Outcomes associated with different vaccines in individuals with bipolar disorder and impact on the current COVID-19 pandemic- a systematic review
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Date
2022-01Author
Reininghaus, Eva Z.
Manchia, Mirko
Dalkner, Nina
Bonkat, Nina
Squassina, Alessio
Hodl, Isabel
Vieta, Eduard
Reif, Andreas
Hajek, Tomas
Landén, Mikael
Correll, Christoph U.
Scott, Jan
Etain, Bruno
Rietschel, Marcella
Bergink, Veerle
Kessing, Lars Vedel
Fagiolini, Andrea
Bauer, Michael
Goodwin, Guy M.
Kupka, Ralph
Schulze, Thomas G.
Lagerberg, Trine V.
Yildiz, Aysegul
Henry, Chantal
Morken, Gunnar
Ritter, Philipp
Nielsen, René E.
Licht, Rasmus W.
Bechdolf, Andreas
Andreassen, Ole A.
Fellendorf, Frederike Tabea
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European Neuropsychopharmacology 54 : 90-99 (2022)
Abstract
[EN] Bipolar disorder (BD) might be associated with higher infection rates of coronavirus disease (COVID-19) which in turn could result in worsening the clinical course and outcome. This may be due to a high prevalence of somatic comorbidities and an increased risk of delays in and poorer treatment of somatic disease in patients with severe mental illness in general. Vaccination is the most important public health intervention to tackle the ongoing pandemic. We undertook a systematic review regarding the data on vaccinations in individuals with BD. Proportion of prevalence rates, efficacy and specific side effects of vaccinations and in individuals with BD were searched. Results show that only five studies have investigated vaccinations in individuals with BD, which substantially limits the interpretation of overall findings. Studies on antibody production after vaccinations in BD are very limited and results are inconsistent. Also, the evidence-based science on side effects of vaccinations in individuals with BD so far is poor.