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dc.contributor.authorOrtiz de Elguea Flecha, Verónica
dc.contributor.authorCarral Menoyo, Asier
dc.contributor.authorSimón Vidal, Lorena
dc.contributor.authorMartínez Nunes, Mikel
dc.contributor.authorBarbolla Cuadrado, Iratxe
dc.contributor.authorLete, Marta G.
dc.contributor.authorSotomayor Anduiza, María Nuria
dc.contributor.authorLete Expósito, María Esther
dc.identifier.citationACS Omega 6(44) : 29483-29494 (2021)es_ES
dc.description.abstract[EN]Highly substituted coumarins, privileged and versatile scaffolds for bioactive natural products and fluorescence imaging, are obtained via a Pd(II)-catalyzed direct C–H alkenylation reaction (Fujiwara–Moritani reaction), which has emerged as a powerful tool for the construction and functionalization of heterocyclic compounds because of its chemical versatility and its environmental advantages. Thus, a selective 6-endo cyclization led to 4-substituted coumarins in moderate yields. Selected examples have been further functionalized in C3 through a second intermolecular C–H alkenylation reaction to give coumarin-acrylate hybrids, whose fluorescence spectra have been measured.es_ES
dc.description.sponsorshipMinisterio de Economía y Competitividad (FEDER CTQ2016-74881-P), Ministerio de Ciencia e Innovación (PID2019-104148GB-I00), and Gobierno Vasco (IT1045-16) are gratefully acknowledged for their financial support. A.C.-M. wishes to thank Gobierno Vasco for a grant. Technical and human support provided by Servicios Generales de Investigación SGIker (UPV/EHU, MINECO, GV/EJ, ERDF and ESF) is also acknowledged.es_ES
dc.publisherAmerican Chemical Societyes_ES
dc.subjectaromatic compoundses_ES
dc.subjectorganic compoundses_ES
dc.subjectorganic reactionses_ES
dc.titlePd(II)-Catalyzed Fujiwara-Moritani Reactions for the Synthesis and Functionalization of Substituted Coumarins.es_ES
dc.rights.holder© 2021 The Authors. Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)es_ES
dc.rights.holderAtribución-NoComercial-SinDerivadas 3.0 España*
dc.departamentoesQuímica Orgánica e Inorgánicaes_ES
dc.departamentoeuKimika Organikoa eta Ez-Organikoaes_ES

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© 2021 The Authors. Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Except where otherwise noted, this item's license is described as © 2021 The Authors. Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)