Now showing items 1-20 of 110

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      A Customized Pigmentation SNP Array Identifies a Novel SNP Associated with Melanoma Predisposition in the SLC45A2 Gene 

      Ibarrola Villava, Maider; Fernandez, Lara P.; Alonso Alegre, Santos; Boyano López, María Dolores; Peña Chilet, María; Pita, Guillermo; Avilés, José A.; Mayor, Matias; Gómez Fernández, Cristina; Casado, Beatriz; Martín González, Manuel; Izagirre Arribalzaga, Neskuts; De la Rúa Vaca, Concepción; Asumendi Mallea, Aintzane; Pérez-Yarza Pérez-Irezabal, Gorka; Arroyo Berdugo, Yoana; Boldo, Enrique; Lozoya, Rafael; Torrijos Aguilar, Arantxa; Pitarch, Ana; Pitarch, Gerard; Sánchez Motilla, José M.; Valcuende Cavero, Francisca; Tomás Cabedo, Gloria; Pérez Pastor, Gemma; Díaz Pérez, José Luis; Gardeazabal García, Jesús; Martínez de Lizarduy, Iñigo; Sánchez Díez, Ana; Valdés, Carlos; Pizarro, Angel; Casado, Mariano; Carretero, Gregorio; Botella Estrada, Rafael; Nagore, Eduardo; Lázaro, Pablo; Lluch, Ana; Benítez, Javier; Martínez Cadenas, Conrado; Ribas, Gloria (Public Library of Science, 2011-04-29)
      As the incidence of Malignant Melanoma (MM) reflects an interaction between skin colour and UV exposure, variations in genes implicated in pigmentation and tanning response to UV may be associated with susceptibility to ...
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      A manual-based family intervention for families living with the consequences of traumatic injury to the brain or spinal cord: a study protocol of a randomized controlled trial 

      Langer Soendergaard, Pernille; Moth Wolffbrandt, Mia; Biering Sørensen, Fin; Nordin, Malin; Schow, Trine; Arango Lasprilla, Juan Carlos; Norup, Anne (BMC, 2019-11-27)
      Background Acquiring a traumatic injury constitutes a severe life change for the survivor, but also for the surrounding family. The paradigm of helping the family has primarily been on psychosocial interventions targeting ...
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      A novel brain partition highlights the modular skeleton shared by structure and function 

      Diez Palacio, Ibai; Bonifazi, Paolo; Escudero, Iñaki; Mateos, Beatriz; Muñoz, Miguel A.; Stramaglia, Sebastiano; Cortés Díaz, Jesús María (Nature Publishing Group, 2015-06-03)
      Elucidating the intricate relationship between brain structure and function, both in healthy and pathological conditions, is a key challenge for modern neuroscience. Recent progress in neuroimaging has helped advance our ...
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      A Study of the Printability of Alginate-Based Bioinks by 3D Bioprinting for Articular Cartilage Tissue Engineering 

      Gorroñogoitia, Izar; Urtaza, Uzuri; Zubiarrain Laserna, Ana; Alonso Varona, Ana Isabel; Zaldua Huici, Ane Miren (MDPI, 2022-01-17)
      Three-dimensional bioprinting combined with natural hydrogels is a promising technology for the treatment of several pathologies and different tissue regeneration. One of the most studied tissues is cartilage, a complex ...
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      A UHPLC-Mass Spectrometry View of Human Melanocytic Cells Uncovers Potential Lipid Biomarkers of Melanoma 

      Pérez Valle, Arantza; Abad García, Beatriz; Fresnedo Aranguren, María Olatz; Barreda Gómez, Gabriel; Aspichueta Celaá, Patricia; Asumendi Mallea, Aintzane; Astigarraga Arribas, Egoitz; Fernández González, José Andrés; Boyano López, María Dolores; Ochoa Olascoaga, Begoña (MDPI, 2021-10-08)
      Melanoma is the deadliest form of skin cancer due to its ability to colonize distant sites and initiate metastasis. Although these processes largely depend on the lipid-based cell membrane scaffold, our understanding of ...
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      Adenylate Cyclase Toxin promotes bacterial internalisation into non phagocytic cells 

