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Increased antiparkinson efficacy of the combined administration of VEGF- and GDNF-loaded nanospheres in a partial lesion model of Parkinson's disease

Herrán Martínez, Enara; Requejo Rodríguez, Catalina; Ruiz Ortega, José Ángel; Aristieta Arbelaiz, Asier; Igartua Olaechea, Manuela; Bengoetxea Odriozola, Harkaitz; Ugedo Urruela, Luisa; Pedraz Muñoz, José Luis; Lafuente Sánchez, José Vicente; Hernández Martín, Rosa María (Dove Medical Press, 2014)

Current research efforts are focused on the application of growth factors, such as glial cell line-derived neurotrophic factor (GDNF) and vascular endothelial growth factor (VEGF), as neuroregenerative approaches that will ...

Current Techniques for Investigating the Brain Extracellular Space

Soria Lannes, Federico Nicolás; Miguélez Palomo, Cristina; Peñagarikano Ahedo, Olga; Tonnesen, Jan (Frontiers Media, 2020-10-14)

The brain extracellular space (ECS) is a continuous reticular compartment that lies between the cells of the brain. It is vast in extent relative to its resident cells, yet, at the same time the nano- to micrometer dimensions ...

Changes in Day/Night Activity in the 6-OHDA-Induced Experimental Model of Parkinson’s Disease: Exploring Prodromal Biomarkers

Requejo Rodríguez, Catalina; López de Ipiña Peña, Miren Karmele; Ruiz Ortega, José Ángel; Fernández Gómez de Segura, Elsa; Calvo Salomón, Pilar María; Morera Herreras, Teresa; Miguélez Palomo, Cristina; Cardona Grifoll, Laura; Cepeda Berenguer, Hodei; Ugedo Urruela, Luisa; Lafuente Sánchez, José Vicente (Frontiers Media, 2020-10-14)

The search for experimental models mimicking an early stage of Parkinson's disease (PD) before motor manifestations is fundamental in order to explore early signs and get a better prognosis. Interestingly, our previous ...

Microglial Phagocytosis Dysfunction in the Dentate Gyrus is Related to Local Neuronal Activity in a Genetic Model of Epilepsy

Sierra Torre, Virginia; Plaza Zabala, Ainhoa; Bonifazi, Paolo; Abiega Etxabe, Oihane; Díaz Aparicio, Irune; Tegelberg, Saara; Lehesjoki, Anna Elina; Valero Gómez-Lobo, Jorge; Sierra Saavedra, Amanda (Wiley, 2020-11)

Objective Microglial phagocytosis of apoptotic cells is an essential component of the brain regenerative response during neurodegeneration. Whereas it is very efficient in physiological conditions, it is impaired in mouse ...

Dopaminergic Denervation Impairs Cortical Motor and Associative/Limbic Information Processing Through the Basal Ganglia and its Modulation by the CB1 Receptor

Antonazzo Soler, Mario; Gómez Urquijo, Sonia María; Ugedo Urruela, Luisa; Morera Herreras, Teresa (Academic Press, 2021-01)

The basal ganglia (BG) are involved in cognitive/motivational functions in addition to movement control. Thus, BG segregated circuits, the sensorimotor (SM) and medial prefrontal (mPF) circuits, process different functional ...

Assessing Autophagy in Microglia: A Two-Step Model to Determine Autophagosome Formation, Degradation, and Net Turnover

Plaza Zabala, Ainhoa; Sierra Torre, Virginia; Sierra Saavedra, Amanda (Frontiers Media, 2021-01-29)

Autophagy is a complex process that encompasses the enclosure of cytoplasmic debris or dysfunctional organelles in membranous vesicles, the autophagosomes, for their elimination in the lysosomes. Autophagy is increasingly ...

The Absence of the Transient Receptor Potential Vanilloid 1 Directly Impacts on the Expression and Localization of the Endocannabinoid System in the Mouse Hippocampus

Egaña Huguet, Jon; Bonilla del Río, Itziar; Gómez Urquijo, Sonia María; Mimenza Saiz, Amaia; Saumell Esnaola, Miquel; Borrega Román, Leire; García del Caño, Gontzal; Sallés Alvira, Joan; Puente Bustinza, Nagore; Gerrikagoitia Marina, Inmaculada; Elezgarai Gabantxo, Izaskun; Grandes Moreno, Pedro Rolando (Frontiers Media, 2021-02-22)

The transient receptor potential vanilloid 1 (TRPV1) is a non-selective ligand-gated cation channel involved in synaptic transmission, plasticity, and brain pathology. In the hippocampal dentate gyrus, TRPV1 localizes to ...

The Effect of 5-HT1A Receptor Agonists on the Entopeduncular Nucleus is Modified in 6-Hydroxydopamine-Lesioned Rats

Vegas Suárez, Sergio; Aristieta Arbelaiz, Asier; Requejo Rodríguez, Catalina; Bengoetxea Odriozola, Harkaitz; Lafuente Sánchez, José Vicente; Miguélez Palomo, Cristina; Ugedo Urruela, Luisa (Wiley, 2021-06)

Background and Purpose l-DOPA prolonged treatment leads to disabling motor complications as dyskinesia that could be decreased by drugs acting on 5-HT1A receptors. Since the internal segment of the globus pallidus, homologous ...

Effects of Platelet-Rich Plasma on Cellular Populations of the Central Nervous System: The Influence of Donor Age

Delgado San Vicente, Diego; Bilbao, Ane Miren; Beitia San Vicente, Maider; Garate, Ane; Sánchez, Pello; González Burguera, Imanol; Isasti, Amaia; López de Jesús, Maider; Zuazo Ibarra, Jone; Montilla López, Alejandro; Domercq García, María; Capetillo González de Zarate, Estibaliz; García del Caño, Gontzal; Sallés Alvira, Joan; Matute Almau, Carlos José; Sánchez, Mikel (MDPI, 2021-02-09)

first_page settings Open AccessArticle Effects of Platelet-Rich Plasma on Cellular Populations of the Central Nervous System: The Influence of Donor Age by Diego Delgado 1, Ane Miren Bilbao 2, Maider Beitia 1, Ane ...

Lack of the transient receptor potential vanilloid 1 shifts cannabinoid-dependent excitatory synaptic plasticity in the dentate gyrus of the mouse brain hippocampus

Egaña Huguet, Jon; Saumell Esnaola, Miquel; Achicallende Urcaregui, Svein; Soria Gómez, Edgar; Bonilla del Río, Itziar; García del Caño, Gontzal; Barrondo Lacarra, Sergio; Sallés Alvira, Joan; Gerrikagoitia Marina, Inmaculada; Puente Bustinza, Nagore; Elezgarai Gabantxo, Izaskun; Grandes Moreno, Pedro Rolando (Frontiers Media, 2021-07-07)

[EN] The transient receptor potential vanilloid 1 (TRPV1) participates in synaptic functions in the brain. In the dentate gyrus, post-synaptic TRPV1 in the granule cell (GC) dendritic spines mediates a type of long-term ...