruiz, Montserrat; Fourcade, Stéphane; Casasnovas, Carlos; López de Munain Arregui, Adolfo José (Wiley, 2020-01)
      Objective To identify causative mutations in a patient affected by ataxia and spastic paraplegia. Methods Whole-exome sequencing (WES) and whole-genome sequencing (WGS) were performed using patient's DNA sample. RT-PCR and ...
    • Thumbnail

      A Genotyping Method Combining Primer Competition PCR with HRM Analysis to Identify Point Mutations in Duchenne Animal Models 

      Lasa Fernández, Haizpea; Mosqueira Martín, Laura; Alzualde, Ainhoa; Lasa Elgarresta, Jaione; Vallejo Illaramendi, Ainara (Nature, 2020-10-14)
      Dystrophin-null sapje zebrafish is an excellent model for better understanding the pathological mechanisms underlying Duchenne muscular dystrophy, and it has recently arisen as a powerful tool for high-throughput screening ...
    • Thumbnail

      A Model of Ischemia-Induced Neuroblast Activation in the Adult Subventricular Zone 

      Vergni, Davide; Castiglione, Filippo; Briani, Maya; Middei, Silvia; Alberdi Alfonso, Elena María; Reymann, Klaus G.; Natalini, Roberto; Volonté, Cinzia; Matute Almau, Carlos José; Cavaliere, Fabio (Public Library of Science, 2009-04-23)
      We have developed a rat brain organotypic culture model, in which tissue slices contain cortex-subventricular zone-striatum regions, to model neuroblast activity in response to in vitro ischemia. Neuroblast activation has ...
    • Thumbnail

      A Multicentre, Randomised, Controlled Trial of a Combined Clinical Treatment for First-Episode Psychosis 

      González Ortega, Itxaso; Vega Pérez, Patricia; Echeburúa Odriozola, Enrique; Alberich, Susana; Fernández Sevillano, Jessica; Barbeito, Sara; Balanzá Martínez, Vicent; Vieta, Eduard; Lorente-Rovira, Esther; Luengo, Ana; Cerrillo, Ester; Crespo, José Manuel; Matute Almau, Carlos José; González Pinto Arrillaga, Ana María (MDPI, 2021-07-06)
      Introduction: There is evidence that early intervention contributes to improving the prognosis and course of first-episode psychosis (FEP). However, further randomised treatment clinical trials are needed. Objectives: The ...
    • Thumbnail

      A neural extracellular matrix-based method for in vitro hippocampal neuron culture and dopaminergic differentiation of neural stem cells 

      García Parra, Patricia; Maroto, Marcos; Cavaliere, Fabio; Naldaiz Gastesi, Neia; Álava, José I.; García, Antonio G.; López de Munain Arregui, Adolfo José; Izeta Permisán, Ander (BioMed Central, 2013)
      Background: The ability to recreate an optimal cellular microenvironment is critical to understand neuronal behavior and functionality in vitro. An organized neural extracellular matrix (nECM) promotes neural cell ...
    • Thumbnail

      A Neuron, Microglia, and Astrocyte Triple Co-culture Model to Study Alzheimer’s Disease 

      Luchena Moreno, Celia; Zuazo Ibarra, Jone; Valero Gómez-Lobo, Jorge; Matute Almau, Carlos José; Alberdi Alfonso, Elena María; Capetillo González de Zarate, Estibaliz (Frontiers Media, 2022-04-14)
      Glial cells are essential to understand Alzheimer's disease (AD) progression, given their role in neuroinflammation and neurodegeneration. There is a need for reliable and easy to manipulate models that allow studying the ...
    • Thumbnail

      A new approach based on targeted pooled DNA sequencing identifies novel mutations in patients with Inherited Retinal Dystrophies 

      Ezquerra-Inchausti, Maitane; Anasagasti, Ander; Barandika, Olatz; Garai-Aramburu, Gonzaga; Galdós, Marta; López de Munain Arregui, Adolfo José; Irigoyen, Cristina; Ruiz-Ederra, Javier (Nature Publishing, 2018-09-18)
      Inherited retinal diseases (IRD) are a heterogeneous group of diseases that mainly affect the retina; more than 250 genes have been linked to the disease and more than 20 different clinical phenotypes have been described. ...
    • Thumbnail

      A novel form of human disease with a protease-sensitive prion protein and heterozygosity methionine/valine at codon 129: Case report 

      Rodríguez Martínez, Ana B.; Garrido Urkullu, Joseba M.; Zarranz Imirizaldu, Juan José; Arteagoitia, Jose M.; Martínez de Pancorbo Gómez, María de los Angeles; Atares, Begona; Bilbao, Miren J.; Ferrer, Isidro; Juste Jordán, Ramón A. (BioMed Central, 2010-10)
      Background: Sporadic Creutzfeldt-Jakob disease (sCJD) is a rare neurodegenerative disorder in humans included in the group of Transmissible Spongiform Encephalopathies or prion diseases. The vast majority of sCJD cases are ...
    • Thumbnail

