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Now showing items 11-20 of 109
Long-acting injectable aripiprazole in pregnant women with schizophrenia: a case-series report
(Sage, 2021-01)
Antipsychotic long-acting formulations (LAI-AP) have emerged as a new therapeutic choice to treat patients presenting a severe mental disorder. Despite that, to date, there is a lack of safety data and studies regarding ...
Longitudinal Evaluation of a Novel BChE PET Tracer as An Early In Vivo Biomarker in the Brain of a Mouse Model for Alzheimer Disease
(Ivyspring International Publisher, 2021-04-26)
Purpose: The increase in butyrylcholinesterase (BChE) activity in the brain of Alzheimer disease (AD) patients and animal models of AD position this enzyme as a potential biomarker of the disease. However, the information ...
Editorial: Assessing Microglial Function and Identity
(Frontiers Media, 2021-12-20)
Dermic-derived fibroblasts for the study of amyotrophic lateral sclerosis
(Wolters Kluwer - Medknow, 2020-11)
Impact of social and mobility restrictions in Parkinson's disease during COVID-19 lockdown
(Springer, 2021-08-30)
Background The consequences of strict COVID-19 mobility restrictions on motor/non-motor features in Parkinson's disease (PD) have not been systematically studied but worse mobility and quality of life have been reported. ...
Patient-Specific iPSC-Derived Cellular Models of LGMDR1
(Elsevier, 2021-04-08)
Limb-girdle muscular dystrophy recessive 1 (LGMDR1) represents one of the most common types of LGMD in the population, where patients develop a progressive muscle degeneration. The disease is caused by mutations in calpain ...
Non-Pharmacological Strategies for Self-Directed and Interpersonal Violence in People with Severe Mental Illness: a Rapid Overview of Systematic Reviews
(BMJ Publishing Group, 2021)
Introduction Self-directed and interpersonal violence among people with severe mental illness has become a health priority. Though non-pharmacological interventions have been investigated, to our knowledge, no summary of ...
Common Variants in Alzheimer’s Disease and Risk Stratification by Polygenic Risk Scores
(Springer, 2021-06-07)
Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical ...
Preclinical characterization of antagomiR-218 as a potential treatment for myotonic dystrophy
(Elsevier, 2021-12-03)
Myotonic dystrophy type 1 (DM1) is a rare neuromuscular disease caused by expansion of unstable CTG repeats in a non-coding region of the DMPK gene. CUG expansions in mutant DMPK transcripts sequester MBNL1 proteins in ...
Quantifying the patients perspective in neuromyelitis optica spectrum disorder: Psychometric properties of the SymptoMScreen questionnaire
(Public Library Of Science, 2021-07-29)
BACKGROUND: The assessment of self-reported outcomes in neuromyelitis optica spectrum disorder (NMOSD) is limited by the lack of validated disease-specific measures. The SymptoMScreen (SyMS) is a patient-reported questionnaire ...