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dc.contributor.authorAmaro, Luís
dc.contributor.authorCorreia, Daniela M.
dc.contributor.authorMarques-Almeida, Teresa
dc.contributor.authorMartins, Pedro M.
dc.contributor.authorPérez Álvarez, Leyre
dc.contributor.authorVilas Vilela, José Luis ORCID
dc.contributor.authorBotelho, Gabriela
dc.contributor.authorLanceros Méndez, Senentxu
dc.contributor.authorRibeiro, Clarisse
dc.date.accessioned2018-11-15T13:30:44Z
dc.date.available2018-11-15T13:30:44Z
dc.date.issued2018-08
dc.identifier.citationInternational Journal of Molecular Sciences 19(8) : (2018) // Article ID 2149es_ES
dc.identifier.issn1422-0067
dc.identifier.urihttp://hdl.handle.net/10810/29676
dc.description.abstractPolymer-based piezoelectric biomaterials have already proven their relevance for tissue engineering applications. Furthermore, the morphology of the scaffolds plays also an important role in cell proliferation and differentiation. The present work reports on poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV), a biocompatible, biodegradable, and piezoelectric biopolymer that has been processed in different morphologies, including films, fibers, microspheres, and 3D scaffolds. The corresponding magnetically active PHBV-based composites were also produced. The effect of the morphology on physico-chemical, thermal, magnetic, and mechanical properties of pristine and composite samples was evaluated, as well as their cytotoxicity. It was observed that the morphology does not strongly affect the properties of the pristine samples but the introduction of cobalt ferrites induces changes in the degree of crystallinity that could affect the applicability of prepared biomaterials. Young's modulus is dependent of the morphology and also increases with the addition of cobalt ferrites. Both pristine and PHBV/cobalt ferrite composite samples are not cytotoxic, indicating their suitability for tissue engineering applications.es_ES
dc.description.sponsorshipThe authors thank the FCT (Fundacao para a Ciencia e Tecnologia) for financial support under the framework of strategic funding UID/FIS/04650/2013, UID/QUI/00686/2013, and UID/QUI/0686/2016; project PTDC/EEI-SII/5582/2014; and project POCI-01-0145-FEDER-028237. Funds provided by FCT in the framework of EuroNanoMed 2016 call, Project LungChek ENMed/0049/2016 are also gratefully acknowledged. D.M.C. and C.R. also thank the FCT for the grants SFRH/BPD/121526/2016 and SFRH/BPD/90870/2012, respectively. Finally, the authors acknowledge funding by the Spanish Ministry of Economy and Competitiveness (MINECO) through the project MAT2016-76039-C4-3-R (AEI/FEDER, UE) and from the Basque Government Industry Department under the ELKARTEK and HAZITEK program.es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/MAT2016-76039-C4-3-Res_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectbiomaterialses_ES
dc.subjectcobalt ferriteses_ES
dc.subjectpoly(hydroxybutyrate-co-hydroxyvalerate)es_ES
dc.subjecttissue engineeringes_ES
dc.subjectpoly(vinylidene fluoride)es_ES
dc.subjectmechanical-propertieses_ES
dc.subjectbiomimetic materialses_ES
dc.subjectfiber orientationes_ES
dc.subjectstem-cellses_ES
dc.subjectscaffoldses_ES
dc.subjectbiomaterialses_ES
dc.subjectstrategieses_ES
dc.subjectpolymerses_ES
dc.subjectmatses_ES
dc.titleTailored Biodegradable and Electroactive Poly(Hydroxybutyrate-Co-Hydroxyvalerate) Based Morphologies for Tissue Engineering Applicationses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holder© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).es_ES
dc.rights.holderAtribución 3.0 España*
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/19/8/2149es_ES
dc.identifier.doi10.3390/ijms19082149
dc.departamentoesQuímica físicaes_ES
dc.departamentoeuKimika fisikoaes_ES


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© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Except where otherwise noted, this item's license is described as © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).