Seafood Consumption, Omega-3 Fatty Acids Intake, and Life-Time Prevalence of Depression in the PREDIMED-Plus Trial
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Date
2018-12Author
Sánchez Villegas, Almudena
Álvarez Pérez, Jacqueline
Toledo, Estefanía
Salas Salvadó, Jordi
Ortega Azorín, Carolina
Zomeño Fajardo, María Dolores
Vioque, Jesús
Martínez, José Alfredo
Romaguera, Dora
Pérez López, Jessica
López Miranda, José
Estruch, Ramón
Bueno Cavanillas, Aurora
Arós Borau, Luis Fernando
Tur, Josep A.
Tinahones, Francisco J.
Lecea, Oscar
Martín, Vicente
Ortega Calvo, M.
Vázquez, Clotilde
Pintó, Xavier
Vidal, Josep
Daimiel, Lidia
Delgado Rodríguez, Miguel
Matía Martín, Pilar
Corella, Dolores
Díaz López, Andrés
Babio, Nancy
Muñoz, Miguel Ángel
Fitó, Montserrat
García de la Hera, Manoli
Abete, Itziar
García Ríos, Antonio
Ros, Emilio
Ruíz Canela, Miguel
Martínez González, Miguel Ángel
Izquierdo, Marisol
Serra Majem, Lluís
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Nutrients 10(12) : (2018) // Article ID 2000
Abstract
BACKGROUND: The aim of this analysis was to ascertain the type of relationship between fish and seafood consumption, omega-3 polyunsaturated fatty acids (omega-3 PUFA) intake, and depression prevalence.
METHODS: Cross-sectional analyses of the PREDIMED-Plus trial. Fish and seafood consumption and omega-3 PUFA intake were assessed through a validated food-frequency questionnaire. Self-reported life-time medical diagnosis of depression or use of antidepressants was considered as outcome. Depressive symptoms were collected by the Beck Depression Inventory-II. Logistic regression models were used to estimate the association between seafood products and omega-3 PUFA consumption and depression. Multiple linear regression models were fitted to assess the association between fish and long-chain (LC) omega-3 PUFA intake and depressive symptoms.
RESULTS: Out of 6587 participants, there were 1367 cases of depression. Total seafood consumption was not associated with depression. The odds ratios (ORs) (95% confidence intervals (CIs)) for the 2nd, 3rd, and 4th quintiles of consumption of fatty fish were 0.77 (0.63⁻0.94), 0.71 (0.58⁻0.87), and 0.78 (0.64⁻0.96), respectively, and p for trend = 0.759. Moderate intake of total LC omega-3 PUFA (approximately 0.5⁻1 g/day) was significantly associated with a lower prevalence of depression.
CONCLUSION: In our study, moderate fish and LC omega-3 PUFA intake, but not high intake, was associated with lower odds of depression suggesting a U-shaped relationship.