      A qualitative research of adolescents with behavioral problems about their experience in a dialectical behavior therapy skills training group 

      Sesma Pardo, Eva; Fernández Rivas, Aranzazu; Orgaz Barnier, Pablo; Beá Mirabent, Marina; Kerexeta Lizeaga, Iñaki; Díaz Cosgaya, Aída; Catalán Alcántara, Ana; Vivanco González, Esther; Aguirre, Blaise; González Torres, Miguel Ángel (BMC, 2020-05-19)
      BACKGROUND: Several quantitative studies support the effectiveness of the Dialectical Behavior Therapy (DBT) psychosocial skills training group component for adolescents with impulse-control disorder and/or emotional ...
    • Thumbnail

      A systematic review of sex-based differences in effectiveness and adverse effects of clozapine 

      Alberich, Susana; Fernández Sevillano, Jessica; González Ortega, Itxaso; Usall, Judith; Sáenz Herrero, Margarita; González Fraile, Eduardo; González Pinto Arrillaga, Ana María (Elsevier, 2019-08-03)
      Clozapine is one of the most widely used antipsychotics for treating psychiatric illnesses such as schizophrenia and bipolar disorder. This drug, however, is associated with adverse effects such as weight gain, metabolic ...
    • Thumbnail

      A Trifluoromethyl Analogue of Celecoxib Exerts Beneficial Effects in Neuroinflammation 

      Di Penta, Alessandra; Chiba, Asako; Alloza Moral, Iraide; Wyssenbach Ibarra, Ane; Yamamura, Takashi; Villoslada, Pablo; Miyake, Sachiko; Vandenbroeck, Koen (Public Library of Science, 2013-12-11)
      Celecoxib is a selective cyclooxygenase-2 (COX2) inhibitor. We have previously shown that celecoxib inhibits experimental autoimmune encephalomyelitis (EAE) in COX-2-deficient mice, suggestive for a mode of action involving ...
    • Thumbnail

      Acetylome in Human Fibroblasts From Parkinson's Disease Patients 

      Yakhine Diop, Sokhna M. S.; Rodríguez Arribas, Mario; Martínez Chacón, Guadalupe; Uribe Carretero, Elisabet; Gómez Sánchez, Rubén; Aiastui, Ana; López de Munain Arregui, Adolfo José; Bravo San Pedro, José M.; Niso Santano, Mireia; González Polo, Rosa A.; Fuentes Rodríguez, José Manuel (Frontiers Media SA, 2018-04-17)
      Parkinson's disease (PD) is amultifactorial neurodegenerative disorder. The pathogenesis of this disease is associated with gene and environmental factors. Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most ...
    • Thumbnail

      Age-dependent decrease in glutamine synthetase expression in the hippocampal astroglia of the triple transgenic Alzheimer's disease mouse model : mechanism for deficient glutamatergic transmission? 

      Olabarria, Markel; Noristani, Harun N.; Verkhratsky, Alexei; Rodríguez Arellano, José Julio (BioMed Central, 2011-07-30)
      Astrocytes are fundamental for brain homeostasis and the progression and outcome of many neuropathologies including Alzheimer's disease (AD). In the triple transgenic mouse model of AD (3xTg-AD) generalised hippocampal ...
    • Thumbnail

      Age‐related cognitive decline in myotonic dystrophy type 1: An 11‐year longitudinal follow‐up study 

      Labayru Isusquiza, Garazi; Aliri Lazcano, Jone; Zulaica, Miren; López de Munain Arregui, Adolfo José; Sistiaga Berrondo, Andone (Wiley, 2020-03)
      Background Myotonic dystrophy type 1 (DM1) is an inherited multi-systemic disease involving the central nervous system (CNS) and is consequently characterized by a range of cognitive impairments. However, whether this ...
    • Thumbnail

      Alterations of the Hippocampal Neurogenic Niche in a Mouse Model of Dravet Syndrome 

      Martín Suárez, Soraya; Abiega Etxabe, Oihane; Ricobaraza, Ana; Hernández Alcoceba, Rubén; Encinas Pérez, Juan Manuel (Frontiers Media, 2020-07-21)
      Hippocampal neurogenesis, the process by which neural stem cells (NSCs) continuously generate new neurons in the dentate gyrus (DG) of most mammals including humans, is chiefly regulated by neuronal activity. Thus, severe ...
    • Thumbnail

      Altered expression of Alzheimer's disease-related genes in the cerebellum of autistic patients: a model for disrupted brain connectome and therapy 

      Zeidán-Chuliá, F.; Oliveira, B-HN de; Salmina, AB; Casanova, MF; Gelain, DP; Noda, M; Verkhratsky, Alexei; Moreira, J CF (Nature Publishing Group, 2014-05)
      Autism and Alzheimer's disease (AD) are, respectively, neurodevelopmental and degenerative diseases with an increasing epidemiological burden. The AD-associated amyloid-beta precursor protein-alpha has been shown to be ...