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Long Interleukin-22 Binding Protein Isoform-1 Is an Intracellular Activator of the Unfolded Protein Response
(Frontiers Media, 2018-12-14)
The human IL22RA2 gene co-produces three protein isoforms in dendritic cells [IL-22 binding protein isoform-1 (IL-22BPi1), IL-22BPi2, and IL-22BPi3]. Two of these, IL-22BPi2 and IL-22BPi3, are capable of neutralizing the ...
Chronic Migraine Is a Misnomer
(Elsevier, 2017-05)
las lesiones son extensas o la sintomatología es muy intensase prefiere tratamiento quirúrgico8. En el caso de nuestrapaciente, el tratamiento con amitriptilina y diversos fárma-cos neuromoduladores solamente redujo de ...
Expression Profiling Analysis Reveals Key MicroRNA– mRNA Interactions in Early Retinal Degeneration in Retinitis Pigmentosa
Anasagasti, Ander; Ezquerra-Inchausti, Maitane; Barandika, Olatz; Muñoz-Culla, Maider 
; Caffarel, María M.; Otaegui Bichot, David; López de Munain Arregui, Adolfo José; Ruiz-Ederra, Javier (Association Research Vision Ophthalmology, 2018-05)
; Caffarel, María M.; Otaegui Bichot, David; López de Munain Arregui, Adolfo José; Ruiz-Ederra, Javier (Association Research Vision Ophthalmology, 2018-05)
PURPOSE. The aim of this study was to identify differentially expressed microRNAs (miRNAs) that might play an important role in the etiology of retinal degeneration in a genetic mouse model of retinitis pigmentosa (rd10 ...
Biomarcadores diagnósticos y de deterioro cognitivo en la enfermedad de Parkinson
(2017-09-14)
La enfermedad de Parkinson es una enfermedad neurodegenerativa en la que, como en otras, el proceso fisiopatológico que conduce a la muerte de neuronas está presente desde tiempo antes del diagnóstico. Las manifestaciones ...
Calpain 3 in skeletal muscle regeneration: Potential role in satellite cells and in the myogenic differentiation of iPSC-derived muscle progenitors
(2017-12-18)
La distrofia de cinturas de tipo 2A (LGMD2A) es una enfermedad genética de herencia autosómicarecesiva, causada por mutaciones en el gen CAPN3, que codifica la proteasa muscular no lisosomalcalpaína 3. Los pacientes sufren ...
Oxidative Stress and Proinflammatory Cytokines Contribute to Demyelination and Axonal Damage in a Cerebellar Culture Model of Neuroinflammation
(Public Library of Science, 2013-02-19)
Background: Demyelination and axonal damage are critical processes in the pathogenesis of multiple sclerosis (MS). Oxidative stress and pro-inflammatory cytokines elicited by inflammation mediates tissue damage.
Metho ...
Dbx1-Derived Pyramidal Neurons Are Generated Locally in the Developing Murine Neocortex
(Frontiers Media, 2018-10-31)
The neocortex (NCx) generates at the dorsal region of the pallium in the forebrain. Several adjacent structures also contribute with neurons to NCx. Ventral pallium (VP) is considered to generate several populations of ...
APP depletion alters selective pre- and post-synaptic proteins
(Elsevier, 2019-03)
The normal role of Alzheimer's disease (AD)-linked amyloid precursor protein (APP) in the brain remains incompletely understood. Previous studies have reported that lack of APP has detrimental effects on spines and ...
Spinal cord injury induces astroglial conversion towards neuronal lineage
(Biomed Central, 2016-10-06)
Background: Neurons have intrinsic capability to regenerate after lesion, though not spontaneously. Spinal cord injury (SCI) causes permanent neurological impairments partly due to formation of a glial scar that is composed ...
Co-administration of Anti microRNA-124 and -137 Oligonucleotides Prevents Hippocampal Neural Stem Cell Loss Upon Non-convulsive Seizures
(Frontiers Media, 2019-02-19)
Convulsive seizures promote adult hippocampal neurogenesis (AHN) through a transient activation of neural stem/progenitor cells (NSPCs) in the subgranular zone (SGZ) of the dentate gyrus (DG). However, in a significant ...