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Circadian glucocorticoid oscillations preserve a population of adult hippocampal neural stem cells in the aging brain
(Springer, 2019-06-20)
A decrease in adult hippocampal neurogenesis has been linked to age-related cognitive impairment. However, the mechanisms involved in this age-related reduction remain elusive. Glucocorticoid hormones (GC) are important ...
Phenotypical and functional heterogeneity of neural stem cells in the aged hippocampus
(Wiley, 2019-08)
Adult neurogenesis persists in the hippocampus of most mammal species during postnatal and adult life, including humans, although it declines markedly with age. The mechanisms driving the age-dependent decline of hippocampal ...
Disruption of Oligodendrocyte Progenitor Cells is an Early Sign of Pathology in the Triple Transgenic Mouse Model of Alzheimer's Disease
(Elsevier, 2020-10)
There is increasing evidence that myelin disruption is related to cognitive decline in Alzheimer's disease (AD). In the CNS, myelin is produced by oligodendrocytes, which are generated throughout life by adult oligodendrocyte ...
Radiotherapy plus nimotuzumab or placebo in the treatment of high grade glioma patients: results from a randomized, double blind trial
Solomón, María Teresa; Selva, Julio César; Figueredo, Javier; Vaquer, José; Toledo, Carolina; Quintanal, Nelson; Salva, Silvia; Domínguez, Rafael; Alert, José; Marinello, Jorge Juan; Catalá, Mauricio; González Griego, Martha; Martell, Juan Antonio; Lorenzo Luaces, Patricia; Ballesteros Rodríguez, Francisco Javier 
; De Castro, Niurys; Bach, Ferdinand; Crombet, Tania (BioMed Central, 2013-06-19)
; De Castro, Niurys; Bach, Ferdinand; Crombet, Tania (BioMed Central, 2013-06-19)
Background
The prognosis of patients bearing high grade glioma remains dismal. Epidermal Growth Factor Receptor (EGFR) is well validated as a primary contributor of glioma initiation and progression. Nimotuzumab is a ...
Early Functional Deficit and Microglial Disturbances in a Mouse Model of Amyotrophic Lateral Sclerosis
(Public Library of Science, 2012-04-25)
Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by selective motoneurons degeneration. There is today no clear-cut pathogenesis sequence nor any treatment. However growing ...
Autophagic Marker MAP1LC3B Expression Levels Are Associated with Carotid Atherosclerosis Symptomatology
(Public Library Science, 2014-12-12)
Objectives: The mechanism by which atheroma plaque becomes unstable is not completely understood to date but analysis of differentially expressed genes in stable versus unstable plaques may provide clues. This will be ...
Is there a subgroup of long-term evolution among patients with advanced lung cancer?: Hints from the analysis of survival curves from cancer registry data
Sánchez, Lizet; Lorenzo-Luaces, Patricia; Viada, Carmen; Galán, Yaima; Ballesteros Rodríguez, Francisco Javier ; Crombet, Tania; Lage, Agustín (Biomed Central, 2014-12-11)
; Crombet, Tania; Lage, Agustín (Biomed Central, 2014-12-11)
Background: Recently, with the access of low toxicity biological and targeted therapies, evidence of the existence of a long-term survival subpopulation of cancer patients is appearing. We have studied an unselected ...
Human Endogenous Retrovirus HERV-Fc1 Association with Multiple Sclerosis Susceptibility: A Meta-Analysis
(Public Library Science, 2014-03-03)
Background: Human endogenous retroviruses (HERVs) are repetitive sequences derived from ancestral germ-line infections by exogenous retroviruses and different HERV families have been integrated in the genome. HERV-Fc1 in ...
Muscle wasting in myotonic dystrophies: a model of premature aging
(Frontiers Research Foundation, 2015-07-09)
Myotonic dystrophy type 1 (DM1 or Steinert's disease) and type 2 (DM2) are multisystem disorders of genetic origin. Progressive muscular weakness, atrophy and myotonia are the most prominent neuromuscular features of these ...
Longitudinal evaluation of neuroinflammation and oxidative stress in a mouse model of Alzheimer disease using positron emission tomography
; ; ; ; ; ; ; ; ; ; ; ; ; Llop Roig, Jordi (BMC, 2022)
(BMC, 2022)
[EN] Background: Validation of new biomarkers of Alzheimer disease (AD) is crucial for the successful development and implementation of treatment strategies. Additional to traditional AT(N) biomarkers, neuroinflammation ...