Optimizing antibiotic therapy for stenotrophomonas maltophilia infections in critically Ill patients: A pharmacokinetic/pharmacodynamic approach
dc.contributor.author | Barrasa González, Helena | |
dc.contributor.author | Morán Rodríguez, Miguel Ángel | |
dc.contributor.author | Fernández Ciriza, Leire | |
dc.contributor.author | Isla Ruiz, Arantxazu ![]() | |
dc.contributor.author | Solinís Aspiazu, María Ángeles ![]() | |
dc.contributor.author | Canut Blasco, Andrés | |
dc.contributor.author | Rodríguez Gascón, Alicia | |
dc.date.accessioned | 2024-06-27T17:30:25Z | |
dc.date.available | 2024-06-27T17:30:25Z | |
dc.date.issued | 2024-06-13 | |
dc.identifier.citation | Antibiotics 13(6) : (2024) // Article ID 553 | es_ES |
dc.identifier.issn | 2079-6382 | |
dc.identifier.uri | http://hdl.handle.net/10810/68696 | |
dc.description.abstract | Stenotrophomonas maltophilia is an opportunistic, multidrug-resistant non-fermentative Gram-negative bacillus, posing a significant challenge in clinical treatment due to its numerous intrinsic and acquired resistance mechanisms. This study aimed to evaluate the adequacy of antibiotics used for the treatment of S. maltophilia infections in critically ill patients using a pharmacokinetic/pharmacodynamic (PK/PD) approach. The antibiotics studied included cotrimoxazole, levofloxacin, minocycline, tigecycline, cefiderocol, and the new combination aztreonam/avibactam, which is not yet approved. By Monte Carlo simulations, the probability of target attainment (PTA), the PK/PD breakpoints, and the cumulative fraction of response (CFR) were estimated. PK parameters and MIC distributions were sourced from the literature, the European Committee on Antimicrobial Susceptibility Testing (EUCAST), and the SENTRY Antimicrobial Surveillance Program collection. Cefiderocol 2 g q8h, minocycline 200 mg q12h, tigecycline 100 mg q12h, and aztreonam/avibactam 1500/500 mg q6h were the best options to treat empirically infections due to S. maltophilia. Cotrimoxazole provided a higher probability of treatment success for the U.S. isolates than for European isolates. For all antibiotics, discrepancies between the PK/PD breakpoints and the clinical breakpoints defined by EUCAST (or the ECOFF) and CLSI were detected. | es_ES |
dc.description.sponsorship | This research was funded by the Basque Government (IT1587-22). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/es/ | |
dc.subject | Stenotrophomonas maltophilia | es_ES |
dc.subject | PK/PD | es_ES |
dc.subject | cotrimoxazole | es_ES |
dc.subject | levofloxacin | es_ES |
dc.subject | minocycline | es_ES |
dc.subject | tigecycline | es_ES |
dc.subject | aztreonam/avibactam | es_ES |
dc.subject | cefiderocol | es_ES |
dc.title | Optimizing antibiotic therapy for stenotrophomonas maltophilia infections in critically Ill patients: A pharmacokinetic/pharmacodynamic approach | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2024-06-26T13:24:18Z | |
dc.rights.holder | © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/2079-6382/13/6/553 | es_ES |
dc.identifier.doi | 10.3390/antibiotics13060553 | |
dc.departamentoes | Farmacia y ciencias de los alimentos | |
dc.departamentoeu | Farmazia eta elikagaien zientziak |
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Except where otherwise noted, this item's license is described as © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/).