dc.contributor.author | Geisel, Nico | |
dc.contributor.author | Vilar, José M. G. | |
dc.contributor.author | Rubi, Miguel | |
dc.date.accessioned | 2011-05-31T17:10:14Z | |
dc.date.available | 2011-05-31T17:10:14Z | |
dc.date.issued | 2011-04-15 | |
dc.identifier.citation | PLoS ONE 6(4) : (2011) // e18622 | es |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | http://hdl.handle.net/10810/2689 | |
dc.description | 11 p. | es |
dc.description.abstract | Bacteria spend most of their lifetime in non-growing states which allow them to survive extended periods of stress and starvation. When environments improve, they must quickly resume growth to maximize their share of limited nutrients. Cells with higher stress resistance often survive longer stress durations at the cost of needing more time to resume growth, a strong disadvantage in competitive environments. Here we analyze the basis of optimal strategies that microorganisms can use to cope with this tradeoff. We explicitly show that the prototypical inverse relation between stress resistance and growth rate can explain much of the different types of behavior observed in stressed microbial populations. Using analytical mathematical methods, we determine the environmental parameters that decide whether cells should remain vegetative upon stress exposure, downregulate their metabolism to an intermediate optimum level, or become dormant. We find that cell-cell variability, or intercellular noise, is consistently beneficial in the presence of extreme environmental fluctuations, and that it provides an efficient population-level mechanism for adaption in a deteriorating environment. Our results reveal key novel aspects of responsive phenotype switching and its role as an adaptive strategy in changing environments. | es |
dc.description.sponsorship | This work was partially supported by the Spanish Ministry of Education grant no. FPU AP-2007-00975 and the Spanish Ministry of Science grant no. FIS 2008-04386. Nico Geisel would like to thank Matthias Kaschube for financial support. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | es |
dc.language.iso | eng | es |
dc.publisher | Public Library of Science | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | vibrio SP S14 | es |
dc.subject | escherichia coli | es |
dc.subject | bacterial persistence | es |
dc.subject | changing environments | es |
dc.subject | gene expression | es |
dc.subject | stress response | es |
dc.subject | cell cycle | es |
dc.subject | starvation | es |
dc.subject | survival | es |
dc.subject | protein | es |
dc.title | Optimal Resting-Growth Strategies of Microbial Populations in Fluctuating Environments | es |
dc.type | info:eu-repo/semantics/article | es |
dc.rights.holder | © 2011 Geisel et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | es |
dc.relation.publisherversion | http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0018622 | es |
dc.identifier.doi | 10.1371/journal.pone.0018622 | |
dc.departamentoes | Bioquímica y biología molecular | es_ES |
dc.departamentoeu | Biokimika eta biologia molekularra | es_ES |
dc.subject.categoria | AGRICULTURAL AND BIOLOGICAL SCIENCES | |
dc.subject.categoria | MEDICINE | |
dc.subject.categoria | BIOCHEMISTRY AND MOLECULAR BIOLOGY | |