      Martín Plágaro, César Augusto; Etxaniz Iriondo, Asier; Belloso Uribe, Kepa; Etxebarria Gallego, Aitor; González Bullón, David; Arlucea de Jaureguizar, Jon Andoni; Goñi Urcelay, Félix María; Arechaga Martínez, Juan Miguel; Ostolaza Echabe, Elena Amaya (Nature Publishing Group, 2015-09-08)
      Bordetella pertussis causes whooping cough, a respiratory infectious disease that is the fifth largest cause of vaccine-preventable death in infants. Though historically considered an extracellular pathogen, this bacterium ...
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      Advances and Perspectives in Dental Pulp Stem Cell Based Neuroregeneration Therapies 

      Luzuriaga González, Jon; Polo Arroyabe, Yurena; Pastor Alonso, Oier; Pardo Rodríguez, Beatriz; Larrañaga Espartero, Aitor; Unda Rodríguez, Fernando José; Sarasua Oiz, José Ramón; Pineda Martí, José Ramón; Ibarretxe Bilbao, Gaskon (MDPI, 2021-03-29)
      Human dental pulp stem cells (hDPSCs) are some of the most promising stem cell types for regenerative therapies given their ability to grow in the absence of serum and their realistic possibility to be used in autologous ...
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      Altered expression of fibroblast activation protein-α (FAP) in colorectal adenoma-carcinoma sequence and in lymph node and liver metastases 

      Solano Iturri, Jon Danel; Beitia Loinaz, Maider; Errarte Yarza, Peio; Calvete Candenas, Julio; Etxezarraga Zuluaga, María Carmen; Loizate Totoricagüena, Alberto; Echevarría Orella, Enrique; Badiola Echaburu, Iker; Larrinaga Embeita, Gorka (Impact Journals, 2020-06-15)
      Colorectal cancer (CRC) is a major health problem in elderly people because of its high incidence and high mortality rate. Despite early screening programs, more than half of CRC patients are diagnosed at advanced stages. ...
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      An E2F7-Dependent Transcriptional Program Modulates DNA Damage Repair And Genomic Stability 

      Mitxelena Sánchez, Jone; Apraiz García, Aintzane; Vallejo Rodríguez, Jon; García Santisteban, Iraia; Fullaondo Elordui-Zapaterieche, Asier; Alvarez Fernández, Mónica; Marcos, Marcos; Zubiaga Elordieta, Ana María (Oxford University Press, 2018-05-18)
      The cellular response to DNA damage is essential for maintaining the integrity of the genome. Recent evidence has identified E2F7 as a key player in DNA damage-dependent transcriptional regulation of cell-cycle genes. ...
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      An Integrative Omics Approach Reveals Involvement of BRCA1 in Hepatic Metastatic Progression of Colorectal Cancer 

      Gerovska, Daniela; Larrinaga Embeita, Gorka; Solano Iturri, Jon Danel; Márquez Clavijo, Joana; García Gallastegui, Patricia; Khatib, Abdel Majid; Poschmann, Gereon; Stühler, Kai; Armesto, María; Lawrie, Charles; Badiola Echaburu, Iker; Araúzo Bravo, Marcos J. (MDPI, 2020-08-22)
      (1) Background & Aims: The roles of different cells in the tumor microenvironment (TME) are critical to the metastatic process. The phenotypic transformation of the liver cells is one of the most important stages of the ...
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      Antioxidant-Based Therapy Reduces Early-Stage Intestinal Ischemia-Reperfusion Injury in Rats 

      Gutiérrez Sánchez, Gaizka; García Alonso, Ignacio; Gutiérrez Sáenz de Santa María, Jorge; Alonso Varona, Ana Isabel; Herrero de la Parte, Borja (MDPI, 2021-05-27)
      Intestinal ischemia-reperfusion injury (i-IRI) is a rare disorder with a high mortality rate, resulting from the loss of blood flow to an intestinal segment. Most of the damage is triggered by the restoration of flow and ...
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      Aplicación de tecnologías disruptivas en telemedicina para la cobertura universal de servicios de salud 

      Galván, P.; Rivas, Ronald; Ortellado, José; Portillo, Juan; Mazzoleni, Julio; Hilario Rodríguez, Enrique (Instituto Nacional De Salud - MSP y BS, 2020-06)
      [ES] La aplicación de tecnologías disruptivas en telemedicina facilita la accesibilidad a tecnologías diagnósticas de poblaciones remotas sin acceso a especialistas y mejora la cobertura universal de servicios de salud. ...
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      Are environmental risk factors for current wheeze in the International Study of Asthma and Allergies in Childhood (ISAAC) phase three due to reverse causation? 

