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Never-resting microglia: physiological roles in the healthy brain and pathological implications
(Frontiers Research Foundation, 2014-08-15)
Microglia are largely known as the major orchestrators of the brain inflammatory response. As such, they have been traditionally studied in various contexts of disease, where their activation has been assumed to induce a ...
Radiotherapy plus nimotuzumab or placebo in the treatment of high grade glioma patients: results from a randomized, double blind trial
(BioMed Central, 2013-06-19)
Background
The prognosis of patients bearing high grade glioma remains dismal. Epidermal Growth Factor Receptor (EGFR) is well validated as a primary contributor of glioma initiation and progression. Nimotuzumab is a ...
Factors associated with chronic pain in patients with bipolar depression: a cross-sectional study
(BioMed Central, 2013-04-15)
Background: While pain is frequently associated with unipolar depression, few studies have investigated the link between pain and bipolar depression. In the present study we estimated the prevalence and characteristics of ...
Antioxidant defense system and family environment in adolescents with family history of psychosis
(BioMed Central, 2012-11-16)
[EN] Our objective was to determine antioxidant defence activity in healthy controls (HC) and healthy unaffected second-degree relatives of patients with early onset psychosis (HC-FHP),and to assess its relationship with ...
GABA release by hippocampal astrocytes
(Frontiers Res Found, 2012-08-17)
Astrocytes can directly influence neuronal activity through the release of various transmitters acting on membrane receptors expressed by neurons. However, in contrast to glutamate and ATP for instance, the release of GABA ...
Early astrocytic atrophy in the entorhinal cortex of a triple transgenic animal model of Alzheimer's disease
(Portland Press, 2011)
The EC (entorhinal cortex) is fundamental for cognitive and mnesic functions. Thus damage to this area appears as a key element in the progression of AD (Alzheimer's disease), resulting in memory deficits arising from ...
Unlike Physical Exercise, Modified Environment Increases the Lifespan of SOD1(G93A) Mice However Both Conditions Induce Cellular Changes
(Public Library of Science, 2012-09-20)
Background: Amyotrophic lateral sclerosis (ALS) is characterized by a gradual muscular paralysis resulting from progressive motoneurons death. ALS etiology remains unknown although it has been demonstrated to be a ...
Neurotransmitter signaling in the pathophysiology of microglia
(Frontiers Research Foundation, 2013)
Microglial cells are the resident immune cells of the central nervous system. In the resting state, microglia are highly dynamic and control the environment by rapidly extending and retracting motile processes. Microglia ...
Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis
(Frontiers Research Foundation, 2013-01)
Microglia are the resident brain macrophages and they have been traditionally studied as orchestrators of the brain inflammatory response during infections and disease. In addition, microglia has a more benign, less explored ...
Increased physical activity is not enough to recover astrocytic population from dark-rearing. Synergy with multisensory enrichment is required
(Frontiers Research Foundation, 2013-10-04)
Elimination of sensory inputs (deprivation) modifies the properties of the sensory cortex and serves as a model for studying plasticity during postnatal development. Many studies on the effects of deprivation have been ...