Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling

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Date
2016
Author
Abiega Etxabe, Oihane
Beccari Galeano, Marlene Soledad
Diaz-Aparicio, Irune
Nadjar, Agnes
Layé, Sophie
Leyrolle, Quentin
Gómez-Nicola, Diego
Domercq García, María ORCID
Pérez-Samartín, Alberto
Sánchez-Zafra, Víctor
Paris Guerrero, Ignacio
Valero Gómez-Lobo, Jorge
Savage, Julie C.
Hui, Chin-Wai
Tremblay, Marie-Ève
Deudero, Juan J. P.
Brewster, Amy L.
Anderson, Anne E.
Zaldumbide Dueñas, Laura
Galbarriatu, Lara
Marinas, Ainhoa
Vivanco Ruiz, María del Mar
Matute Almau, Carlos José
Maletic-Savatic, Mirjana
Encinas Pérez, Juan Manuel
Sierra Saavedra, Amanda
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PLOS Biology 14(5) : (2016) // e1002466
URI
http://hdl.handle.net/10810/19619
Abstract
Phagocytosis by microglia is tightly coupled to apoptosis, swiftly removing apoptotic cells and actively maintaining tissue homeostasis, but the neuronal hyperactivity associated with epilepsy disrupts the ATP gradients that drive phagocytosis, leading to the accumulation of apoptotic cells and inflammation.
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