      ISAAC Phase Three Study Group; González Díaz, Carlos; Pérez-Yarza Pérez-Irezabal, Gorka (Wiley, 2019-04)
      Background: Phase Three of the International Study of Asthma and Allergies in Childhood (ISAAC) measured the global prevalence of symptoms of asthma in children. We undertook comprehensive analyses addressing risk factors ...
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      Associative Conditioning Is a Robust Systemic Behavior in Unicellular Organisms: An Interspecies Comparison 

      Carrasco-Pujante, Jose; Bringas Roldán, Carlos; Malaina Celada, Iker; Fedetz, Maria; Martínez Fernández, Luis; Pérez Yarza, Gorka; Boyano López, María Dolores; Berdieva, Mariia; Goodkov, Andrew; López, José I.; Knafo, Shira; Martínez de la Fuente Martínez, Ildefonso Abel (Frontiers Media, 2021-07-19)
      The capacity to learn new efficient systemic behavior is a fundamental issue of contemporary biology. We have recently observed, in a preliminary analysis, the emergence of conditioned behavior in some individual amoebae ...
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      BRAF V600E mutational load as a prognosis biomarker in malignant melanoma 

      Sevilla Mambrilla, Arrate; Morales González, María Celia; Ezcurra García Unzueta, Pilar Ariadna; Rasero, Javier; Velasco, Verónica; Cancho Galán, Goikoane; Sánchez Díez, Ana; Mujika, Karmele; Penas, Cristina; Smith Zubiaga, Isabel; Asumendi Mallea, Aintzane; Cortés Díaz, Jesús María; Boyano López, María Dolores; Alonso Alegre, Santos (Public Library Science, 2020-03-13)
      Analyzing the mutational load of driver mutations in melanoma could provide valuable information regarding its progression. We aimed at analyzing the heterogeneity of mutational load of BRAF V600E in biopsies of melanoma ...
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      Cannabinoid-mediated Modulation of Oxidative Stress and Early Inflammatory Response after Hypoxia–Ischemia 

      Alonso-Alconada, Daniel; Álvarez, Francisco José; Goñi de Cerio, Felipe; Hilario Rodríguez, Enrique; Álvarez Díaz, Antonia Ángeles (MDPI, 2020-02-14)
      In the process of neonatal encephalopathy, oxidative stress and neuroinflammation have a prominent role after perinatal asphyxia. With the exception of therapeutic hypothermia, no therapeutic interventions are available ...
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      Cell Reprogramming, IPS Limitations, and Overcoming Strategies in Dental Bioengineering 

      Ibarretxe Bilbao, Gaskon; Álvarez Díaz, Antonia Ángeles; Cañavate Escribano, María Luz; Hilario Rodríguez, Enrique; Aurrekoetxea Campo, Maitane; Unda Rodríguez, Fernando José (SAGE-Hindawi Access to Research, 2012-03-29)
      The procurement of induced pluripotent stem cells, or IPS cells, from adult differentiated animal cells has the potential to revolutionize future medicine, where reprogrammed IPS cells may be used to repair disease-affected ...
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      Cell-Centric View of Apoptosis and Apoptotic Cell Death-Inducing Antitumoral Strategies 

      Apraiz García, Aintzane; Boyano López, María Dolores; Asumendi Mallea, Aintzane (MDPI, 2011-03-03)
      Programmed cell death and especially apoptotic cell death, occurs under physiological conditions and is also desirable under pathological circumstances. However, the more we learn about cellular signaling cascades, the ...
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      Cellulose and Graphene Based Polyurethane Nanocomposites for FDM 3D Printing: Filament Properties and Printability 

      Larraza Arocena, Izaskun; Vadillo del Ser, Julen; Calvo Correas, Tamara; Tejado, Alvaro; Olza, Sheila; Peña Rodríguez, Cristina; Arbelaiz Garmendia, Aitor; Eceiza Mendiguren, María Aranzazu (MDPI, 2021-03-09)
      3D printing has exponentially grown in popularity due to the personalization of each printed part it offers, making it extremely beneficial for the very demanding biomedical industry. This technique has been extensively ...
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      Changes in Surface Tension of Aqueous Humor in Anterior Segment Ocular Pathologies 

      Cabrerizo Núñez, Francisco Javier; Urcola Carrera, Javier Haritz; Vecino Cordero, Elena (MDPI, 2016-09)
      The aim of this study was to identify and determine differences in surface tension (ST) of aqueous humor (AH) in patients with cataract, glaucoma and Fuchs endothelial dystrophy (FED). Two hundred and two samples of AH ...