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dc.contributor.authorOrtiz de Elguea Flecha, Verónica
dc.contributor.authorCarral Menoyo, Asier
dc.contributor.authorSimón Vidal, Lorena
dc.contributor.authorMartínez Nunes, Mikel
dc.contributor.authorBarbolla Cuadrado, Iratxe
dc.contributor.authorLete, Marta G.
dc.contributor.authorSotomayor Anduiza, María Nuria
dc.contributor.authorLete Expósito, María Esther
dc.date.accessioned2021-11-29T08:46:30Z
dc.date.available2021-11-29T08:46:30Z
dc.date.issued2021-11-09
dc.identifier.citationACS Omega 6(44) : 29483-29494 (2021)es_ES
dc.identifier.issn2470-1343
dc.identifier.urihttp://hdl.handle.net/10810/54159
dc.description.abstract[EN]Highly substituted coumarins, privileged and versatile scaffolds for bioactive natural products and fluorescence imaging, are obtained via a Pd(II)-catalyzed direct C–H alkenylation reaction (Fujiwara–Moritani reaction), which has emerged as a powerful tool for the construction and functionalization of heterocyclic compounds because of its chemical versatility and its environmental advantages. Thus, a selective 6-endo cyclization led to 4-substituted coumarins in moderate yields. Selected examples have been further functionalized in C3 through a second intermolecular C–H alkenylation reaction to give coumarin-acrylate hybrids, whose fluorescence spectra have been measured.es_ES
dc.description.sponsorshipMinisterio de Economía y Competitividad (FEDER CTQ2016-74881-P), Ministerio de Ciencia e Innovación (PID2019-104148GB-I00), and Gobierno Vasco (IT1045-16) are gratefully acknowledged for their financial support. A.C.-M. wishes to thank Gobierno Vasco for a grant. Technical and human support provided by Servicios Generales de Investigación SGIker (UPV/EHU, MINECO, GV/EJ, ERDF and ESF) is also acknowledged.es_ES
dc.language.isoenges_ES
dc.publisherAmerican Chemical Societyes_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/CTQ2016-74881-Pes_ES
dc.relationinfo:eu-repo/grantAgreement/MICINN/PID2019-104148GB-I00es_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectaromatic compoundses_ES
dc.subjectorganic compoundses_ES
dc.subjectorganic reactionses_ES
dc.titlePd(II)-Catalyzed Fujiwara-Moritani Reactions for the Synthesis and Functionalization of Substituted Coumarins.es_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holder© 2021 The Authors. Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)es_ES
dc.rights.holderAtribución-NoComercial-SinDerivadas 3.0 España*
dc.relation.publisherversionhttps://pubs.acs.org/doi/10.1021/acsomega.1c03469es_ES
dc.identifier.doi10.1021/acsomega.1c03469
dc.departamentoesQuímica Orgánica e Inorgánicaes_ES
dc.departamentoeuKimika Organikoa eta Ez-Organikoaes_ES


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© 2021 The Authors. Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Except where otherwise noted, this item's license is described as © 2021 The Authors. Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)