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The allosteric control mechanisms of alpha-glucan biosynthesis in bacteria
(2023-10-03)
{EN]The alpha-glucans, polysaccharides made of repetitive units of glucose, play a role as energy storage, as with intracellular glycogen, or as structural components, as with the capsular alpha-glucans surrounding the ...
Lipid regulation of Atg8 family protein recruitment and membrane modulation of mitophagy and autophagic cell death
(2017-01-20)
Tesi lan honen aurkikuntzek, mitofagian zehar LC3/GABARAP familiako proteinen mitokondrioetarako errekrutatze-prozesuaren mekanismo molekularraren eta Atg8 proteinaren giza ortologoek giza lerro zelular ezberdinetan daukaten ...
Mechanism for ESCPE-1 mediated membrane remodelling and cargo selection in endosomal
(2020-10-02)
El reciclaje de proteínas es fundamental para mantener la homeostasis celular. Este trabajo se enfoca en el reciclaje de proteínas que llegan a los endosomas. Allí, las proteínas transmembrana (receptores) son recicladas ...
Synthesis and evaluation of polymer-based nanocarriers for siRNA delivery
(2023-11-30)
El Siglo XX se han logrado importantes avances en la investigación de esta novedosa área, con el objetivo de trasladar a la clínica nuevas terapias basadas en RNAi. El ARN pequeño de interferencia (siRNA, por sus siglas ...
Interaction of the LC3/GABARAP autophagy proteins with membranes: Exploring the effects of ceramide
(2023-07-21)
La macroautofagia es un proceso que ocurre en los organismos eucariotas, se caracteriza por la formación del autofagosoma, una estructura de doble membrana encargada de rodear los componentes celulares que se degradan ...
Regulation of cell proliferation and migration by phosphatidic acid and ceramide 1-phosphate. Implication in lung cancer and inflammation
(2023-12-18)
According to the World Health Organization (WHO), chronic inflammatory lung diseases, includingasthma, COPD, fibrosis, or lung cancer are among the major causes of death Worldwide. Althoughthese are subjects of intense ...
Study of human and mouse dermal fibroblast heterogeneity by single-cell RNA sequencing.
(2023-10-18)
The skin is a complex vital organ composed of several layers. The middle layer, the dermis, is mainly composed of fibroblasts that produce the extracellular matrix (ECM) providing structural support. Recent research using ...
Regulation of macrophage and preadipocyte proliferation and migration by C1P
(2022-03-25)
Chronic inflammatory diseases are the most significant cause of death in the world. Indeed, according to the World Health Organization (WHO), 3 out of 5 people die due to chronic inflammatory diseases such as stroke, chronic ...
Development and integration of In Silico and In Vitro tools for comprehensive prediction and characterization of genetic variants in Familial Hypercholesterolemia and Hyperlipidemias
(2024-01-12)
El objetivo de mi tesis se centra en el desarrollo de técnicas in silico e in vitro para la predicción y caracterización de variantes causantes de hipercolesterolemia familiar e hiperlipemias. El uso de modelos y software ...